Scopus:
Ameliorative effect of hesperidin on streptozotocin-diabetes mellitus-induced testicular DNA damage and sperm quality degradation in Sprague–Dawley rats

dc.contributor.authorAksu E.H.
dc.contributor.authorKandemir F.M.
dc.contributor.authorKüçükler S.
dc.date.accessioned2023-04-12T00:41:43Z
dc.date.available2023-04-12T00:41:43Z
dc.date.issued2021-10-01
dc.description.abstractThis study aimed to investigate the effect of hesperidin on reproductive damage caused by diabetes mellitus. A total of 24 adult male rats were divided into four groups: control group, hesperidin group, diabetes mellitus group, and diabetes mellitus + hesperidin group. The study was conducted for 4 weeks. At the end of the study, the rats were sacrificed and testicular oxidative stress markers (MDA, GSH, GSH-Px, SOD, and CAT), DNA damage in testes (8-OHdG), and routine sperm parameters were evaluated. According to the results of the study, most of the parameters were similar in the control and hesperidin groups but CAT activity in the hesperidin group was statistically higher than the control group. Also, diabetes mellitus (DM) significantly increased MDA levels and decreased enzymatic antioxidant (GSH-Px, SOD, CAT) activities and nonenzymatic (GSH) antioxidant levels. On the other hand, hesperidin supplementation significantly decreased oxidative stress and increased enzymatic antioxidant activities and nonenzymatic antioxidant levels due to the antioxidant effect. Also, DM increased DNA damage levels in testicular tissue and hesperidin supplementation significantly decreased DNA damage levels in testes of diabetic male rats. Besides, sperm motility significantly decreased while abnormal sperm rate and dead sperm rate were significantly increased in diabetic rats. Hesperidin supplementation significantly reduced these side effects in diabetic rats. In conclusion, hesperidin supplementation could be beneficial for decreasing the side effects on the male reproductive system caused by DM in rats. Practical applications: Diabetes is an important metabolic disease, affecting quality of life and fertility. Hesperidin has an antioxidant effect and has a potential protective effect on reproductive toxicity in diabetic male rats. Hesperidin decreased oxidative stress, and DNA damage in testis resulted from hyperglycemia and improved sperm quality in diabetic rats. The hesperidin supplementation could be a good strategy to protect male fertility in diabetic patients.
dc.identifier.doi10.1111/jfbc.13938
dc.identifier.issn01458884
dc.identifier.pubmed34532874
dc.identifier.scopus2-s2.0-85114920196
dc.identifier.urihttps://hdl.handle.net/20.500.12597/4342
dc.relation.ispartofJournal of Food Biochemistry
dc.rightstrue
dc.subjectdiabetes mellitus | DNA damage | hesperidin | sperm quality
dc.titleAmeliorative effect of hesperidin on streptozotocin-diabetes mellitus-induced testicular DNA damage and sperm quality degradation in Sprague–Dawley rats
dc.typeArticle
dspace.entity.typeScopus
oaire.citation.issue10
oaire.citation.volume45
person.affiliation.nameKastamonu University
person.affiliation.nameAtatürk Üniversitesi
person.affiliation.nameAtatürk Üniversitesi
person.identifier.orcid0000-0003-1591-684X
person.identifier.orcid0000-0002-8490-2479
person.identifier.orcid0000-0002-8222-5515
person.identifier.scopus-author-id23468769500
person.identifier.scopus-author-id27368037600
person.identifier.scopus-author-id57148379500
relation.isPublicationOfScopusd7934d27-e614-4bd1-9fc2-4c3754ab515c
relation.isPublicationOfScopus.latestForDiscoveryd7934d27-e614-4bd1-9fc2-4c3754ab515c

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