Scopus:
Evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives

dc.contributor.authorRamadan M.A.G.
dc.contributor.authorBaloglu M.C.
dc.contributor.authorAltunoglu Y.C.
dc.contributor.authorKandemirli F.
dc.contributor.authorBurhan H.
dc.contributor.authorAygün A.
dc.contributor.authorSayiner H.S.
dc.contributor.authorOzyigit F.
dc.contributor.authorŞen F.
dc.date.accessioned2023-04-12T01:23:57Z
dc.date.available2023-04-12T01:23:57Z
dc.date.issued2020-06-01
dc.description.abstractIsatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gramnegative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.
dc.identifier.doi10.22052/JNS.2020.03.007
dc.identifier.issn22517871
dc.identifier.scopus2-s2.0-85091853796
dc.identifier.urihttps://hdl.handle.net/20.500.12597/4733
dc.relation.ispartofJournal of Nanostructures
dc.rightsfalse
dc.subject5-Fluoro-Isatin | Antimicrobial activity | DNA protection | Thiosemicarbazone
dc.titleEvaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives
dc.typeArticle
dspace.entity.typeScopus
oaire.citation.issue3
oaire.citation.volume10
person.affiliation.nameKastamonu University
person.affiliation.nameKastamonu University
person.affiliation.nameKastamonu University
person.affiliation.nameKastamonu University
person.affiliation.nameDumlupinar Üniversitesi
person.affiliation.nameDumlupinar Üniversitesi
person.affiliation.nameAdiyaman Üniversitesi
person.affiliation.nameKütahya Sağlık Bilimleri Üniversitesi
person.affiliation.nameDumlupinar Üniversitesi
person.identifier.scopus-author-id57219247778
person.identifier.scopus-author-id36766861600
person.identifier.scopus-author-id56046417100
person.identifier.scopus-author-id6602393314
person.identifier.scopus-author-id57202991545
person.identifier.scopus-author-id57195693468
person.identifier.scopus-author-id53164852600
person.identifier.scopus-author-id12040087600
person.identifier.scopus-author-id8449363400
relation.isPublicationOfScopus3c3e13d0-7b0e-41b7-afdf-74fa0aa5d628
relation.isPublicationOfScopus.latestForDiscovery3c3e13d0-7b0e-41b7-afdf-74fa0aa5d628

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