Scopus: Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
dc.contributor.author | Uney K. | |
dc.contributor.author | Tras B. | |
dc.contributor.author | Corum O. | |
dc.contributor.author | Yildiz R. | |
dc.contributor.author | Maden M. | |
dc.date.accessioned | 2023-04-12T01:55:50Z | |
dc.date.available | 2023-04-12T01:55:50Z | |
dc.date.issued | 2019-02-15 | |
dc.description.abstract | This study investigated the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after single-dose intravenous (IV) administration (10 mg/kg) of PTX in six healthy cattle. The safety of PTX was evaluated by clinical observation and biochemical analysis. Plasma concentrations of PTX and M-I were simultaneously determined by reverse-phase high performance liquid chromatography. Pharmacokinetic parameters were calculated using non-compartmental methods. Salivation and discomfort were observed for 2 h following the drug administration. Serum direct bilirubin, total bilirubin, and phosphorus levels at 24 h following the drug administration were significantly different from the control values (0 h) (P < 0.05). Pharmacokinetic variables of PTX were characterized by a short terminal elimination half-life (1.05 ± 0.19 h), a large volume of distribution (6.30 ± 1.76 L/kg), and high total body clearance (5.31 ± 1.27 L/h/kg). The mean ratio between the area under the concentration-time curves of M-I and PTX was 1.34. These results indicate that single-dose administration of PTX at 10 mg/kg IV in cattle resulted in therapeutic concentrations similar to those observed in humans and horse. However, further studies are necessary to determine the safety and pharmacokinetics following repeated administrations of PTX. | |
dc.identifier.doi | 10.1007/s11250-018-1710-8 | |
dc.identifier.issn | 00494747 | |
dc.identifier.pubmed | 30219998 | |
dc.identifier.scopus | 2-s2.0-85053618278 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/5084 | |
dc.relation.ispartof | Tropical Animal Health and Production | |
dc.rights | false | |
dc.subject | Cattle | Intravenous | M-I metabolite | Pentoxifylline | Pharmacokinetics | |
dc.title | Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle | |
dc.type | Article | |
dspace.entity.type | Scopus | |
oaire.citation.issue | 2 | |
oaire.citation.volume | 51 | |
person.affiliation.name | Selçuk Üniversitesi | |
person.affiliation.name | Selçuk Üniversitesi | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Mehmet Akif Ersoy Üniversity | |
person.affiliation.name | Selçuk Üniversitesi | |
person.identifier.scopus-author-id | 8408064700 | |
person.identifier.scopus-author-id | 6701311436 | |
person.identifier.scopus-author-id | 55902904600 | |
person.identifier.scopus-author-id | 15756686000 | |
person.identifier.scopus-author-id | 7006290235 | |
relation.isPublicationOfScopus | e2a1399d-904f-4319-bc56-7ce363fb28f9 | |
relation.isPublicationOfScopus.latestForDiscovery | e2a1399d-904f-4319-bc56-7ce363fb28f9 |