Pubmed İndekslenen Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12597/3195

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Dietary Effect of Withania somnifera Root Powder on Growth, Hematobiochemical Parameters, Immunity, and Disease Resistance to Aeromonas hydrophila in Cyprinus carpio
(2024) Habib, S.S.; Saeed, M.Q.; Masud, S.; Kesbiç, O. S.; Ujan, J.A.; Cravana, C.; Al-Rejaie, S. S; Mohany, M.; Fazio, F.
This study investigates the influence of root powder (WSRP) on different aspects of common carp (), including growth, hematobiochemical parameters, antioxidant status, nonspecific immune response, and resilience to bacterial infections. Over a 60-day period, 180 common carp fingerlings (11.73 ± 0.52 g) were subjected to diets supplemented with increasing WSRP levels (0 (control), 1% (WSRP1), 2.5% (WSRP2.5), and 4% (WSRP4)). Nonspecific immune parameters were evaluated using serum samples collected at intervals of 0, 20, 40, and 60 days. After the feeding trial, the fish underwent experimental challenge with , and relative percentage survival (RPS) was monitored for 14 days. The findings revealed a considerable ( < 0.05) enhancement in growth performance and a decreased feed conversion ratio (FCR) with increasing WSRP supplementation. Additionally, hematological and biochemical profiles exhibited improvements in groups receiving WSRP-enriched diets. Fish serum antioxidant status showed a significant ( < 0.05) increase, as indicated by increased activities of total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in WSRP4. WSRP-supplemented diets led to remarkable enhancements in lysozyme activity ( = 0.001), phagocytic activity ( = 0.002), and RPS ( = 0.003), peaking in WSRP4 at day 60. Furthermore, WSRP2.5 and WSRP4 demonstrated a substantial decrease ( > 0.05) in serum glucose and cortisol levels compared to other groups. In conclusion, WSRP proves valuable for enhancing growth, blood parameters, antioxidant balance, immune response, and infection resistance in common carp, especially at 2.5%-4% dietary supplementation levels. In the future, it will be crucial to study the long-term effects of WSRP supplementation on fish health, as well as its potential for large-scale aquaculture and economic viability in the aquafeed industry.
Nettle (Urtica dioica) supplementation: impact on growth, hematology, immune response, and resilience to Aeromonas hydrophila in Labeo rohita fingerlings
(2024) Ujan, J. A.; Raza, A.; Habib, S. S.; Athar, R.; Kesbiç, O. S.; Batool, A. I.; Habib, S. F.; Mohany, M.; Fazio, F.
The significance of plant-derived products in aquaculture lies in their potential to offer sustainable alternatives, promoting eco-friendly practices. This study investigated the impact of nettle (Urtica dioica) leaves powder on the growth efficiency, hemato-biochemical variables and non-specific immune system of rohu, Labeo rohita fingerlings. To achieve this objective, sample average weight (5.23 ± 0.34 g) were categorized into four groups, namely control, T1, T2 and T3 in triplicate and administered diets fortified with nettle in amounts of 0, 1, 3 and 5% respectively for a duration of 60 days. After 60 days of fortified diet, the fish underwent intraperitoneal injection with bacteria (Aeromonas hydrophila), and subsequent relative percentage survival (RPS) was observed. The growth performance, including "weight gain (WG), specific growth rate (SGR), feed conversion ratio (FCR) and feed efficiency ratio (FER)", were notably higher in the T3 group (5%) than in others. The hematological values of White blood cell, hematocrit, and hemoglobin revealed higher levels with a fortified diet. The dietary supplementation of nettle reduced serum cholesterol and glucose concentration, whereas it increased albumin, globulin, and total protein in the fish blood. Enhancements in lysozyme and myeloperoxidase activity were observed in the intervention groups with feed containing nettle supplementation. The nettle diet at a 5% concentration demonstrated a higher RPS than the others following injection with A. hydrophila. The findings indicate the potential of nettle as a valuable nutritional supplement for increasing fish immunological reaction and bolstering pathogen resistance.
Efficacy of intravitreal faricimab therapy for polypoidal choroidal vasculopathy: A systematic review and meta-analysis
(2024) Arnold-Vangsted, A.; Schou, M. G; Balaratnasingam, C.; Cehofski, L.J; Chhablani, J.; van Dijk, E. H C; Eriksen, N. S; Grauslund, J.; Hajari, J.N; Sabaner, M C.; Schneider, M.; Subhi, Y.
Polypoidal choroidal vasculopathy (PCV) is an aneurismal type of macular neovascularization that show similarities with age-related macular degeneration and diseases that are part of the pachychoroid disease spectrum. Exudative changes in PCV can be treated with intravitreal anti-vascular endothelial growth factor monotherapy; however, a combination therapy with photodynamic therapy may be required. In this systematic review and meta-analysis, we evaluated the efficacy of faricimab for PCV. We searched 12 literature databases for eligible studies. All study evaluation and data extraction were made by two authors in duplicate. Studies eligible for analysis were included for a qualitative and quantitative review. We identified seven studies with data from 150 eyes with PCV, five studies were of treatment-naïve eyes who were commenced in faricimab monotherapy, and two studies were of switch-over to faricimab from other anti-VEGF drugs. After faricimab loading dose in treatment-naïve eyes, the best-corrected visual acuity (BCVA) remained stable at -0.09 (95% CI: -0.20-0.03) logMAR, central retinal thickness (CRT) decreased -169 (95% CI: -311--27) μm, and 48.7 (95% CI: 32.5-65.0) % of eyes obtained polyp closure. In switch-over eyes, 57%-67% experienced fluid reduction and 21% were able to extend their treatment interval. In conclusion, faricimab monotherapy for PCV leads to acceptable clinical outcomes in terms of stable BCVA, reduction of CRT, and high incidence of polyp closure. Some cases may benefit from a switch to faricimab. However, long-term efficacy studies and controlled comparative studies are warranted.
Environmental effects of acid mine drainage and rehabilitation options at closed mine site: a case study
(2024) Konanç, M.U.; Değermenci, G.D.
Irregular waste storage at closed mine sites poses severe environmental problems. This study evaluates the concentrations and effects of trace elements released into the environment by mining activity by analyzing soil, water, and sediment samples taken from a copper mining site. According to the data, acidic mine drainage was the main cause of the high concentrations of trace elements in the soil and sediments, including arsenic (As), cadmium (Cd), lead (Pb), and copper (Cu). The concentrations of As, Cd, Pb, and Cu in soil and sediments were 2734-times, 1189-times, 157-times and 32 times higher, respectively, in comparison to the background values of averaged concentrations of these elements in the upper crust. Geological and statistical studies indicate that the primary constituents of these pollutants are chalcopyrite and pyrite derivatives present in the primary rock structure. Using water analysis data from 2011 to 2020, the release of essential trace element into water was investigated to monitor the environmental effects of acidic mine drainage (AMD) from the closed Kuvarshan copper mine in the Artvin region of Turkey. This study demonstrates that trace elements concentrations may change according to local and seasonal factors and highlights the importance of conducting routine environmental monitoring studies.
Preliminary Study on the Impact of 900MHz Radiation on Human Sperm: An In Vitro Molecular Approach
(2024) Keskin, I.; Karabulut, S.; Kaplan, A.A.; Alagöz, M.; Akdeniz, M.; Tüfekci, K.K.; Davis, D.L.; Kaplan, S.
The use of technologies that produce and emit electromagnetic fields (EMF) is growing exponentially worldwide. The biological effects of EMF-emitting equipment, such as mobile phones and other wireless devices, have been studied in the last decade using in vitro and in vivo methods. Infertility is a growing health problem, and nearly half of cases are because of male-factor. This study investigated the direct in vitro effects of 900MHz radiation exposure on sperm parameters, genetic status, apoptotic markers, and the PI3K/AKT signaling pathway in healthy normozoospermic men. Semen samples were divided into four groups, two control (30min and 1h) and two EMF exposure (30min and 1h). Sperm parameters (motility, progressive motility, acrosomal index, morphology), genetic status (DNA fragmentation and chromatin integrity), apoptotic markers (cytokine-c and caspase-3 expression) and the PI3K/AKT signaling pathway (phosphoinoitide 3-kinase-PI3K- and phosphorylated AKT- p-AKT-) were analysed. Sperm motility were significantly reduced in 30min EMF exposure while a significant increase in the expression of p-AKT were observed in 1h EMF exposure group. An increased vacuolisation, acrosomal defect, extension of subacrosomal space, uncondensed chromatin structure, apoptotic signs and disrupted axoneme were observed in both EMF groups which were not observed in the control group. Other sperm parameters (morphology and acrosomal index), genetic status, apoptotic markers and the PI3K expression rates had no significant change.
Simultaneous clavicular hook plate fixation in bilateral distal clavicle fractures (Neer type II): A case report
(2024) Akar, B.; Ugur, F.
Rationale: Bilateral distal clavicle fractures (BDCF) are exceedingly rare types of fractures. This study aimed to evaluate the surgical treatment under a single anesthesia for trauma-induced BDCF (Neer type II) through a case report. Patient concerns: The patient brought to the emergency department due to a motor vehicle accident exhibited severe pain, tenderness, swelling, and deformity in both shoulder regions upon physical examination. No significant pain or tenderness was detected in other areas of the body. There were also no signs of additional neurological deficits or vascular pathology in the extremities. Diagnoses: Radiographic examinations led to a diagnosis of BDCF (Neer type II). Interventions: Surgical intervention involved the simultaneous application of a neutral-angled hook plate to both clavicles via open reduction. Outcomes: Postoperative radiographs taken at the 12th week demonstrated complete healing in both fractures and no functional limitations in shoulder movements. Lessons: BDCF can compromise the stability of the shoulder girdle, necessitating surgical intervention with anatomical reduction and rigid fixation.
The Role of Hearing Aids in Improving Dual-Task Gait Performance in Older Adults With Presbycusis: A Cognitive and Motor Analysis
(2024) Soylemez, E.; Soylemez, T.G.; Apaydin, A.S.; Apaydin, Z.K.; Yasar, M.
Background: Cognitive decline is a common challenge faced by older individuals with presbycusis; their performance on dual-task (DT) activities is generally lower compared to those without hearing loss. However, the influence of hearing aids on nonauditory cognitive decline in this population remains unclear. This study aims to investigate the effect of hearing aids on nonauditory DT performance in older adults with presbycusis. Material and methods: This study included older people with presbycusis who used hearing aids (P&HA group), those with presbycusis who did not use hearing aids (PoHA group), and a control group of healthy adults. Forward and backward digit span tests and timed up and go test (TUG) were administered to all individuals. TUG and motor and cognitive (forward and backward digit span) tasks were applied simultaneously to evaluate the participants' DT performance. Results: The study comprised 60 individuals with presbycusis (19 females, 41 males; mean age: 73.23 ± 6.49 years) and 30 healthy adults (15 females, 15 males; mean age: 35.93 ± 8.57 years). Healthy adults performed better than the P&HA and PoHA groups in all the administered tests (p < 0.05). There was a moderate negative relationship between the severity of hearing loss and the forward and backward digit span test performances (p < 0.05). The P&HA group performed better than the PoHA group on the DT cognitive forward and backward digit span tests. Conclusion: The use of hearing aids and their proper fitting are important not only for improving communication skills and reducing listening effort but also for supporting nonauditory cognitive functions, minimizing the risk of falls during DT activities, and enhancing the overall quality of life.
Ameliorative effects of humic acid and L-tryptophan on enzyme activity, mineral content, biochemical properties, and plant growth of spinach cultivated in saline conditions
(2024) Turfan, N.; Kibar, B.; Davletova, N.; Kibar, H.
Salinity poses a significant abiotic stress that limits plant productivity, thereby posing a serious threat to agricultural sustainability and worldwide food security. Techniques that can overcome this problem are needed. Recent focus has been placed on employing organic substances like humic acid (HA) and amino acids, including L-tryptophan (L-TRP), to mitigate the negative effects of salt stress on cultivated plants. Accordingly, in this research, the impact of foliar applications of HA and L-TRP, both separately and combined, on the growth parameters and biochemical properties of spinach subjected to salt stress was investigated. In the present study, eight treatments (1. control, 2. salt (NaCl), 3. HA, 4. L-TRP, 5. HA + NaCl, 6. L-TRP + NaCl, 7. HA + L-TRP, and 8. HA + L-TRP + NaCl) were investigated. The study showed that salt stress markedly reduced several growth properties in spinach, including plant height, number of leaves, leaf dimensions, and both fresh and dry weight. Additionally, it significantly lowered contents of chlorophyll (, , and total), carotenoid, polyphenol, lutein, anthocyanin, polyphenol oxidase, glycine betaine, relative water content, and the antioxidant enzyme activities (ascorbate peroxidase, catalase, peroxidase, and superoxide dismutase). On the other hand, significant increases were observed in sodium, chlorine, potassium, sulfur, zinc, nickel, proline, malondialdehyde, and hydrogen peroxide levels of spinach with salinity. Individual and combined applications of HA and L-TRP positively influenced plant growth, relative water content, activities of antioxidant enzyme, chlorophyll, and mineral contents of spinach under both normal and saline conditions. In conclusion, the combined use of HA and L-TRP under salt stress conditions is promising in mitigating the negative impacts of salinity and can be suggested as an effective alternative approach for cultivating spinach in saline environments.
Evaluation of Some Potentially Toxic Elements and Associated Ecological and Health Risks in Topsoil Samples Adjacent to an Industrial Zone in Turkey
(2024) Altıkulaç, A.; Turhan, Ş.
Potentially toxic element (PTE) pollution as a result of industrial activities remains a global problem that poses serious threats to human and ecological health. PTEs (Al, Fe, Ti, Mn, V, Zn, Cu, Cr, Ni, Pb, Co, and As) are metals or metalloids with biological toxicity. This study analyzed the concentrations of these PTEs and the physicochemical properties of topsoil samples collected from areas near industrial districts in the Samsun province of Turkey to evaluate ecological and health risks, estimating various indexes. The average concentrations of Al, Fe, Ti, Mn, V, Zn, Cu, Cr, Ni, Pb, Co, and As analyzed in 23 topsoil samples by energy-dispersive X-ray fluorescence spectrometry were found as 93,822, 82,410, 6623, 1642, 406, 278, 207, 149, 78, 68, 32, and 10 mg/kg dry weight, respectively. Zn, Cu, Cr, Ni, Pb, and Co levels exceed the maximum contaminant levels in the Turkish Regulation on the Control of Soil Pollution. The average pH values, organic matter, total organic carbon, and nitrogen measured in soil samples were 7.14, 6.11, 0.96, and 0.04%, respectively. The ecological and health evaluation reveals that the studied area is polluted with V, Cu, Zn, As, Ni, and Pb, which may pose a risk to people living in settlements near the industrial district.
The Effects of Pregnancy Status on Lacrimal Caruncle Temperature, Intraocular Pressure and Rectal Temperature in Cats: A Preliminary Study
(2024) Ozcan, C.; Safak, T.; Dellalbasi, A.B.; Dogan, E.
Objective: The objectives of this study were to compare the body temperatures between pregnant and nonpregnant cats from two sites, lacrimal caruncle temperature (LCT) and rectal temperature (RT), and to compare intraocular pressure (IOP) between pregnant and nonpregnant cats. Animal studied: This study was performed on 13 pregnant and 16 anoestrous cats. Procedures: The gestation period of the pregnant cats ranged from 20 to 45 days. A vaginal smear was also performed to determine the sexual cycles of nonpregnant cats. The IOP was measured using a rebound tonometer. Results: The pregnant cats (38 ± 0.7°C) exhibited a lower RT than the nonpregnant cats (38.5 ± 0.5°C) (p < 0.05). No significant differences existed between the pregnant and nonpregnant groups in the right (R)-LCT or left (L)-LCT (p > 0.05). The average LCT temperature measured 32.30 ± 2.23°C in cats. The right (R)-IOP in pregnant cats (17.69 ± 5.6 mm Hg) was significantly lower than in nonpregnant cats (22.37 ± 5.27 mm Hg) (p < 0.029). Pregnant cats exhibited a significantly lower left (L)-IOP value (17.69 ± 5.76 mm Hg) compared to nonpregnant cats (23.18 ± 5.55 mm Hg) (p < 0.015). Conclusion: This study presents a preliminary report that documents a noteworthy reduction in RT in pregnant cats (38 ± 0.7°C) as compared to cats in anoestrus. Pregnancy also has an effect on the IOP. It was hypothesised that the hormonal changes induced by pregnancy in cats would have a substantial impact on IOP and RT. Although body temperature can be measured using LCT, RT should still be utilised as the reference measurement site.
Evaluation of the Effect of Topical Prostaglandin Analog Treatment on Orbital Structures in Open-Angle Glaucoma with Computed Tomography
(2024) Ece, B.Ş.D.; Yozgat, Z.; Bayramlı, H.; Ece, B.; Aydin, S.
This study aims to evaluate the computed tomography (CT) scans of glaucoma patients using prostaglandin analogs (PGA) in one eye, investigate findings associated with prostaglandin-associated periorbitopathy (PAP), and compare these findings with those of the contralateral eyes. : Patients with open-angle glaucoma who had CT images of the orbital region taken for another reason at least one month after starting PGA treatment in one eye were included in the study. Enophthalmos measurements from thin-slice CT images, along with 3D volume measurements of orbital fat tissue, periorbital muscles, and the optic nerve, were performed. Ophthalmological examination findings and treatment information were collected. The values were compared with those of the contralateral eyes of the same patients not using PGA. Intraclass correlation coefficients (ICCs) were computed to evaluate measurement repeatability. : Forty patients were included in the study. Among them, 29 (72.5%) used latanoprost, 9 (22.5%) used bimatoprost, and 2 (5%) used travoprost. The mean enophthalmos values on the treated side (15.5 ± 2.0 mm) were lower than on the untreated side (16.1 ± 1.4 mm), but this difference was not statistically significant ( = 0.07). In 29 patients (72.5%), enophthalmos measurements were smaller on the treated side, with 7 patients (17.5%) showing a difference of 2 mm or more. No significant correlation was found between the duration of PGA use and enophthalmos measurements ( = 0.768 r = -0.048). Additionally, no significant differences were found in orbital fat volume, total extraocular muscle volume, and optic nerve volume ( > 0.05). ICC values demonstrated excellent reliability (ICC > 0.75) for all measurements. : We did not find significant differences in enophthalmos measurements, orbital fat volume, total muscle volume, and optic nerve volume between the PGA-treated and untreated eyes.
In vitro and in vivo effects of commercial and environmental microplastics on Unio delicatus
(2024) Yüce, P.A.; Günal, A.Ç.; Erkmen, B.; Dikmen, B.Y.; Çağan, A.S.; Çırak, T.; Kankılıç, G.B.; Seyfe, M.; Filazi, A.; Tavşanoğlu, Ü.N.
Microplastics (MPs) are ubiquitous pollutants in freshwater environments. In this study, freshwater mussels, Unio delicatus, were exposed to both environmental MPs (e-MP) and commercial MPs (c-MP) that include green fluorescent MP (gf-MP), polyethylene (c-PE) and polystyrene (c-PS) at environmental concentrations (5 mg/L and 50 mg/L) over duration of 7 and 30 days. According to in vivo experiment results, both e-MPs and c-MPs induced significant changes in the total hemocyte counts of mussels (p < 0.05). Exposure to high concentrations of e-MPs and c-MPs for 7 days led to decreased cellular glutathione levels in the mussels, while exposure to low concentrations of e-MPs and c-PS for 7 days resulted in increased advanced oxidation protein products (AOPP). Mussels exposed to high concentrations of e-MPs for 30 days exhibited decreases in both glutathione levels and AOPP values. Although no damage was observed in tissues other than gills and digestive gland, histopathological alterations were observed in these tissues following exposure to 50 mg/L c-MPs. Additionally, MPs were observed in the intestine tissues. In vitro experiments using the MTT assay showed no significant difference in cell viability between the MP-exposed group and the control group at tested concentrations, with no observed dose-response relationship (p > 0.05). Nevertheless, certain cells exhibited signs of cell death, such as disrupted cellular structures, condensed nuclei, and loss of cellular integrity. These observations were consistent with mechanical compression, indicating that physical contact with MPs may result in cell damage or death. These findings demonstrate that environmentally relevant concentrations of MPs have toxic effects on freshwater mussels and multiple parameters provide valuable insight for the evaluation of health risks of organisms.
Assessing Heavy Metal Contamination in Commonly Used Fertilizers for Polyculture Fish Ponds and Its Implications for Human Health: A Comprehensive Investigation.
(2024-10-12) Naz, Saira; Arshad, Madeeha; Majeed, Saima; Maqaddas, Sawera; Habib, Syed Sikandar; Kesbiç, Osman Sabri; Al-Rejaie, Salim S; Mohany, Mohamed; Bottari, Teresa; Aragona, Francesca; Fazio, Francesco
Over-fertilizing fish ponds can cause pollution, introducing heavy metals into the food chain and posing health risks. The present study investigated the incidence of heavy metals (Pb, Cu, Cd, and Cr) in commonly applied fertilizers, including nitrogen, phosphorus and potassium (NPK), triple superphosphate (TSP), and di-ammonium phosphate (DAP), and their association with heavy metals in water, sediment, and cultured fish species (Catla catla, Labeo rohita, and Cyprinus carpio) in polyculture fish ponds. The study was conducted over 4 months, with four groups in triplicates: control (no fertilizer), group 1 (NPK), group 2 (TSP), and group 3 (DAP). Heavy metal analysis was carried out using atomic absorption spectrophotometry before and after fertilizer application. Significantly (p < 0.05) higher levels of heavy metals were observed in water and sediment after applying fertilizers, with the most pronounced results in group 3 (DAP) followed by group 2 (TSP). The concentration of heavy metals was significantly (p < 0.05) higher in group 3 (DAP) fertilizers compared to other groups. Compared to the control, the concentration and bioaccumulation of heavy metals were significantly (p < 0.05) higher in the fertilizer-applied groups, with notably higher levels in group 3 (DAP). Cluster analysis and the correlation matrix did not show any significant association between the heavy metals and the fertilizers, indicating a complex interplay between the biotic and abiotic factors of the system. The health index (HI) value was < 1 in fish muscles of all studied groups, indicating the fish are safe for consumption. The study recommends monitoring and regulating fertilizer use, especially DAP, to prevent heavy metal contamination, and exploring sustainable alternatives to minimize environmental and health risks.
Toxic metal accumulation, health risk, and distribution in road dust from the urban traffic-intensive environment.
(2024-10-11) Isinkaralar, Oznur; Isinkaralar, Kaan; Nguyen, Tuyet Nam Thi
Owing to increasing levels of potentially toxic metals in road dust, air pollutants suspended in the air, pose significant health risks due to rapid, unplanned urbanization and industrialization. This study investigated the pollution status and health risks of trace metals (i.e., Cr, Cd, Ni, Cu, and Pb) in road dust collected from 16 locations across six land-use categories in Eskişehir, Türkiye, including residential, roadside, traffic, tram stations, and car industrial areas. The analysis of trace metals revealed distinct types of urban pollution based on these functional areas. In areas with heavy traffic, high concentrations of the elements, especially Zn, Cr, and Ni, would indicate significant toxic metal pollution. The overall contamination was evaluated using three indices: enrichment factor (EF 0.45-65.75), geo-accumulation index (I - 2.50-4.18), and pollution index (PI 0.27-27.22). Human health risks of potentially toxic trace metals in urban road dust were evaluated for children and adult groups based on hazardous index (HI) and total cancer risk (TCR). The health risk assessments revealed that children (mean HI 8.62E - 01; TCR 6.99E + 04) are more vulnerable to toxic metal exposure than adults (mean HI 1.01E - 01; TCR 3.01E + 04), with ingestion being the primary exposure route over dermal contact and inhalation. In conclusion, we have captured the interaction between road dust and health risks, especially for children.
Dynamic site index models sensitive to ecoregional variability for Scots pine stands in Western Black Sea Region of Türkiye.
(2024-10-08) Sağlam, Fadime; Sakici, Oytun Emre
Site productivity, defined as the production amount of the stand at a specific age, has a significant impact on the growth of the stand and site index is used as an indicator of site productivity. The objective of this study is to develop ecoregion-based dynamic site index models for Scots pine (Pinus sylvestris L.) stands in the Kastamonu and Sinop regions of Türkiye. The mixed-effects modeling approach allowing for the inclusion of ecoregions in the models was used to develop dynamic site index models, and the models derived from seven base models were tested. The best model was selected based on statistical criteria. As a result of statistical analyses and graphical examinations, the King-Prodan model was found to yield the best predictive results in terms of growth patterns. The site index model based on the King-Prodan method produced a coefficient of determination (R) of 0.977. The statistical criteria for this model are as follows: Akaike information criterion (AIC) of 4931.052, Bayesian information criterion (BIC) of 4968.933, root mean square error (RMSE) of 1.218, and mean error (ME) of - 0.036. The F-test was used to test whether there was a statistically significant difference in dominant heights between ecoregions. The results demonstrated that the dominant heights exhibited statistically significant differences among the ecoregions. Consequently, it is of paramount importance to utilize ecoregion-based dynamic site index models in order to achieve reliable and accurate predictions.
Chronotype, sleep quality, impulsivity and aggression in patients with borderline personality disorder and healthy controls
(2024) Taşdelen, Y.; İnaltekin, A.
Impulsivity, aggression, and suicide are the major clinical symptoms of borderline personality disorder (BPD). Although previous studies indicated poor sleep quality and its relationship with clinical symptoms in patients with BPD, chronotype, an important sleep parameter, was not investigated in these patients. This study aimed to analyze chronotype and its relationship with clinical symptoms in patients with BPD. Participants in this study consisted of 68 BPD patients and 65 healthy controls. Subjective sleep characteristics, impulsivity, aggression, suicide probability, and chronotype were assessed using the Pittsburgh Sleep Quality Index (PSQI), Barratt Impulsivity Scale, Buss-Perry Aggression Scale (BPAQ), Suicide Probability Scale, and Morningness - Eveningness Questionnaire, respectively. PSQI total and subscale scores subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, and daytime drowsiness were significantly higher in the BPD group ( < 0.001). There was a positive correlation between the PSQI total score and the BPAQ total score ( = 0.268, = 0.027). The rate of evening type was significantly higher in the control group ( = 0.004). Suicide attempts and the subscale of suicide probability hopelessness, suicidal ideation, and negative self-evaluation scores were significantly higher in evening type BPD patients. ( = 0.017, = 0.009, = 0.001, = 0.047). Sleep quality is associated with aggression, and the eveningness chronotype is associated with suicide. It may be useful to focus on sleep problems in treating BPD patients.
Cochlear Synaptopathy Evaluation With Electrocochleography in Patients With Hearing Difficulty in Noise Despite Normal Hearing Levels
(2024) Yaşar, M.; Öner, F.; Atalay, F.; Anbar, S.S.
Objective: This study examined patients with normal hearing thresholds who had trouble understanding speech in noise. We used electrocochleography (ECochG) to detect and compare SP/AP amplitude area ratios, a potential indicator of cochlear synaptopathy, and investigate speech perception disorder in noise. Methods: The study included 68 people aged between 18 and 65 years, 35 patients and 33 healthy volunteers, who applied to the otorhinolaryngology clinic between November 2023 and March 2024 with a 2-month history of difficulty understanding speech in noisy environments. Everyone was given a tiptrode electrode ECochG test, and the results were compared between groups. An ECochG test was recorded with tiptrode electrodes and was performed on all participants, and the results were compared between groups. Results: In the ECochG test, the summation potential/action potential (SP/AP) amplitude and area ratios of patients who had difficulty understanding speech in a noisy environment were statistically higher than those of the control group. Conclusion: ECochG testing may provide additional evidence to evaluate auditory nerve pathways.
Are Preoperative CT Findings Useful in Predicting the Duration of Laparoscopic Appendectomy in Pediatric Patients? A Single Center Study
(2024) Taskent, I.; Ece, B.; Narsat, M.A.
Preoperative computed tomography (CT) imaging plays a vital role in accurately diagnosing acute appendicitis and assessing the severity of the condition, as well as the complexity of the surgical procedure. CT imaging provides detailed information on the anatomical and pathological aspects of appendicitis, allowing surgeons to anticipate technical challenges and select the most appropriate surgical approach. This retrospective study aimed to investigate the correlation between preoperative CT findings and the duration of laparoscopic appendectomy (LA) in pediatric patients. This retrospective study included 104 pediatric patients diagnosed with acute appendicitis via contrast-enhanced CT who subsequently underwent laparoscopic appendectomy (LA) between November 2021 and February 2024. CT images were meticulously reviewed by two experienced radiologists blinded to the clinical and surgical outcomes. The severity of appendicitis was evaluated using a five-point scale based on the presence of periappendiceal fat, fluid, extraluminal air, and abscesses. The average operation time was 51.1 ± 21.6 min. Correlation analysis revealed significant positive associations between operation time and neutrophil count ( = 0.014), C-reactive protein levels ( = 0.002), symptom-to-operation time ( = 0.004), and appendix diameter ( = 0.017). The total CT score also showed a significant correlation with operation time ( < 0.001). Multiple regression analysis demonstrated that a symptom duration of more than 2 days ( = 0.047), time from CT to surgery ( = 0.039), and the presence of a periappendiceal abscess ( = 0.005) were independent predictors of prolonged operation time. In the perforated appendicitis group, the presence of a periappendiceal abscess on CT was significantly associated with prolonged operation time ( = 0.020). In the non-perforated group, the presence of periappendiceal fluid was significantly related to longer operation times ( = 0.026). In our study, preoperative CT findings, particularly the presence of a periappendiceal abscess, were significantly associated with prolonged operation times in pediatric patients undergoing laparoscopic appendectomy. Elevated CRP levels, the time between CT imaging and surgery, and a symptom duration of more than 2 days were also found to significantly impact the procedure's duration.
Preliminary Investigation into the Association between Scoliosis and Hypoxia: A Retrospective Cohort Study on the Impact of Eliminating Hypoxic Factors on Scoliosis Outcomes
(2024) Ugur, F.; Topal, K.; Albayrak, M.; Taskin, R.; Topal, M.
Objective: This study delves into the implications of adenoidectomy for scoliosis progression, investigating the intricate nexus of hypoxia, spinal curvature, and surgical intervention. With adenoidectomy being a common procedure for addressing pediatric sleep-disordered breathing, this research study explores its potential impact on spinal health. Patients and methods: Employing a retrospective cohort design, this study gathered data from patients who underwent adenoidectomy, including those with scoliosis, between January 2017 and March 2023. Initial and follow-up evaluations involved clinical and radiological assessments, notably measuring the Cobb angle to quantify spinal curvature. Results: This study enrolled 218 patients under 10 years old. Among them, 18 exhibited Cobb angles of 10° or more, with a mean Cobb angle of 12.8°. In the follow-up evaluation, 83% of patients with initial Cobb angles of 10° or more were reached out to, along with 84.6% of those with Cobb angles below 10°. The postoperative follow-up revealed a notable decrease in Cobb angles for most patients, particularly those with an initial Cobb angle exceeding 10°. Conclusions: This study underscores the potential connection between adenoidectomy, hypoxia, and scoliosis regression, highlighting the importance of early intervention for scoliosis management. Despite certain limitations, this investigation lays the foundation for future research involving larger patient cohorts and multifaceted analyses. The observed interactions between airway function, hypoxia, and spinal health open avenues for refining clinical strategies in scoliosis treatment.
The Effect of Manual Therapy on Psychological Factors and Quality of Life in Lumbar Disc Herniation Patients: A Single Blinded Randomized Clinical Trial
(2024) Taşkaya, B.; Taşkent, İ.; Çakıllı, M.; Yılmaz, Ö.
This study aimed to investigate the effect of manual therapy on pain, kinesiophobia, pain catastrophizing, anxiety, depression, and quality of life in patients with lumbar disc herniation (LDH). The study included 32 LDH patients. Patients were divided into the Manual therapy group (MTG-age 39.81 ± 9.45 years) and the Exercise group (EG-age 38.31 ± 9.21 years) by sealed envelope randomization. Patients were evaluated pre-study, post-study, and after a 3-month period using the McGill-Melzack Pain Questionnaire (MMPQ), Hospital Anxiety and Depression Scale (HADS), Tampa Kinesiophobia Scale (TKS), Pain Catastrophizing Scale (PCS) and Nottingham Health Profile (NSP). The exercise group received a total of ten sessions of stabilization exercises and sham spinal mobilization in five weeks, two sessions per week. In addition to the stabilization exercises, mobilization applications including Anterior-Posterior Lumbar Spinal Mobilization, Lumbar Spinal Rotational Mobilization, and Joint Mobilization in Lumbar Flexion Position, were applied to the manual therapy group. It was found that the HADS and TKS values decreased in the MTG group compared to the pre-treatment period ( < 0.05), while there was no difference between these values in the EG group ( > 0.05). There was a statistically significant difference in the MMPQ, PCS, and NHP values after treatment in both the MTG and EG groups ( < 0.05). It was found that manual therapy had positive effects on psychological factors such as pain, kinesiophobia, pain catastrophizing, anxiety, depression, and quality of life in patients with LDH. NCT05804357 (27 March 2023) (retrospectively registered).

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