Pubmed: Evaluation of the Roflumilast Effect Supplemented with Linezolid in Pleural Empyema in Rats Caused by Intrapleural Staphylococcus aureus Inoculation.
dc.contributor.author | Kerget, Buğra | |
dc.contributor.author | Araz, Ömer | |
dc.contributor.author | Kerget, Ferhan | |
dc.contributor.author | Erol, Hüseyin Serkan | |
dc.contributor.author | Özmen, Sevilay | |
dc.contributor.author | Halıcı, Zekai | |
dc.contributor.author | Akgün, Metin | |
dc.date.accessioned | 2023-04-07T02:21:03Z | |
dc.date.available | 2023-04-07T02:21:03Z | |
dc.date.issued | 2020-01-23T00:00:00Z | |
dc.description.abstract | In addition to tube drains, pleural empyema is treated with antibiotics and anti-inflammatory drugs. We aimed to evaluate the anti-inflammatory activity of roflumilast combined with linezolid in a rat model of pleural empyema induced by Staphylococcus aureus. A total of 40 rats were divided into 7 groups: sham (n = 4), S. aureus inoculation (n = 6), S. aureus + 10 mg/kg linezolid (n = 6), S. aureus + 5 mg/kg roflumilast (n = 6), S. aureus + 10 mg/kg linezolid + 5 mg/kg roflumilast (n = 6), S. aureus + 10 mg/kg roflumilast (n = 6), and S. aureus + 10 mg/kg linezolid + 10 mg/kg roflumilast (n = 6). Animals were administered linezolid 1 h before and 12 h after inoculation with S. aureus. Roflumilast was administered orally as a single dose 30 min before inoculation with S. aureus. Compared to linezolid treatment alone, linezolid combined with 5 mg/kg roflumilast significantly improved TNF-α, IL-1β, vasodilation/congestion, and tissue/pleural polynuclear leukocyte (PNL) infiltration (p < 0.05). Linezolid combined with 10 mg/kg roflumilast also provided a significant improvement in TNF-α, IL-1β, IL-6, endothelin-1, vasodilation/congestion, mesothelial cell damage, lung tissue PNL, and pleural PNL compared to linezolid alone (p < 0.05). Due to its anti-inflammatory effects and significant impact on recovery, roflumilast can be used in conjunction with antibiotherapy for the treatment of pleural empyema. | |
dc.identifier.doi | 10.7883/yoken.JJID.2019.164 | |
dc.identifier.issn | 1884-2836 | |
dc.identifier.pubmed | 31474702 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/3486 | |
dc.language.iso | en | |
dc.relation.ispartof | Japanese journal of infectious diseases | |
dc.subject | linezolid | |
dc.subject | lung tissue | |
dc.subject | pleural empyema | |
dc.subject | treatment | |
dc.title | Evaluation of the Roflumilast Effect Supplemented with Linezolid in Pleural Empyema in Rats Caused by Intrapleural Staphylococcus aureus Inoculation. | |
dc.type | Journal Article | |
dspace.entity.type | Pubmed | |
oaire.citation.issue | 1 | |
oaire.citation.volume | 73 | |
relation.isPublicationOfPubmed | 1d84753b-6aa2-49ec-bc0d-0fade0b0aabb | |
relation.isPublicationOfPubmed.latestForDiscovery | 1d84753b-6aa2-49ec-bc0d-0fade0b0aabb |