Scopus: Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous
dc.contributor.author | Altan F. | |
dc.contributor.author | Corum O. | |
dc.contributor.author | Corum D.D. | |
dc.contributor.author | Atik O. | |
dc.contributor.author | Uney K. | |
dc.date.accessioned | 2023-04-12T02:15:22Z | |
dc.date.available | 2023-04-12T02:15:22Z | |
dc.date.issued | 2018-02-01 | |
dc.description.abstract | In this study, the pharmacokinetic disposition and bioavailability of marbofloxacin (MB) were determined in lambs after single intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations at a dose of 3 mg/kg. The plasma concentration of MB was measured using high-performance liquid chromatography-UV, and the pharmacokinetic parameters were analyzed using a non-compartmental analysis. Following IV, IM, and SC administrations, the mean terminal half-life (t1/2ʎz) was 11.48, 12.64, and 24.86 h, respectively, and the mean residence time (MRT) was 7.27, 7.81, and 10.11 h, respectively. The bioavailability (F) was 96.01 and 126.39%, after IM and SC administration, respectively. This study showed that SC administration of MB at a dose of 3 mg/kg exhibited flip-flop pharmacokinetics in lambs. These results suggested that MB could be useful in the treatment of severe systemic infections, such as those with M. haemolytica (MIC = 0.035 μg/mL), in lambs since high AUC0-24/MIC and Cmax/MIC ratios were achieved after IV and IM administration at 3 mg/kg. However, MB administration (3 mg/kg) via the IV, IM, and SC routes might not be effective in the treatment of respiratory infections caused by organisms with MIC90 value in lambs. | |
dc.identifier.doi | 10.1016/j.smallrumres.2017.12.004 | |
dc.identifier.issn | 09214488 | |
dc.identifier.scopus | 2-s2.0-85037992216 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/5330 | |
dc.relation.ispartof | Small Ruminant Research | |
dc.rights | false | |
dc.subject | Fluoroquinolones | Lamb | Marbofloxacin | Pharmacokinetics | |
dc.title | Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous | |
dc.type | Article | |
dspace.entity.type | Scopus | |
oaire.citation.volume | 159 | |
person.affiliation.name | Dicle Üniversitesi | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Selçuk Üniversitesi | |
person.affiliation.name | Selçuk Üniversitesi | |
person.identifier.scopus-author-id | 26433107400 | |
person.identifier.scopus-author-id | 55902904600 | |
person.identifier.scopus-author-id | 57204288970 | |
person.identifier.scopus-author-id | 57199403375 | |
person.identifier.scopus-author-id | 8408064700 | |
relation.isPublicationOfScopus | 4c5136e2-fe2f-4a8d-8559-e88a3cf487db | |
relation.isPublicationOfScopus.latestForDiscovery | 4c5136e2-fe2f-4a8d-8559-e88a3cf487db |