Scopus: Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats
dc.contributor.author | Tekeli I.O. | |
dc.contributor.author | Turk E. | |
dc.contributor.author | Durna Corum D. | |
dc.contributor.author | Corum O. | |
dc.contributor.author | Kirgiz F.C. | |
dc.contributor.author | Sakin F. | |
dc.contributor.author | Uney K. | |
dc.date.accessioned | 2023-04-12T01:21:07Z | |
dc.date.available | 2023-04-12T01:21:07Z | |
dc.date.issued | 2020-09-01 | |
dc.description.abstract | The pharmacokinetics of cefquinome (2 mg/kg every 24 hr for 5 days) was determined following intramuscular administration alone and co-administration with ketoprofen (3 mg/kg every 24 hr for 5 days) in goats. Six goats were used for the study. In the study, the crossover pharmacokinetics design with 20-day washout period was performed in two periods. Plasma concentrations of cefquinome were assayed using high-performance liquid chromatography by ultraviolet detection. The mean terminal elimination half-life (t1/2ʎz), area under the concentration–time curve (AUC0–24), peak concentration (Cmax), apparent volume of distribution (Vdarea/F), and total body clearance (CL/F) of cefquinome after the administration alone were 4.85 hr, 11.06 hr*µg/ml, 2.37 µg/mL, 1.23 L/kg, and 0.17 L/h/kg after the first dose, and 5.88 hr, 17.01 hr*µg/mL, 3.04 µg/mL, 0.95 L/kg, and 0.11 L/h/kg after the last dose. Ketoprofen significantly prolonged t1/2ʎz of cefquinome, increased AUC0–24 and Cmax, and decreased Vdarea/F and CL/F. Cefquinome exhibited low accumulation after the administration alone and in combination with ketoprofen. These results indicated that ketoprofen prolonged the elimination of cefquinome in goats. The 24-hr dosing intervals at 2 mg/kg dose of cefquinome, which co-administered with ketoprofen, may maintain T> minimum inhibitory concentration (MIC) values above 40% in the treatment of infections caused by susceptible pathogens with the MIC value of ≤0.75 μg/ml in goats with an inflammatory condition. | |
dc.identifier.doi | 10.1111/jvp.12904 | |
dc.identifier.issn | 01407783 | |
dc.identifier.pubmed | 32815194 | |
dc.identifier.scopus | 2-s2.0-85089693109 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/4693 | |
dc.relation.ispartof | Journal of Veterinary Pharmacology and Therapeutics | |
dc.rights | false | |
dc.subject | Cefquinome | goat | ketoprofen | pharmacokinetics | repeated dose | |
dc.title | Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats | |
dc.type | Article | |
dspace.entity.type | Scopus | |
oaire.citation.issue | 5 | |
oaire.citation.volume | 43 | |
person.affiliation.name | University of Hatay Mustafa Kemal | |
person.affiliation.name | University of Hatay Mustafa Kemal | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | University of Hatay Mustafa Kemal | |
person.affiliation.name | University of Hatay Mustafa Kemal | |
person.affiliation.name | Selçuk Üniversitesi | |
person.identifier.orcid | 0000-0002-6845-2279 | |
person.identifier.orcid | 0000-0003-1735-1774 | |
person.identifier.orcid | 0000-0003-1567-991X | |
person.identifier.orcid | 0000-0003-3168-2510 | |
person.identifier.orcid | 0000-0002-8454-5336 | |
person.identifier.orcid | 0000-0001-5377-0322 | |
person.identifier.orcid | 0000-0002-8674-4873 | |
person.identifier.scopus-author-id | 57190766109 | |
person.identifier.scopus-author-id | 57202784347 | |
person.identifier.scopus-author-id | 57204288970 | |
person.identifier.scopus-author-id | 55902904600 | |
person.identifier.scopus-author-id | 57218326819 | |
person.identifier.scopus-author-id | 14037995800 | |
person.identifier.scopus-author-id | 8408064700 | |
relation.isPublicationOfScopus | 366a4d89-78f5-45fd-aa3c-e41193d8e09b | |
relation.isPublicationOfScopus.latestForDiscovery | 366a4d89-78f5-45fd-aa3c-e41193d8e09b |