Scopus: Evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives
dc.contributor.author | Ramadan M.A.G. | |
dc.contributor.author | Baloglu M.C. | |
dc.contributor.author | Altunoglu Y.C. | |
dc.contributor.author | Kandemirli F. | |
dc.contributor.author | Burhan H. | |
dc.contributor.author | Aygün A. | |
dc.contributor.author | Sayiner H.S. | |
dc.contributor.author | Ozyigit F. | |
dc.contributor.author | Şen F. | |
dc.date.accessioned | 2023-04-12T01:23:57Z | |
dc.date.available | 2023-04-12T01:23:57Z | |
dc.date.issued | 2020-06-01 | |
dc.description.abstract | Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gramnegative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity. | |
dc.identifier.doi | 10.22052/JNS.2020.03.007 | |
dc.identifier.issn | 22517871 | |
dc.identifier.scopus | 2-s2.0-85091853796 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/4733 | |
dc.relation.ispartof | Journal of Nanostructures | |
dc.rights | false | |
dc.subject | 5-Fluoro-Isatin | Antimicrobial activity | DNA protection | Thiosemicarbazone | |
dc.title | Evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives | |
dc.type | Article | |
dspace.entity.type | Scopus | |
oaire.citation.issue | 3 | |
oaire.citation.volume | 10 | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Kastamonu University | |
person.affiliation.name | Dumlupinar Üniversitesi | |
person.affiliation.name | Dumlupinar Üniversitesi | |
person.affiliation.name | Adiyaman Üniversitesi | |
person.affiliation.name | Kütahya Sağlık Bilimleri Üniversitesi | |
person.affiliation.name | Dumlupinar Üniversitesi | |
person.identifier.scopus-author-id | 57219247778 | |
person.identifier.scopus-author-id | 36766861600 | |
person.identifier.scopus-author-id | 56046417100 | |
person.identifier.scopus-author-id | 6602393314 | |
person.identifier.scopus-author-id | 57202991545 | |
person.identifier.scopus-author-id | 57195693468 | |
person.identifier.scopus-author-id | 53164852600 | |
person.identifier.scopus-author-id | 12040087600 | |
person.identifier.scopus-author-id | 8449363400 | |
relation.isPublicationOfScopus | 3c3e13d0-7b0e-41b7-afdf-74fa0aa5d628 | |
relation.isPublicationOfScopus.latestForDiscovery | 3c3e13d0-7b0e-41b7-afdf-74fa0aa5d628 |