The potential protective effects of curcumin on the diabetic ovary: Experimental and molecular approaches

Abstract

systemic diseases in animals and humans. This may also lead to reproductive problems among individuals of reproductive age. Detrimental effects such as apoptosis in ovarian granulosa cells, degradation of communication proteins, decreased oocyte quality, delayed meiotic maturation, and atrophy are among the increasing evidence that chronic hyperglycemia causes reproductive problems. Numerous studies have reported that the antidiabetic properties of the antioxidant curcumin may be due to its inhibition of oxidative stress, inflammation, and insulin resistance. There are also data indicating that curcumin reduces the risk of DM and its associated symptoms. This review discusses the protective or curative properties of curcumin in the treatment of DMrelated problems in the ovary and seeks to elucidate potential underlying mechanisms. While the use of introduced for the reduction of reproductive problems that may be caused by uncontrolled DM, more studies on this subject are needed.