Web of Science:
The potential protective effects of melatonin and omega-3 on the male rat optic nerve exposed to 900?MHz electromagnetic radiation during the prenatal period

dc.contributor.authorTuefekci, K.K.
dc.contributor.authorKaplan, A.A.
dc.contributor.authorKaya, A.
dc.contributor.authorAlrafiah, A.
dc.contributor.authorAltun, G.
dc.contributor.authorAktas, A.
dc.contributor.authorKaplan, S.
dc.date.accessioned2023-10-09T08:27:03Z
dc.date.available2023-10-09T08:27:03Z
dc.date.issued2023.01.01
dc.description.abstractBackground: Due to children and adolescents' widespread use of electronic devices, researchers have focused on pre-and early postnatal electromagnetic field (EMF) exposure. However, little is known about the effects of EMF exposure on the optic nerve. The aim of study was to investigate the changes occurring in the optic nerve and the protective effects of melatonin (mel) and omega 3 (?-3) in rats.Methods: Thirty-five pregnant rats were divided into seven groups, Cont, Sham, EMF, EMF + melatonin (EMF + Mel), EMF + ?3, Mel, and ?3. The EMF groups were exposed to 900 megahertz (MHz) EMF daily for two hours during pregnancy. After the experiment, the right optic nerve of each offspring rat was removed and fixed in glutaraldehyde. Thin and semi-thin sections were taken for electron microscopic and stereological analyses. Myelinated axon numbers, myelin sheath thicknesses, and axonal areas were estimated using stereological methods.Results: The groups had no significant differences regarding mean numbers of axons, mean axonal areas, or mean myelin sheath thicknesses (p > 0.05). Histological observations revealed impaired lamellae in the myelin sheath of most axons, and vacuolization was frequently observed between the myelin sheath and axon in the EMF-exposed group. The Mel and ?-3-treated EMF groups exhibited well-preserved myelinated nerve fibers and intact astrocytes and oligodendrocytes.Conclusions: At the ultrastructural level, Mel and ?3 exhibits a neuroprotective effect on the optic nerve exposed to prenatal EMF. The protective effects of these antioxidants on oligodendrocytes, which play an essential role in myelin formation in the central nervous system, now require detailed investigation.
dc.identifier.doi10.1080/00207454.2023.2259078
dc.identifier.eissn1563-5279
dc.identifier.endpage
dc.identifier.issn0020-7454
dc.identifier.issue
dc.identifier.pubmed37712630
dc.identifier.startpage
dc.identifier.urihttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=dspace_ku&SrcAuth=WosAPI&KeyUT=WOS:001071071600001&DestLinkType=FullRecord&DestApp=WOS
dc.identifier.urihttps://hdl.handle.net/20.500.12597/17651
dc.identifier.volume
dc.identifier.wos001071071600001
dc.language.isoen
dc.relation.ispartofINTERNATIONAL JOURNAL OF NEUROSCIENCE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAxon
dc.subjectmelatonin
dc.subjectomega-3
dc.subjectnucleator
dc.subjectfractionator
dc.titleThe potential protective effects of melatonin and omega-3 on the male rat optic nerve exposed to 900?MHz electromagnetic radiation during the prenatal period
dc.typeArticle
dspace.entity.typeWos

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