WoS İndeksli Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12597/3196

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  • Web of Science
    Sustainable foam concrete development: Enhancing durability and performance through pine cone powder and fly ash incorporation in alkali-activated geopolymers
    (2024.01.01) Bayraktar, OY; Özel, HB; Benli, A; Yilmazoglu, MU; Türkel, IH; Dal, BB; Sevik, H; Kaplan, G
  • Web of Science
    Palynological Study of Some Astragalus L. Sections Distributed in Türkiye
    (2024.01.01) Bilgi, H.; Çeter, T.; Bani, B.; Karabicak, S.; Biyiklioglu, O.; Özkutlu, I.; Elfogohi, L.
    In this study, the morphological properties of pollen of 14 species from 9 different sections of the genus Astragalus L. (Fabaceae) distributed in T & uuml;rkiye were examined, identified, and compared under light microscope (LM) and scanning electron microscope (SEM). Pollen grains of the studied taxa are radially symmetrical and isopolar. Pollen shapes were determined as prolate, subprolate, spheroidal, and prolate-spheroidal. The polar axis lengths of the pollen grains were determined to be between 24.5 and 34.4 mu m, and the equatorial axis lengths were determined to be between 22.4 and 27.5 mu m. The aperture type of pollen grains is mainly trizonacolporate, rarely trisyncolporate. Colpus are thin and long with acute ends. The shapes of the pores were determined as oblate, suboblate, or oblate-spheroidal. Colpus lengths were found to be between 18.2 and 28.8 mu m, and widths were found to be between 2.7 and 7.1 mu m. In the studied species, four types of ornamentation were determined according to the differences in the polar region and equatorial region. Type 1: perforate in polar and equatorial regions; Type 2: perforate in polar region, microreticulate in equatorial region; Type 3: microreticulate in polar and equatorial regions; Type 4: psilate-perforate in polar region, microreticulate in equatorial region. Principal component analysis (PCA) and unweighted pair group method using arithmetic average (UPGMA) analyses showed that morphological characters of pollen grains were effective in distinguishing species but could not contribute significantly to a distinction according to sections. Pollen size, colpus characteristics, and ornamentation were determined to be important characteristics that distinguish the studied taxa. This study contributes to Astragalus taxonomy and different sub-branches of palynology.
  • Web of Science
    A portable biosensor for simultaneous diagnosis of TNF-α and IL-1β in saliva biomarkers using twin electronic devices
    (2024.01.01) Monajjemi, M.; Mollaamin, F.; Dehghandar, M.; Shahriari, S.; Latifi, P.; Mohammadi, S.
    For several types of diseases, such as meningitis or oral cancers, the simultaneous diagnosis and measurement of the tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) immune-modulating biomarkers, with respect to both quality and quantity, are important. For example, although meningitis is generally caused by bacteria or viruses, the differences between viral and bacterial structures can be problematic for medical doctors to distinguish, as laboratory data assay techniques for the two are often similar and can overlap; moreover, in such cases, distinguishing between virial and bacterial structures is especially problematic following the use of antibiotics prior to cerebrospinal fluid testing. In this work, we simultaneously evaluated the precision of both TNF-alpha and IL-1 beta for the diagnosis of disease. In this research area, twin electrochemical biosensors have been designed as strong tools for the wide-spectrum assessment of biomarkers, thereby aiding in the screening, diagnosis, and monitoring of pathologies and treatment performance. In this research, we present a sensor platform model that can enable one to detect biomarkers quickly; specifically, this platform can be used to detect TNF-alpha and IL-1 beta in saliva. A two-peptide recognition element was created and designed using the phage display technique. This element selectively binds TNF-alpha and IL-1 beta to an electronics-based metal-oxide-semiconductor field-effect transistor/electrolyte-gated transistor (MOSFET/GT) bio-detector device and label-free biosensor, allowing for the rapid, simultaneous detection of both biomarkers. These bio-affinity recognition methods have been successfully implemented to realize the experimental twin-model sensor, based on electrolyte-gated transistor (EGT) and semiconductor field-effect transistor (ZnO-SFET) biosensors, to test for these two disease biomarkers, both individually and simultaneously, with high performance. In summary, we developed a sensor platform that can be used for rapid oral cancer signature analysis of biomarkers in multiple bio-fluids of saliva. This system works by arraying metal-oxide-semiconductor field-effect transistors (MOSFETs), with each targeting a biorecognition element (BRE) specific to one of these two important biomarkers. This system can also be extended upon to aid in a wide variety of cancer research applications.
  • Web of Science
    Effects of rainwater on the carrageenan yield and quality and dry yield biomass of eucheumatoid seaweed Kappaphycus alvarezii
    (2025.01.01) Tahiluddin, A.B.; Robles, R.J.F.; Eldani-Tahiluddin, M.H.S.
    Kappaphycus alvarezii, a commercially valuable eucheumatoid seaweed, is widely cultivated in equatorial regions for its kappa-carrageenan. A common post-harvest practice among local farmers involves drying the seaweed using the hanging method, often with exposure to rain. This study investigates the effects of rainwater exposure on the carrageenan yield and quality, as well as the dry yield biomass, of K. alvarezii. Four rainwater soaking times (0, 30, 60, and 90 min) were applied to both fresh and dried forms of K. alvarezii. The samples were then dried or re-dried, and their carrageenan properties were analyzed. Results indicate that rainwater significantly reduces dry yield biomass in both fresh and dried forms, while substantially improving carrageenan yield. In its fresh form, exposure to rainwater notably increased gel strength after 90 min of soak. However, when dried seaweed was soaked and re-dried, gel strength was reduced. Rainwater generally had no effect on viscosity or syneresis index. Gelling temperature was significantly affected by rainwater exposure in fresh seaweed but not in dried samples. Melting temperature in fresh forms was unaffected, but rainwater exposure reduced it in dried seaweed after 90 min of soak. Moisture content was significantly reduced by rainwater in both fresh and dried forms. This research highlights the potential impacts of rainwater on the post-harvest processing of Kappaphycus.
  • Web of Science
    Sustainable aviation fuel supplier evaluation for airlines through LOPCOW and MARCOS approaches with interval-valued fuzzy neutrosophic information
    (2025.01.01) Ecer, F.; Tanriverdi, G.; Yasar, M.; Görçün, Ö.F.
    In line with the 2050 net zero emission target, sustainable aviation fuel (SAF) is recognized as one of the most effective decarbonization solutions for the aviation industry, which has been identified among the critical areas for mitigating climate change. However, although sustainability issues and decarbonization have attracted scholars' attention in various terms for the airline industry, we identified some significant theoretical and managerial gaps as follows: (i) the number of studies evaluating sustainable suppliers by airlines via multicriteria decision-making (MCDM) approaches are very few, (ii) the extant literature has no paper addressing airlines' SAF supplier selection process, and (iii) no widely established criteria set in the literature to evaluate the SAF suppliers for airlines. We propose a novel model for the decision-making process of airlines' sustainable SAF supplier selection, including 39 criteria from 5 aspects considering the triple bottom of sustainability. The proposed model involves the combination of the logarithmic percentage change-driven objective weighting (LOPCOW) and measurement alternatives and ranking according to the compromise solution (MARCOS) approaches' extended forms based on the interval-valued fuzzy neutrosophic numbers (IVFNN). A comprehensive sensitivity and comparison control is further exploited to display the developed framework's robustness and practicality. Our results suggest that airlines prioritize the green initiatives of SAF suppliers over the economic aspect in the process of sustainable SAF supplier selection. We provide some managerial and policy insights for practitioners and policy-makers in the airline industry and some directions for further research.
  • Web of Science
    Efficacy of Low-Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats
    (2024.01.01) Yilmaz, G.B.; Saracoglu, K.T.; Aykin, U.; Akca, M.; Demirtas, C.; Saracoglu, A.; Yildirim, M.
    Refractory status epilepticus (RSE) is a condition with serious mortality and morbidity rate, resistant to benzodiazepine and second-line antiepileptic drugs. This study aimed to electrophysiologically investigate the combination of NMDA receptor antagonist ketamine and GABAergic agent propofol in an RSE model induced by lithium-pilocarpine in male Sprague-Dawley rats. Seventy-two male Sprague-Dawley rats were divided into nine groups. The RSE model was induced by subcutaneous injection of lithium-CI (5 mEq/kg) and intraperitoneal injection of pilocarpine-HCl (320 mg/kg), after implanting tripolar EEG electrode. Ketamine (30, 60, and 90 mg/kg), propofol (20, 40, and 80 mg/kg), and combinations of both drugs (15 + 20 and 30 + 40 mg/kg) were administered intraperitoneally to animals with RSE. Video-EEG recordings were taken after inducing model and 48 h later. The efficacy of drugs was statistically evaluated based on spike frequencies (spikes/min) and amplitudes (mV). Compared to RSE group, it was determined that 30 and 60 mg/kg doses of ketamine provided effective seizure control and prevented mortality (p < 0.001), while the 90 mg/kg showed toxic effects in all animals and caused mortality. The 80 mg/kg dose of propofol provided seizure control and reduced the mortality rate to 16.7% (p < 0.001), whereas the 20 mg/kg resulted in a 100% mortality rate. The low-dose ketamine+propofol (15 + 20 mg/kg) combination provided early onset seizure control and were as effective as 80 mg/kg propofol (p < 0.05). The study concluded that in the experimental RSE model, seizure control could be achieved with low-dose combination of ketamine and propofol without the need for high doses as in monotherapy, thus preventing dose-related adverse effects.
  • Web of Science
    Exposure to a 0.9-GHz electromagnetic field on postnatal days 21-45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study
    (2025.01.01) Keles, A.I.; Kaya, H.; Keles, G.; Erol, H.S.; Mercantepe, T.; Odaci, E.
    The aim of this study was to examine the relationship between the renin-angiotensin system (RAS) and histological and biochemical changes occurring in the kidney tissue of male rats exposed to a 0.9 GHz electromagnetic field (EMF). Twelve male rats aged 21 days were randomly assigned to control (C-Gr) and EMF (EMF-Gr) groups. No procedure was performed on C-Gr, while the EMF-Gr rats were exposed to a 0.9 GHz EMF on postnatal days 21-45 (one hour a day for 25 days). Tissues were removed at the end of the experiment and evaluated using biochemical, and histopathological methods. Increased kidney tissue volume and weight and total body weight were determined in the group exposed to EMF. Lipid peroxidation, glutathione, catalase, and superoxide dismutase also increased in the kidney tissue of the EMF-Gr rats. Histopathological evaluation revealed cortical/medullary bleeding/obstruction and widespread fibrosis, dilatation, vacuolization, and degeneration in distal and proximal tubules, decreased and atypical parietal cells, and degeneration in epithelial cells. Additionally, dilated and degenerated glomeruli in the Malpighian body, Bowman's membrane degeneration and degeneration in the vascular pole, podocyte, pedicel and mesangial cells were also observed. As a result of exposure to EMF, oxidative stress, tissue volume and weight increased, and histopathological changes caused the formation of a pathway that triggers RAS in kidney tissues. In conclusion, long-term exposure to 0.9 GHz EMF can activate the renin-angiotensin system in the rat kidney, and we think that such activation may be associated with structural, histopathological, and biochemical changes occurring in renal tissue.
  • Web of Science
    The Role of Hearing Aids in Improving Dual-Task Gait Performance in Older Adults With Presbycusis: A Cognitive and Motor Analysis
    (2024.01.01) Soylemez, E.; Soylemez, T.G.; Apaydin, A.S.; Apaydin, Z.K.; Yasar, M.
    Background: Cognitive decline is a common challenge faced by older individuals with presbycusis; their performance on dual-task (DT) activities is generally lower compared to those without hearing loss. However, the influence of hearing aids on nonauditory cognitive decline in this population remains unclear. This study aims to investigate the effect of hearing aids on nonauditory DT performance in older adults with presbycusis. Material and Methods: This study included older people with presbycusis who used hearing aids (P&HA group), those with presbycusis who did not use hearing aids (PoHA group), and a control group of healthy adults. Forward and backward digit span tests and timed up and go test (TUG) were administered to all individuals. TUG and motor and cognitive (forward and backward digit span) tasks were applied simultaneously to evaluate the participants' DT performance. Results: The study comprised 60 individuals with presbycusis (19 females, 41 males; mean age: 73.23 +/- 6.49 years) and 30 healthy adults (15 females, 15 males; mean age: 35.93 +/- 8.57 years). Healthy adults performed better than the P&HA and PoHA groups in all the administered tests (p < 0.05). There was a moderate negative relationship between the severity of hearing loss and the forward and backward digit span test performances (p < 0.05). The P&HA group performed better than the PoHA group on the DT cognitive forward and backward digit span tests. Conclusion: The use of hearing aids and their proper fitting are important not only for improving communication skills and reducing listening effort but also for supporting nonauditory cognitive functions, minimizing the risk of falls during DT activities, and enhancing the overall quality of life.
  • Web of Science
    Polymeric Adsorbent for the Effective Removal of Toxic Dyes from Aqueous Solutions: Equilibrium, Kinetic, and Thermodynamic Modeling
    (2024.01.01) Oter, C.; Gokkus, K.; Gur, M.; Butun, V.
    This study investigates the adsorption behavior of anionic (Congo red, Eosin yellow) and cationic (Malachite green) dyes on synthesized TD polymer particles, highlighting the material's potential as an effective adsorbent for industrial wastewater treatment. Key operational parameters, including initial solution's pH, contact time, initial dye concentration, and temperature, were systematically evaluated to determine their influence on adsorption efficiency. The experimental data demonstrated that the Langmuir isotherm provided the best fit for all three dyes, indicating monolayer adsorption with maximum adsorption capacities of 153.8 mg/g for Malachite green, 49.36 mg/g for Congo red, and 227.9 mg/g for Eosin yellow. Kinetic analysis revealed that the adsorption of Malachite green and Congo red followed pseudo-second-order kinetics, while Eosin yellow adsorption was better described by the intra-particle diffusion model. Thermodynamic assessments, including Gibbs free energy (Delta G degrees), enthalpy (Delta H degrees), and entropy (Delta S degrees), confirmed the spontaneous and endothermic nature of the adsorption processes for Malachite green and Eosin yellow, contrasting with the exothermic behavior observed for Congo red. These findings underscore the versatility and effectiveness of TD polymer particles in removing both anionic and cationic dyes from aqueous solutions. Further research could explore material optimization and real-world applications to broaden their utility in sustainable water treatment strategies.
  • Web of Science
    A broad-spectrum biological activities of Heracleum humile extracts: A first report of the antiviral, anti-cancer and chemical properties
    (2024.01.01) Ocal, M.; Yelken, S.D.; Altunoglu, Y.C.; Baloglu, M.C.; Soomro, S.I.; Zengin, G.; Angeloni, S.; Mustafa, A.M.; Caprioli, G.; Paksoy, M.Y.
    The current work focused on researching the bioactive potential of ethyl acetate (EA), methanol (MeOH), and water extract of H. humile plant, specifically ethyl acetate, methanol extracts were acquired with maceration method, and water extract was obtained by the infusion method. The highest total phenolic ingredient was determined in the water extract, while the highest total flavonoid ingredient was found in the MeOH extract. The water extract displayed the most potent antioxidant activity in the assays used. The ethyl acetate extract showed the highest enzyme inhibition activity in Butyrylcholinesterase inhibition (BChE) and amylase assay. Antibacterial efficiency was analyzed using microdilution analysis. The minimum inhibitory concentration (MIC) amounts ranged from 125 to 500 mu g/mL except for water extract. The antiviral potential of the extracts was assessed against Bovine herpes virus 1 (BoHV-1) (Cooper strain). Methanol extract showed more potent antiviral effect. Selectivity indices were calculated for ethyl acetate and methanol extract as 3.32 and 13.39, respectively. All extracts displayed Deoxyribonucleic Acid (DNA) protection activity at approximately 25%-35%. For cell viability evaluation, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) test was performed against triple-negative human breast adenocarcinoma cells (MDA-MB-231) and Michigan Cancer Foundation-7 (MCF-7) cells. The most effective results were found in ethyl acetate extract at 48h. The 50% inhibitor concentrations (IC50) were determined for MDA-MB-231 and MCF-7 as 116.7 mu g/mL and 247.9 mu g/mL, respectively. Based on the bioactive compound content results, extracts of H. humile include valuable compounds that possess significant biological properties. In conclusion, these extracts could offer promising novel plant-derived therapeutics.
  • Web of Science
    THE MEDIATOR ROLE OF TECHNOLOGY USE LEVEL IN THE EFFECT OF SOCIAL MEDIA ON ONLINE PURCHASE INTENTION
    (2024.01.01) Özbey, K.Y.; Çavdar, E.
    In the literature, studies indicating that social media use and technology usage level positively affect online purchasing behaviour draw attention. Considering that social media use may affect the frequency and level of technology use, the mediating role of the level of technology use in the effect of social media use on online purchasing behaviour was investigated. For this purpose, analyses were conducted using Process Macro 4.2 (Model 4). The survey data applied online were evaluated, and the data of 409 participants were included in the analysis. As a result of the analyses, it was determined that social media use significantly affects online purchasing behaviour. It was also found that the level of technology usage significantly affected online purchasing behaviour. As a result of the mediation test, it was found that the level of technology use has a strong mediating effect on the effect of social media use on online purchasing behaviour.
  • Web of Science
    Evaluation of the Antimicrobial Effects of Olive Mill Wastewater Extract Against Food Spoiling/Poisoning, Fish-Pathogenic and Non-Pathogenic Microorganisms
    (2024.01.01) Yilmaz, D.K.; Kesbic, F.I.; Celik, E.S.; Odabasi, D.A.; Yilmaz, S.; Abdel-Latif, H.M.R.
    Although antibiotics are the main therapy for bacterial infections, the reports showed that the overuse (or misuse) of antibiotics will results in several problems such as the development of antibiotic-resistant strains, persistence of drug residues, and numerous environmental concerns. Therefore, finding antibiotic alternatives is considered of vital importance. Investigation of the antimicrobial properties of several plant substances and extracts is of great value to replace antibiotics. With this objective, this study aimed to evaluate the antimicrobial activities of an ethanolic extract prepared from olive mill wastewater (OMWW), which is a by-product of olive oil production with considerable environmental burden, against 38 bacterial strains, including fish-associated pathogens, non-pathogenic isolates, collection strains, and one yeast strain, Candida albicans. Disk diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal/fungicidal concentration (MBC/MFC) tests were used to determine the antimicrobial activity of the OMWWE. According to the results, OMWWE provoked strong inhibitory effects against Shewanella baltica strain SY-S145. It also showed a moderate inhibitory effect on Plesiomonas shigelloides strain SY-PS16 and Vibrio anguillarum strain SY-L24. The MIC and MBC of OMWWE on Shewanella baltica SY-S145, Vibrio gigantis strain C24, and V. anguillarum strain SY-L24 were 500 mu g/mL. The MIC and MBC on V. parahaemolyticus ATCC 17802 were 1000 mu g/mL, whereas the values for Aeromonas salmonicida ATCC 33658 were 500 mu g/mL and 1000 mu g/mL, respectively. To put it briefly, the OMWW extract showed high antimicrobial activity and can act as an environmentally friendly additive for the control and prevention of diseases caused by A. veronii, A. hydrophila, P. shigelloides, S. baltica, V. anguillarum, and V. parahaemolyticus. Its active agents also prevented infections of both fish-associated pathogens and food spoiling bacteria, which means it can not only help in the disease control mechanism but also in improving the safety of food by reduction of the microbial contamination.
  • Web of Science
    Classification of Ionospheric Disturbances Using Long Short Term Memory Algorithm
    (2024.01.01) Gul, S.E.; Karatay, S.; Arikan, F.
    In this study, disturbances in the ionosphere during periods of geomagnetic activity and seismic activity are classified with the Long Short Term Memory algorithm, one of the Deep Learning algorithms. It is observed that the classification Accuracy is at least 84% in the classification of five earthquake and five disturbance days based on the Total Electron Content data input.
  • Web of Science
    Assessment of tibialis anterior tendon insertion variations in relation to hallux valgus utilizing magnetic resonance imaging
    (2024.01.01) Ugur, F.; Albayrak, M.; Akar, B.; Reis, B.
    BackgroundHallux valgus is a deformity characterized by lateral deviation of the big toe and medial deviation of the first metatarsal, causing difficulty in walking and requiring various treatments. Despite its multifactorial etiology, the role of the tibialis anterior tendon in hallux valgus and its variations in the morphology of tibialis anterior tendon distal insertion sites have not been fully explored. This study aimed to evaluate the effect of such variations on hallux valgus using magnetic resonance imaging.MethodsThis was a retrospective study and included 115 individuals aged 18 years and older who underwent foot radiographs and MRI. The participants were divided into a hallux valgus group of 53 patients and a control group of 62 people based on radiographic measurements. Tibialis anterior tendon distal attachment was classified into five types according to the attachment morphology. Statistical analyses were performed to evaluate the relationship between the tibialis anterior tendon types and hallux valgus severity.ResultsAmong the participants, patients who underwent foot radiography and MRI due to any medical indication 70.4% were female, with a mean age of 43.83 +/- 15.25 years. In terms of tibialis anterior tendon distal attachment, the most common type was Type 5 (40.9%), followed by Type 2 (34.8%). Type 4 was not observed in any case. In all participants, the mean hallux valgus angle was 20.63 +/- 8.42o, and the mean intermetatarsal angle was 9.69 +/- 2.68o. Tibialis anterior tendon distal attachment Type 5 was significantly associated with an increased hallux valgus angle but not with the intermetatarsal angle. We found a significant relationship between the diameter of the tibialis anterior tendon and hallux valgus angle.ConclusionsThis study revealed a significant association between hallux valgus and Type 5 tibialis anterior tendon distal attachment, suggesting that tibialis anterior tendon morphology influences hallux valgus severity. The findings underscore the importance of considering variations in tibialis anterior tendon distal attachment sites in the etiopathogenesis and treatment planning of hallux valgus.
  • Web of Science
    Hair and Blood Trace Elements (Cadmium, Zinc, Chrome, Lead, Iron and Copper) Biomonitoring in the Athletic Horse: The Potential Role of Haematological Parameters as Biomarkers
    (2024.01.01) Aragona, F.; Giannetto, C.; Piccione, G.; Licata, P.; Deniz,Ö.; Fazio, F.
    The aim of the present study was the evaluation of the bioaccumulation of cadmium (Cd), Zinc (Zn), Chrome (Cr), Lead (Pb), Iron (Fe) and Copper (Cu), in the blood, serum, tail and mane of horses from the industrialized area of Milazzo (Messina, Sicily), to understand the relationships between haematological parameters: Red Blood Cells (RBCs), White Blood Cells (WBCs), Haemoglobin (Hb), Haematocrit (Hct), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), Platelets (PLTs) and the concentrations of trace elements. Blood and hair samples from 20 healthy Italian Saddle horses and water, hay and concentrates samples were obtained to determine the haemogram and mineral concentration using a Thermo Scientific iCAP-Q ICP-MS spectrometer. Descriptive analysis showed a higher concentration of Zn, Cr, Pb, Fe, and Cu in the blood and a higher concentration of Cd in the tail than other substrates. A positive correlation was found for Cr (p < 0.0001) and Zn (p < 0.01) between blood and serum substrates, for Zn (p < 0.001) between mane and tail and for Pb (p < 0.01) between blood and mane, while a negative correlation was observed for Cr (p < 0.01) between blood and tail. Results showed a close relationship between the bioaccumulation of certain trace elements in biological substrates and haematological parameters, which represent useful biomarkers suggesting further studies, given the role of haematological parameters in athletic horses.
  • Web of Science
    The Effects of a Smartphone App-Supported Nursing Care Program on the Disease Self-Management of Hypertensive Patients: A Randomized Controlled Study
    (2024.01.01) Arabaci, Z.; Toraman, A.U.
    AimHypertension is one of the most common chronic diseases worldwide. Therefore, it is essential to improve patients' adherence to treatment in order to control their blood pressure. The present study aims to examine the effect of a smartphone application-supported nursing care program provided by a nurse on medication adherence and achievement of normal systolic and diastolic blood pressure levels among patients diagnosed with primary hypertension and registered at the Family Health Center within the context of patients' self-management behaviors.MethodsA randomized controlled experimental study design. CONSORT flow chart was used in the study. The study sample consisted of 41 hypertensive patients in the intervention group and 41 hypertensive patients in the control group. The intervention group was supported with a smartphone application named "HiperDostum" based on the health belief model, whereas the control group continued to receive standard healthcare services provided by the Family Health Center, to which they were affiliated. Data were collected using the "Patient Information Form," "Blood Pressure Monitoring Form," and the "Medication Adherence Self-Efficacy Scale-Short Form."ResultsIt was observed that the intervention group participants had higher medication adherence self-efficacy scale scores when compared to the control group participants. Comparing the blood pressure values by group, time, and group*time interaction, it was determined that there were statistically significant differences in systolic blood pressure values by time and group*time interaction.ConclusionConsidering the widespread use of smartphones and smartphone application-supported nursing care can be successfully used to enhance self-management and improve treatment adherence among hypertensive patients in primary healthcare institutions.Trial RegistrationRegistration number: NCT0532140;Name of trial registryThe Effect of Smart Phone Application Supported Nursing Care Program on the Self-Management of Hypertensive Patients
  • Web of Science
    Effect of VDR and TLR2 gene variants on the clinical course of patients with COVID-19 disease
    (2024.01.01) Kuruca, N.; Atilla, A.; Kaya, M.T.; Gokmen, S.; Nursal, A.F.; Kilic, O.; Kuruoglu, T.; Temocin, F.; Guvenc, T.; Yigit, S.; Guvenc, D.
    The coronavirus disease 2019 (COVID-19) pandemic, which has caused a major global health crisis, primarily targets the upper and lower respiratory tract. But infected individuals may experience different clinical symptoms, ranging from asymptomatic to critical. The vitamin D receptor (VDR) and Toll-like receptor 2 (TLR2) polymorphisms play a role in the immune response. This study aimed to evaluate the effect of VDR Bsml (rs1544410) and TLR2 23bp indel variants on the clinical status of Turkish patients with COVID-19 disease. A total of 312 people, including 106 intensive care unit (ICU) patients, 103 symptomatic hospitalized patients, and 103 healthy controls, were included in the study. The VDR BsmI and TLR2 23bp indel were genotyped using polymerase chain reaction and/or restriction fragment length fraction methods. The VDR BsmI b/b genotype and b allele were higher in symptomatic patients compared to the healthy control group (p = 0.035). The VDR BsmI B/B and B/b genotype distribution did not differ between ICU patients and both symptomatic patients and controls (p > 0.05). We found that B/B:B/b+b/b and B/B+B/b:b/b were significantly different in symptomatic patients compared to controls (p = 0.033 and p = 0.041, respectively). The VDR BsmI b/b genotype distribution was found to be lower in deceased patients than in living patients (p = 0.023). There was no significant difference between the groups in terms of TLR2 23bp indel genotype and allele distribution (p > 0.05). Our study results suggest that the VDR BsmI b allele may have a role in COVID-19 patients with symptomatic findings. These data need to be repeated in different ethnic and larger sample groups.
  • Web of Science
    Effect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout (Oncorhynchus mykiss)
    (2024.01.01) Uney, K.; Corum, D.D.; Marin, P.; Coskun, D.; Terzi, E.; Badillo, E.; Corum, O.
    Danofloxacin is a fluoroquinolone antibiotic approved for use in fish. It can be used for bacterial infections in fish of all body sizes. However, physiological differences in fish depending on size may change the pharmacokinetics of danofloxacin and therefore its therapeutic efficacy. In this study, the change in the pharmacokinetics of danofloxacin in rainbow trout of various body sizes was revealed for the first time. The objective of this investigation was to compare the plasma and tissue pharmacokinetics of danofloxacin in rainbow trout of different body sizes. The study was conducted at 14 +/- 0.5 degrees C in fish of small, medium, and large body size and danofloxacin was administered orally at a dose of 10 mg/kg. Concentrations of this antimicrobial in tissues and plasma were quantified by high performance liquid chromatography with ultraviolet detector. The plasma elimination half-life (t1/2 lambda z), volume of distribution (Vdarea/F), total clearance (CL/F), peak concentration (Cmax), and area under the plasma concentration-time curve (AUC0-last) were 27.42 h, 4.65 L/kg, 0.12 L/h/kg, 2.53 mu g/mL, and 82.46 h center dot mu g/mL, respectively. Plasma t1/2 lambda z, AUC0-last and Cmax increased concomitantly with trout growth, whereas CL/F and Vdarea/F decreased. Concentrations in liver, kidney, and muscle tissues were higher than in plasma. Cmax and AUC0-last were significantly higher in large sizes compared to small and medium sizes in all tissues. The scaling factor in small, medium, and large fish was 1.0 for bacteria with MIC thresholds of 0.57, 0.79, and 1.01 mu g/mL, respectively. These results show that therapeutic efficacy increases with body size. However, since increases in danofloxacin concentration in tissues of large fish may affect withdrawal time, attention should be paid to the risk of tissue residue.
  • Web of Science
    Real or Artificial Stability of Ions and Deuterated Variants Based on Ab Initio Calculation and Rotational Spectrum
    (2024.01.01) Monajjemi, M.; Mollaamin, F.
    Protonated methane, , has unusual vibrational and rotational behavior because its three non-equivalent equilibrium structures have nearly identical energies and its five protons scramble freely. Thehighly f lexible , molecular ion has been shown by ab initio calculations to have 120 symmetrically equiv-alent minima of Cs symmetry in its ground electronic state. Complete proton rearrangement, making all min-ima accessible to each other, is possible as a result of two large-amplitude internal motions: an internal rota-tion about the C3 axis with an ab initio barrier of 30 cm-1 and an internal f lip motion with an ab initio barrierof 300 cm-1 that exchanges protons between the H2 and groups. We calculate the structure of the J =21 and 1 0 rotational transitions of , and also other variants containing . Althoughmany theoretical papers have been published on the quantum mechanics of these systems, a better under-standing requires spectral and conformational analysis. Post Hartree-Fock, M & oslash;ller-Plesset and DFT calcu-lation with the correlation consistent polarized valence double and triple zeta basis sets have done for thezero-point energies of . The present results indicates the mode 8, 12, and 10 agree with qualitativeof , which is highly f luxional and has a complex spectrum while the C-X bonds which are broken andreformed all the time. The spectrum of mode 12 is highly complex with huge red-and some blue shifts. In par-ticular, they can be attributed to the rapid coupling of the original CH-stretching normal mode to motionsmore closely related to isomerization, i.e., bending or rocking. There has thus been a long debate whether has a structure at all or not and is it real rotational motions or artificial. In addition, we include the con-tribution to the torsional barrier from the zero point energies of the other (high-frequency) vibrations, theeffect of centrifugal distortion, and the effect of second-order rotation-vibration interactions