Web of Science:
Unlocking Synergistic Potential: Agomelatine Enhances the Chemotherapeutic Effect of Paclitaxel in Breast Cancer Cell Through MT1 Melatonin Receptors and ER-alpha Axis

dc.contributor.authorDincer, B.
dc.contributor.authorYildiztekin, G.
dc.contributor.authorCinar, I.
dc.date.accessioned2023-10-18T05:41:38Z
dc.date.available2023-10-18T05:41:38Z
dc.date.issued2023.01.01
dc.description.abstractThis study investigates the potential of agomelatine (AGO), a synthetic melatoninergic drug, in combination with paclitaxel (PTX) for the treatment of breast cancer. The effects of AGO, PTX and melatonin (MTN) on breast cancer cell viability were investigated, focusing on the role of MT1 receptors. Cell viability and gene expression were analyzed in MCF-7 and MDA-MB-231 breast cancer cell experiments. The results show that AGO has cytotoxic effects on breast cancer cells similar to MTN. Combining AGO and MTN with PTX showed synergistic effects in MCF-7 cells. The study also reveals differences in the molecular mechanisms of breast cancer between estrogen-positive MCF-7 cells and estrogen-negative MDA-MB-231 cells. Combination with AGO and PTX affects apoptosis-associated proteins in both cell types. The findings suggest that AGO, combined with PTX, may be a promising adjuvant therapy for breast cancer and highlight the importance of MTN receptors in its mechanism of action.
dc.identifier.doi10.1002/cbdv.202301093
dc.identifier.eissn1612-1880
dc.identifier.endpage
dc.identifier.issn1612-1872
dc.identifier.issue
dc.identifier.pubmed37690997
dc.identifier.startpage
dc.identifier.urihttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=dspace_ku&SrcAuth=WosAPI&KeyUT=WOS:001074652200001&DestLinkType=FullRecord&DestApp=WOS
dc.identifier.urihttps://hdl.handle.net/20.500.12597/17792
dc.identifier.volume
dc.identifier.wos001074652200001
dc.language.isoen
dc.relation.ispartofCHEMISTRY & BIODIVERSITY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantitumor agents
dc.subjectcancer
dc.subjectgene expression
dc.subjectmedicinal chemistry
dc.titleUnlocking Synergistic Potential: Agomelatine Enhances the Chemotherapeutic Effect of Paclitaxel in Breast Cancer Cell Through MT1 Melatonin Receptors and ER-alpha Axis
dc.typeArticle
dspace.entity.typeWos

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