Scopus:
Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study

dc.contributor.authorSemis H.S.
dc.contributor.authorKandemir F.M.
dc.contributor.authorCaglayan C.
dc.contributor.authorKaynar O.
dc.contributor.authorGenc A.
dc.contributor.authorArıkan S.M.
dc.date.accessioned2023-04-11T22:23:29Z
dc.date.accessioned2023-04-12T00:28:40Z
dc.date.available2023-04-11T22:23:29Z
dc.date.available2023-04-12T00:28:40Z
dc.date.issued2022-09-01
dc.description.abstractOxaliplatin (OXL) is a chemotherapeutic drug used for metastatic and other types of cancer, but it causes peripheral neuropathy as a dose-limiting side effect. Herein, we used the rat model of OXL-induced peripheral neuropathy to demonstrate the protective effects of naringin (NRG) in this neuropathy. In this study, rats were injected with OXL (4 mg/kg, body weight, i.p.) in 5% glucose solution 30 min after oral administration of NRG (50 and 100 mg/kg, body weight) on the 1st, 2nd, 5th, and 6th days. OXL caused sensory and motor neuropathy (as revealed by the hot plate, tail flick, rota-rod, and cold hyperalgesia tests) in the sciatic nerve of rats. Coadministration of oral NRG alleviated OXL-induced sensory and motor neuropathy. Levels of superoxide dismutase, catalase, glutathione peroxidase, nuclear factor erythroid 2-related factor 2, Heme oxygenase-1, nuclear factor-κ B, tumor necrosis factor-α, interleukin-1β, Bax, Bcl-2, caspase-3, paraoxonase, mitogen-activated protein kinase 14, neuronal nitric oxide synthase (nNOS), acetylcholinesterase, and arginase 2 in the sciatic nerve tissues were assessed by real-time polymerase chain reaction. Moreover, the protein levels of caspase-3, Bax, Bcl-2, intercellular adhesion molecules-1, glial fibrillary acidic protein, and nNOS were examined by Western blot analysis. NRG treatment significantly improved all the above-mentioned parameters and reduced OXL-induced oxidative stress, inflammation, and apoptosis in the sciatic nerve tissue. In conclusion, this study demonstrated that NRG significantly attenuated OXL-induced peripheral neuropathy and might be considered as a new protective agent to prevent the OXL-induced peripheral neuropathy.
dc.identifier.doi10.1002/jbt.23121
dc.identifier.issn10956670
dc.identifier.pubmed35670529
dc.identifier.scopus2-s2.0-85131292937
dc.identifier.urihttps://hdl.handle.net/20.500.12597/3718
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.rightsfalse
dc.subjectapoptosis | inflammation | oxaliplatin | oxidative stress | peripheral neuropathy
dc.titleProtective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study
dc.typeArticle
dspace.entity.typeScopus
oaire.citation.issue9
oaire.citation.volume36
person.affiliation.namePrivate Buhara Hospital
person.affiliation.nameAksaray Üniversitesi
person.affiliation.nameBingöl Üniversitesi
person.affiliation.nameKastamonu University
person.affiliation.nameBingöl Üniversitesi
person.affiliation.nameGazi University, Faculty of Medicine
person.identifier.orcid0000-0001-9912-174X
person.identifier.orcid0000-0002-8490-2479
person.identifier.orcid0000-0001-5608-554X
person.identifier.orcid0000-0001-5367-0743
person.identifier.orcid0000-0003-0376-5589
person.identifier.scopus-author-id57323277300
person.identifier.scopus-author-id27368037600
person.identifier.scopus-author-id57191202853
person.identifier.scopus-author-id16425824400
person.identifier.scopus-author-id57221109954
person.identifier.scopus-author-id57208164777
relation.isPublicationOfScopus41a6d637-dcfc-4b86-a4ea-d622ea87d205
relation.isPublicationOfScopus.latestForDiscovery41a6d637-dcfc-4b86-a4ea-d622ea87d205

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