Scopus:
Immune responses to methanolic extract of black cumin (Nigella sativa) in rainbow trout (Oncorhynchus mykiss)

dc.contributor.authorCelik Altunoglu Y.
dc.contributor.authorBilen S.
dc.contributor.authorUlu F.
dc.contributor.authorBiswas G.
dc.date.accessioned2023-04-12T02:26:47Z
dc.date.available2023-04-12T02:26:47Z
dc.date.issued2017-08-01
dc.description.abstractThe immune stimulating effects of the methanolic extract of black cumin (Nigella sativa) in rainbow trout (Oncorhynchus mykiss) was evaluated. Variable concentrations of black cumin methanolic extract [0 (Control), 0.1 and 0.5 g kg−1 of feed] were individually added to the basal diet and rainbow trout was fed for 30 days to assess the innate immune responses and growth performance. Feed conversion ratio significantly decreased in the group fed with 0.5 g kg−1 black cumin extract. Respiratory burst activity was observed to be the highest in the 0.5 g kg−1 black cumin extract fed group. Lysozyme and myeloperoxidase activities were significantly increased in fish of experimental groups compared to control (P < 0.05). TGF-β gene expression increased in black cumin 0.5 g kg−1 treated group. IL-1β and TGF-β gene expressions decreased in black cumin 0.1 g kg−1 administered group. Expression of IL-12 gene diminished in both the experimental groups. There was no significant difference in survival rates between black cumin extract treated fish groups and control (P > 0.05) after challenged with Aeromonas hydrophila. The results indicate that the methanolic extract of black cumin is a stimulator of some innate humoral immune responses, but it is ineffective for cytokine-related gene trancriptions in rainbow trout.
dc.identifier.doi10.1016/j.fsi.2017.06.002
dc.identifier.issn10504648
dc.identifier.pubmed28602677
dc.identifier.scopus2-s2.0-85020296521
dc.identifier.urihttps://hdl.handle.net/20.500.12597/5493
dc.relation.ispartofFish and Shellfish Immunology
dc.rightsfalse
dc.subjectBlack cumin methanolic extract | Cytokine response | Growth promotion | Immunostimulant | Rainbow trout
dc.titleImmune responses to methanolic extract of black cumin (Nigella sativa) in rainbow trout (Oncorhynchus mykiss)
dc.typeArticle
dspace.entity.typeScopus
oaire.citation.volume67
person.affiliation.nameKastamonu University
person.affiliation.nameKastamonu University
person.affiliation.nameKastamonu University
person.affiliation.nameICAR - Central Institute of Brackishwater Aquaculture, Chennai
person.identifier.orcid0000-0001-9459-8178
person.identifier.scopus-author-id56046417100
person.identifier.scopus-author-id25229655300
person.identifier.scopus-author-id57194799184
person.identifier.scopus-author-id12779674400
relation.isPublicationOfScopus2a27ac43-b621-4dbe-8256-c29492b9f584
relation.isPublicationOfScopus.latestForDiscovery2a27ac43-b621-4dbe-8256-c29492b9f584

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