Scopus:
Collagen/Beta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing

dc.contributor.authorSarikaya B.
dc.contributor.authorAydin H.M.
dc.date.accessioned2023-04-12T02:51:41Z
dc.date.available2023-04-12T02:51:41Z
dc.date.issued2015-01-01
dc.description.abstractMillions of patients worldwide remain inadequately treated for bone defects related to factors such as disease or trauma. The drawbacks of metallic implant and autograft/allograft use have steered therapeutic approaches towards tissue engineering solutions involving tissue regeneration scaffolds. This study proposes a composite scaffold with properties tailored to address the macro- and microenvironmental conditions deemed necessary for successful regeneration of bone in defect areas. The biodegradable scaffold composed of porous beta-tricalcium phosphate particles and collagen type I fibers is prepared from a mixture of collagen type-I and β-tricalcium phosphate (β-TCP) particles via lyophilization, followed by dehydrothermal (DHT) processing. The effects of both sterilization via gamma radiation and the use of DHT processing to achieve cross-linking were investigated. The impact of the chosen fabrication methods on scaffold microstructure and β-TCP particle-collagen fiber combinations were analyzed using X-ray diffractometry (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and microcomputerized tomography (μ-CT). Electron spinning resonance (ESR) analysis was used to investigate free radicals formation following sterilization. Results revealed that the highly porous (65% porosity at an average of 100 μm pore size), mechanically adequate, and biocompatible scaffolds can be utilized for bone defect repairs.
dc.identifier.doi10.1155/2015/576532
dc.identifier.issn23146133
dc.identifier.pubmed26504812
dc.identifier.scopus2-s2.0-84945278135
dc.identifier.urihttps://hdl.handle.net/20.500.12597/5818
dc.relation.ispartofBioMed Research International
dc.rightstrue
dc.titleCollagen/Beta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing
dc.typeArticle
dspace.entity.typeScopus
oaire.citation.volume2015
person.affiliation.nameHacettepe Üniversitesi
person.affiliation.nameBMT Calsis Health Technologies Co.
person.identifier.scopus-author-id56924968400
person.identifier.scopus-author-id7004834667
relation.isPublicationOfScopusa34c7939-04ed-4ef5-8fb7-3ad46c36a835
relation.isPublicationOfScopus.latestForDiscoverya34c7939-04ed-4ef5-8fb7-3ad46c36a835

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