Web of Science:
Protective Effect of Myricetin Against Experimentally Induced Torsion in Rats

dc.contributor.authorTatar, M.
dc.contributor.authorPolat, Z.
dc.contributor.authorÖner, J.
dc.contributor.authorÖner, H.
dc.date.accessioned2023-11-01T06:01:09Z
dc.date.available2023-11-01T06:01:09Z
dc.date.issued2023.01.01
dc.description.abstractTesticular torsion causes ischemia and free radical formation by obstructing vascular flow caused by complete or partial rotation of the testis. Myricetin is a plant-derived flavonoid with various biological effects, such as potent anti-oxidation and anti-inflammatory properties. The study aims to evaluate the protective effects of myricetin on the apoptosis of testicular germ cells after experimental testicular torsion. Twenty-four Wistar albino rats were divided into four groups; Control, Sham, Torsion group (720 deg torsion for 2 h), and Myricetin group (torsion model was created, and myricetin injection (1.5 mg/kg) was done during seven days). End of the experiment, testis tissues were removed and fixed in Bouin's solution. Crossman's triple stain was done to determine the histological changes. Also, 8-OHdG and Caspase-3 immunoreactivities were assessed, and TUNEL staining was done. According to the results, we found that 8-OHdG, Caspase-3 immunoreactivity, and TUNEL-positive cells increased, accompanied by several histopathological changes in the torsion group. In contrast, myricetin significantly attenuated testicular injury by reducing apoptosis and DNA damage. These findings suggest that myricetin protects testes against torsion-induced damage in rats, possibly by reducing oxidative stress and inhibiting apoptosis. Our study provides a theoretical basis for further research into maintaining male reproductive health.
dc.identifier.doi10.1134/S1062359023603221
dc.identifier.eissn1608-3059
dc.identifier.endpage
dc.identifier.issn1062-3590
dc.identifier.issue
dc.identifier.startpage
dc.identifier.urihttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=dspace_ku&SrcAuth=WosAPI&KeyUT=WOS:001083625500021&DestLinkType=FullRecord&DestApp=WOS
dc.identifier.urihttps://hdl.handle.net/20.500.12597/17833
dc.identifier.volume
dc.identifier.wos001083625500021
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecttorsion
dc.subjectmyricetin
dc.subject8-OHdG
dc.subjectcaspase-3
dc.subjectapoptosis
dc.titleProtective Effect of Myricetin Against Experimentally Induced Torsion in Rats
dc.typeArticle
dspace.entity.typeWos

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