Pubmed İndeksli Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12597/3195

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Can Kinesiotaping Reduce Pain in Rib Fractures?: A Randomized Prospective Study
(2024) Dal, İ.; Bektaş, Ö.; Kader, S.; Bodur, G.
Introduction: The aim of this study is to investigate the effect of kinesiotaping on pain scores in patients with rib fractures following isolated thoracic trauma. Materials and methods: In this randomized prospective study, patients with isolated thoracic trauma and rib fractures were randomized into kinesiotaping and control groups between January 24, 2024, and October 1, 2024. Patients in the control group received standard analgesic treatment. In the kinesiotaping group, kinesiotaping bands were applied in addition to the standard treatment. Pain scores using the visual analog scale (VAS) were recorded at admission, the 24th hour, the 4th day, and the 7th day, and the results were statistically compared. Results: A total of 118 patients were evaluated. Eighty-four patients did not meet the inclusion criteria. The 34 patients included in the study were randomized into kinesiotaping and control groups. The two groups were demographically homogeneous. On the 4th day, the mean VAS score was significantly lower in the kinesiotaping group (2.7 ± 1.2) compared to the control group (4.1 ± 1.9) (p = 0.037). No statistically significant difference in VAS scores was observed on the other days. Conclusion: In patients with rib fractures, pain scores decreased more rapidly in those treated with analgesics plus kinesiotaping compared to those treated with analgesics alone.
Effect of middle-age plasma therapy on ileum morphology, immune defense (IgA) and cell proliferation (Ki-67) of female aged rats
(2024) Asmaz, E.D.; Teker, H.T.; Sertkaya, Z.T.; Ceylani, T.; Genç, A.İ.
Blood plasma therapy, a new treatment method to eliminate the damage and deterioration caused by aging in many organ systems, has attracted increasing attention. The digestive tract, which cooperates with many different systems, has strong effects on our health. In the present study, the effects of plasma therapy on the ileum of elderly rats were investigated. Wistar rats (n = 7; 12-15 months old) were given pooled plasma collected from middle-age rats (6 months, n =28) (for 30 days, 0.3 ml daily, intravenously into the tail vein). At the end of the experiment, villus height, crypt depth, total mucosal thickness and surface absorption area were evaluated. In addition, the effects of IgA, which plays a role in the digestive system's defense against microorganisms, were examined. Both the cell proliferation intensity and proliferation index were evaluated in crypt cells. An increase was determined in all morphological parameters in the experimental group. Similarly, plasma application decreased IgA expression and numbers in the experimental groups. Contrarily, cell proliferation parameters showed a significant increase in the experimental groups' crypt cells. Therefore, we found that the treatment supports the digestive system in terms of both nutrient utilization and absorption-related parameters and has a protective effect on intestinal immune system parameters.
Comparative evaluation of 2D and 3D YouTube videos as supplementary educational resources for vitreoretinal surgery training
(2024) Yozgat, Z.; Sahin, H.K.; Dumlupinar, G.İ.; Sabaner, M.C.
Ophthalmologists and ophthalmology residents (ORs) are increasingly turning to the internet for medical information, underscoring the significant role that YouTube videos, particularly three-dimensional (3D) ones, play in lifelong learning. This study aimed to compare the content and quality of 3D YouTube videos with two-dimensional (2D) videos as supplementary educational tools for vitreoretinal surgery. Data collected included video length (minutes), time elapsed since upload (days), number of views, likes, dislikes, vitreoretinal surgery type, and visualization system. Video popularity and interaction were calculated using the video power index, interaction index, and viewing rate. Two senior ophthalmologists (SOs) and 2 ORs evaluated the videos using the DISCERN, Global Quality Score, and usefulness scoring systems. Inter-rater reliability was assessed using the intra-class correlation coefficient. A total of 392 videos were screened, with 67 2D and 67 3D videos deemed appropriate for inclusion. While 2D videos had significantly more views, likes, interaction index, and viewing rate than 3D videos (P < .001 for all), 3D videos were rated higher by ORs across all scoring systems (P < .05 for all). Inter-rater reliability was confirmed to be good, with the lowest intra-class correlation coefficient being 0.796 for SOs (95% confidence interval: 0.668-0.875) and 0.814 for ORs (95% confidence interval: 0.698-0.886). In conclusion, side-by-side 3D YouTube videos offer a valuable supplementary educational tool, enhancing depth perception and enabling both SOs and ORs to better understand the complexities of ocular surgeries, particularly vitreoretinal procedures. These videos can also be used to observe new procedures and refresh previously acquired knowledge of past surgeries.
Immunological Responses, Expression of Immune-Related Genes, and Disease Resistance of Rainbow Trout (Oncorhynchus mykiss) Fed Diets Supplied with Capsicum (Capsicum annuum) Oleoresin
(2024) Yilmaz, S.; Kenanoğlu, O.N.; Ergün, S.; Çelik, E.Ş.; Gürkan, M.; Mehana, E.E.; Abdel-Latif, H.M R
A 45-day feeding study was carried out to assess the immune-stimulatory effects of capsicum oleoresin when added to rainbow trout diets. A total of 450 fish (mean weight: 155.20 ± 1.96 g) were distributed into 400 L tanks (30 fish/tank) across five experimental groups: control (CT, 0%), C7 (0.7%), C14 (1.4%), C21 (2.1%), and C28 (2.8%). Each group consisted of three replicate tanks. At the end of this period, hemato-biochemical parameters, innate immune responses, and immune-related gene expression levels were evaluated, and a histological examination of head kidney and liver sections was conducted. Finally, fish in all groups were challenged with and observed for an additional 20 days. The results revealed that oleoresin supplementation enhanced the immune responses of the treated fish, which was evidenced by the increased globulin, total protein, respiratory burst activity, and total immunoglobulin levels. The highest expression levels of the , , , and genes was noticed in the C7 group, as compared with the results for the other groups. The gene expression levels were higher in all experimental groups than in the CT group, and this increase was at the highest level in the C28 group. Following the bacterial challenge, all experimental groups displayed higher survival rates compared to that of the CT group. These values were 75.93, 72.22, 46.30, 33.33, and 29.63% in the C7, C14, C21, C28, and CT groups, respectively, with the C7 group displaying the highest survival rate among the groups. The histological examination of liver and head kidney tissues revealed that higher doses (in the C21 and C28 groups) showed an increase in cytoplasmic vacuolization, which causes adverse effects on fish health. However, the C7 group displayed normal histological structure in both tissues. Taken together, the most favorable immune responses were achieved in the C7 group, suggesting that 0.7% oleoresin could be applied to rainbow trout to boost immunity and protect the fish from diseases.
Enhancing accuracy and efficiency in upper extremity disability assessments: development and testing of a desktop application
(2024) Ozmen, E.; Güleç, G.G.; İzol Özmen, H.; Civan, M.; Circi, E.; Yuksel, S.; Baris, A.
This study aimed to validate a software application (app) developed by the authors to streamline and enhance the accuracy of disability assessments, specifically for musculoskeletal system disabilities in the upper extremities. A software was developed under a TÜBİTAK-funded project to aid in the disability assessment process. This tool, designed for Windows operating systems and developed in Visual Basic (VB.NET), was tested using archive data from 50 patients, focusing on upper extremity physical evaluations. Statistical analysis, including the Shapiro-Wilk and Independent t-test/Mann-Whitney U-tests, was conducted using IBM SPSS Statistics to compare the app-assisted and manual assessment methods regarding time and rating'. Significant time-saving was observed with the app-assisted method, which was 328.3 seconds faster on average than the manual method. The average rating difference between the 2 methods was minor (0.40 points, 0.92% difference) and not statistically significant (P=.931). The app-assisted method showed efficiency in disability assessment with comparable accuracy to the manual methods. This application was developed for physicians who examine patients with musculoskeletal system disabilities in the upper extremities for the Health Board. Our results show that the application reduces the average evaluation time by 5 minutes while maintaining accuracy comparable to the manual method. It could be a helpful tool for physicians in a clinical setting. Level IV, Diagnostic Study.
Palynological Study of Some Astragalus L. Sections Distributed in Türkiye
(2024) Bilgi, H.; Çeter, T.; Bani, B.; Karabicak, S.; Biyiklioğlu, O.; Özkutlu, İ.; Elfogohi, L.
In this study, the morphological properties of pollen of 14 species from 9 different sections of the genus Astragalus L. (Fabaceae) distributed in Türkiye were examined, identified, and compared under light microscope (LM) and scanning electron microscope (SEM). Pollen grains of the studied taxa are radially symmetrical and isopolar. Pollen shapes were determined as prolate, subprolate, spheroidal, and prolate-spheroidal. The polar axis lengths of the pollen grains were determined to be between 24.5 and 34.4 μm, and the equatorial axis lengths were determined to be between 22.4 and 27.5 μm. The aperture type of pollen grains is mainly trizonacolporate, rarely trisyncolporate. Colpus are thin and long with acute ends. The shapes of the pores were determined as oblate, suboblate, or oblate-spheroidal. Colpus lengths were found to be between 18.2 and 28.8 μm, and widths were found to be between 2.7 and 7.1 μm. In the studied species, four types of ornamentation were determined according to the differences in the polar region and equatorial region. Type 1: perforate in polar and equatorial regions; Type 2: perforate in polar region, microreticulate in equatorial region; Type 3: microreticulate in polar and equatorial regions; Type 4: psilate-perforate in polar region, microreticulate in equatorial region. Principal component analysis (PCA) and unweighted pair group method using arithmetic average (UPGMA) analyses showed that morphological characters of pollen grains were effective in distinguishing species but could not contribute significantly to a distinction according to sections. Pollen size, colpus characteristics, and ornamentation were determined to be important characteristics that distinguish the studied taxa. This study contributes to Astragalus taxonomy and different sub-branches of palynology.
TOTAL OXIDANT AND ANTIOXIDANT LEVELS IN PATIENTS WITH GALLBLADDER STONES OR RELATED COMPLICATIONS: ARE THEY IMPORTANT FOR TREATMENT?
(2024) Çelik, M.E.; Soylu, V.G.; Yilmaz, A.
Background: Many free radicals result in an inflammatory process due to complications caused by gallstones. These free radicals are inactivated by various reactions and participate in different reactions. Molecules are oxidants and antioxidants that take an active role in almost every event that takes place in the body. Aims: To analyse the changes in total antioxidant level (TAL) and total oxidant level (TOL) in the follow-up of patients hospitalized for cholelithiasis or its complications, showing the active oxidative stress, and to test the usability of these parameters in the evaluation of treatment success. Methods: Forty-five patients took part in the study. Blood samples were taken twice, previous to surgery and 6 hours after surgery. Tissue samples were also obtained from patients who were operated. Then, the samples were sent to a laboratory to measure the total oxidant and antioxidant status of patients. Results: The median for the TAL_before (pre-operation or hospitalization in non-operational) variable was 2.40 (interquartile range - IQR=0.50), and the median for the TAL_after variable was 2.20 (IQR=0.33). The median of the tissue-derived TAL variable was 0.32 (IQR=0.13), and the median of the TOL variable was 0.43 (IQR=0.52). The median value of the TAL_before variable for men was 2.50 (IQR=0.50), while the median value for the TAL_before variable for women was 2.30 (IQR=0.50). TAL_before variable values did not show a statistically significant difference according to gender (Z=1.446; p=0.154, p>0.05). Similarly, the median values of TOL_before variable by gender were similar (Z=0.614; p=0.545, p>0.05). Conclusions: Cholelithiasis and its complications cause many inflammatory responses, ending with free radical formation. During follow-up, its level decreases due to consumption or success of the treatment.
Exposure to a 0.9-GHz electromagnetic field on postnatal days 21-45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study
(2024) Keleş, A.İ.; Kaya, H.; Keleş, G.; Erol, H.S.; Mercantepe, T.; Odaci, E.
The aim of this study was to examine the relationship between the renin-angiotensin system (RAS) and histological and biochemical changes occurring in the kidney tissue of male rats exposed to a 0.9 GHz electromagnetic field (EMF). Twelve male rats aged 21 days were randomly assigned to control (C-Gr) and EMF (EMF-Gr) groups. No procedure was performed on C-Gr, while the EMF-Gr rats were exposed to a 0.9 GHz EMF on postnatal days 21-45 (one hour a day for 25 days). Tissues were removed at the end of the experiment and evaluated using biochemical, and histopathological methods. Increased kidney tissue volume and weight and total body weight were determined in the group exposed to EMF. Lipid peroxidation, glutathione, catalase, and superoxide dismutase also increased in the kidney tissue of the EMF-Gr rats. Histopathological evaluation revealed cortical/medullary bleeding/obstruction and widespread fibrosis, dilatation, vacuolization, and degeneration in distal and proximal tubules, decreased and atypical parietal cells, and degeneration in epithelial cells. Additionally, dilated and degenerated glomeruli in the Malpighian body, Bowman's membrane degeneration and degeneration in the vascular pole, podocyte, pedicel and mesangial cells were also observed. As a result of exposure to EMF, oxidative stress, tissue volume and weight increased, and histopathological changes caused the formation of a pathway that triggers RAS in kidney tissues. In conclusion, long-term exposure to 0.9 GHz EMF can activate the renin-angiotensin system in the rat kidney, and we think that such activation may be associated with structural, histopathological, and biochemical changes occurring in renal tissue.
The Effects of a Smartphone App-Supported Nursing Care Program on the Disease Self-Management of Hypertensive Patients: A Randomized Controlled Study
(2024) Arabaci, Z.; Toraman, A.U.
Aim: Hypertension is one of the most common chronic diseases worldwide. Therefore, it is essential to improve patients' adherence to treatment in order to control their blood pressure. The present study aims to examine the effect of a smartphone application-supported nursing care program provided by a nurse on medication adherence and achievement of normal systolic and diastolic blood pressure levels among patients diagnosed with primary hypertension and registered at the Family Health Center within the context of patients' self-management behaviors. Methods: A randomized controlled experimental study design. CONSORT flow chart was used in the study. The study sample consisted of 41 hypertensive patients in the intervention group and 41 hypertensive patients in the control group. The intervention group was supported with a smartphone application named "HiperDostum" based on the health belief model, whereas the control group continued to receive standard healthcare services provided by the Family Health Center, to which they were affiliated. Data were collected using the "Patient Information Form," "Blood Pressure Monitoring Form," and the "Medication Adherence Self-Efficacy Scale-Short Form." Results: It was observed that the intervention group participants had higher medication adherence self-efficacy scale scores when compared to the control group participants. Comparing the blood pressure values by group, time, and group*time interaction, it was determined that there were statistically significant differences in systolic blood pressure values by time and group*time interaction. Conclusion: Considering the widespread use of smartphones and smartphone application-supported nursing care can be successfully used to enhance self-management and improve treatment adherence among hypertensive patients in primary healthcare institutions. Trial registration: Registration number: NCT0532140; NAME OF TRIAL REGISTRY: The Effect of Smart Phone Application Supported Nursing Care Program on the Self-Management of Hypertensive Patients.
Evaluation of the Antimicrobial Effects of Olive Mill Wastewater Extract Against Food Spoiling/Poisoning, Fish-Pathogenic and Non-Pathogenic Microorganisms
(2024) Yılmaz, D.K.; Kesbiç, F.I.; Çelik, E.Ş.; Odabaşı, D.A.; Yilmaz, S.; Abdel-Latif, H. M R
Although antibiotics are the main therapy for bacterial infections, the reports showed that the overuse (or misuse) of antibiotics will results in several problems such as the development of antibiotic-resistant strains, persistence of drug residues, and numerous environmental concerns. Therefore, finding antibiotic alternatives is considered of vital importance. Investigation of the antimicrobial properties of several plant substances and extracts is of great value to replace antibiotics. With this objective, this study aimed to evaluate the antimicrobial activities of an ethanolic extract prepared from olive mill wastewater (OMWW), which is a by-product of olive oil production with considerable environmental burden, against 38 bacterial strains, including fish-associated pathogens, non-pathogenic isolates, collection strains, and one yeast strain, . Disk diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal/fungicidal concentration (MBC/MFC) tests were used to determine the antimicrobial activity of the OMWWE. According to the results, OMWWE provoked strong inhibitory effects against strain SY-S145. It also showed a moderate inhibitory effect on strain SY-PS16 and strain SY-L24. The MIC and MBC of OMWWE on SY-S145, strain C24, and strain SY-L24 were 500 µg/mL. The MIC and MBC on ATCC 17802 were 1000 µg/mL, whereas the values for ATCC 33658 were 500 µg/mL and 1000 µg/mL, respectively. To put it briefly, the OMWW extract showed high antimicrobial activity and can act as an environmentally friendly additive for the control and prevention of diseases caused by , , , , , and Its active agents also prevented infections of both fish-associated pathogens and food spoiling bacteria, which means it can not only help in the disease control mechanism but also in improving the safety of food by reduction of the microbial contamination.
Hair and Blood Trace Elements (Cadmium, Zinc, Chrome, Lead, Iron and Copper) Biomonitoring in the Athletic Horse: The Potential Role of Haematological Parameters as Biomarkers
(2024) Aragona, F.; Giannetto, C.; Piccione, G.; Licata, P.; Deniz, Ö.; Fazio, F.
The aim of the present study was the evaluation of the bioaccumulation of cadmium (Cd), Zinc (Zn), Chrome (Cr), Lead (Pb), Iron (Fe) and Copper (Cu), in the blood, serum, tail and mane of horses from the industrialized area of Milazzo (Messina, Sicily), to understand the relationships between haematological parameters: Red Blood Cells (RBCs), White Blood Cells (WBCs), Haemoglobin (Hb), Haematocrit (Hct), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), Platelets (PLTs) and the concentrations of trace elements. Blood and hair samples from 20 healthy Italian Saddle horses and water, hay and concentrates samples were obtained to determine the haemogram and mineral concentration using a Thermo Scientific iCAP-Q ICP-MS spectrometer. Descriptive analysis showed a higher concentration of Zn, Cr, Pb, Fe, and Cu in the blood and a higher concentration of Cd in the tail than other substrates. A positive correlation was found for Cr ( < 0.0001) and Zn ( < 0.01) between blood and serum substrates, for Zn ( < 0.001) between mane and tail and for Pb ( < 0.01) between blood and mane, while a negative correlation was observed for Cr ( < 0.01) between blood and tail. Results showed a close relationship between the bioaccumulation of certain trace elements in biological substrates and haematological parameters, which represent useful biomarkers suggesting further studies, given the role of haematological parameters in athletic horses.
Assessment of tibialis anterior tendon insertion variations in relation to hallux valgus utilizing magnetic resonance imaging
(2024) Uğur, F.; Albayrak, M.; Akar, B.; Reis, B.
Background: Hallux valgus is a deformity characterized by lateral deviation of the big toe and medial deviation of the first metatarsal, causing difficulty in walking and requiring various treatments. Despite its multifactorial etiology, the role of the tibialis anterior tendon in hallux valgus and its variations in the morphology of tibialis anterior tendon distal insertion sites have not been fully explored. This study aimed to evaluate the effect of such variations on hallux valgus using magnetic resonance imaging. Methods: This was a retrospective study and included 115 individuals aged 18 years and older who underwent foot radiographs and MRI. The participants were divided into a hallux valgus group of 53 patients and a control group of 62 people based on radiographic measurements. Tibialis anterior tendon distal attachment was classified into five types according to the attachment morphology. Statistical analyses were performed to evaluate the relationship between the tibialis anterior tendon types and hallux valgus severity. Results: Among the participants, patients who underwent foot radiography and MRI due to any medical indication 70.4% were female, with a mean age of 43.83 ± 15.25 years. In terms of tibialis anterior tendon distal attachment, the most common type was Type 5 (40.9%), followed by Type 2 (34.8%). Type 4 was not observed in any case. In all participants, the mean hallux valgus angle was 20.63 ± 8.42o, and the mean intermetatarsal angle was 9.69 ± 2.68o. Tibialis anterior tendon distal attachment Type 5 was significantly associated with an increased hallux valgus angle but not with the intermetatarsal angle. We found a significant relationship between the diameter of the tibialis anterior tendon and hallux valgus angle. Conclusions: This study revealed a significant association between hallux valgus and Type 5 tibialis anterior tendon distal attachment, suggesting that tibialis anterior tendon morphology influences hallux valgus severity. The findings underscore the importance of considering variations in tibialis anterior tendon distal attachment sites in the etiopathogenesis and treatment planning of hallux valgus.
Efficacy of Low-Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats
(2024) Yılmaz, G.B.; Saraçoğlu, K.T.; Aykın, U.; Akça, M.; Demirtaş, C.; Saraçoğlu, A.; Yıldırım, M.
Refractory status epilepticus (RSE) is a condition with serious mortality and morbidity rate, resistant to benzodiazepine and second-line antiepileptic drugs. This study aimed to electrophysiologically investigate the combination of NMDA receptor antagonist ketamine and GABAergic agent propofol in an RSE model induced by lithium-pilocarpine in male Sprague-Dawley rats. Seventy-two male Sprague-Dawley rats were divided into nine groups. The RSE model was induced by subcutaneous injection of lithium-CI (5 mEq/kg) and intraperitoneal injection of pilocarpine-HCl (320 mg/kg), after implanting tripolar EEG electrode. Ketamine (30, 60, and 90 mg/kg), propofol (20, 40, and 80 mg/kg), and combinations of both drugs (15 + 20 and 30 + 40 mg/kg) were administered intraperitoneally to animals with RSE. Video-EEG recordings were taken after inducing model and 48 h later. The efficacy of drugs was statistically evaluated based on spike frequencies (spikes/min) and amplitudes (mV). Compared to RSE group, it was determined that 30 and 60 mg/kg doses of ketamine provided effective seizure control and prevented mortality (p < 0.001), while the 90 mg/kg showed toxic effects in all animals and caused mortality. The 80 mg/kg dose of propofol provided seizure control and reduced the mortality rate to 16.7% (p < 0.001), whereas the 20 mg/kg resulted in a 100% mortality rate. The low-dose ketamine+propofol (15 + 20 mg/kg) combination provided early onset seizure control and were as effective as 80 mg/kg propofol (p < 0.05). The study concluded that in the experimental RSE model, seizure control could be achieved with low-dose combination of ketamine and propofol without the need for high doses as in monotherapy, thus preventing dose-related adverse effects.
One-Year Outcomes of Aflibercept in Treat-and-Extend Versus Pro Re Nata Regimens for Bevacizumab-Resistant Diabetic Macular Edema: A Real-World Study
(2024) Yozgat, Z.; Isik, M.U.; Sabaner, M.C.
Introduction: The aim of this study was to compare the efficacy of the treat-and-extend (TAE) regimen versus the pro re nata (PRN) regimen in patients with bevacizumab-resistant diabetic macular edema (DME) treated with aflibercept, with or without adjunctive laser therapy. Methods: Ninety-one eyes from 91 patients who were switched to aflibercept after three consecutive intravitreal bevacizumab injections for the treatment of DME were included in this retrospective real-world study. The patients were categorized into three groups: TAE (n = 30), TAE + laser (n = 31), and PRN (n = 30). Changes in best-corrected visual acuity and central macular subfield thickness (CMST) at 12, 24, and 52 weeks were defined as the primary functional and anatomical outcomes. Results: A total of 91 eyes from 91 patients (49.5% female) with a mean age of 63.9 ± 7.1 years were included in the analysis. At 52 weeks, the mean letter gains were 8.03, 8.90, and 10.23 in the TAE, TAE + laser, and PRN groups, respectively. Anatomical improvements, as measured by CMST reduction, were 55.33 µm, 33.35 µm, and 48.96 µm in the TAE, TAE + laser, and PRN groups, respectively. The average number of injections administered was 7.7, 8.1, and 8.1, respectively. The final extension interval for the TAE group was 8.7 weeks, compared to 9.5 weeks in the TAE + laser group. Conclusions: The PRN group demonstrated the highest functional improvement while the TAE group showed the greatest anatomical improvement. Overall, both anatomical and functional outcomes in the TAE regimen were comparable to the PRN regimen in patients with bevacizumab-resistant diabetic macular edema.
Which Canal BPPV Should be Checked for Residual Disease after 1 Week?
(2024) Öner, F.
The study aimed to determine the residual disease rate due to the affected canal in patients diagnosed with benign paroxysmal positional vertigo (BPPV) and reveal the factors affecting the residual disease. A comprehensive investigation was conducted to determine the effect of the affected canal, sociodemographic data, body mass index, hospital admission time, systemic disease history, betahistine use, and previous otologic vertigo history on the residual BPPV rate. This investigation was carried out on 201 patients who underwent repositioning maneuvers with BPPV diagnosis and came for a follow-up 1 week later, ensuring a robust and reliable dataset. Two hundred one patients were included in the study: 91 (45.3%) male and 110 (54.7%) female. The mean age of the patients was 60.44 + 13.83 (min = 23-max = 90) years. Residual disease was significantly higher in bilateral canal involvement ( = .001), anterior canal involvement, and those presenting 72 hours after the onset of the vertigo attack ( = .001). There was no significant difference between residual disease and those with successful initial maneuver results regarding age, gender, obesity, canalolithiasis, or cupulolithiasis. The most effective treatment for BPPV is canalith reposition maneuvers. We recommend that patients be called for follow-up after 1 week, especially in cases of anterior canal involvement and bilateral involvement. These findings provide valuable insights for the management of BPPV.
Dietary Effect of Withania somnifera Root Powder on Growth, Hematobiochemical Parameters, Immunity, and Disease Resistance to Aeromonas hydrophila in Cyprinus carpio
(2024) Habib, S.S.; Saeed, M.Q.; Masud, S.; Kesbiç, O. S.; Ujan, J.A.; Cravana, C.; Al-Rejaie, S. S; Mohany, M.; Fazio, F.
This study investigates the influence of root powder (WSRP) on different aspects of common carp (), including growth, hematobiochemical parameters, antioxidant status, nonspecific immune response, and resilience to bacterial infections. Over a 60-day period, 180 common carp fingerlings (11.73 ± 0.52 g) were subjected to diets supplemented with increasing WSRP levels (0 (control), 1% (WSRP1), 2.5% (WSRP2.5), and 4% (WSRP4)). Nonspecific immune parameters were evaluated using serum samples collected at intervals of 0, 20, 40, and 60 days. After the feeding trial, the fish underwent experimental challenge with , and relative percentage survival (RPS) was monitored for 14 days. The findings revealed a considerable ( < 0.05) enhancement in growth performance and a decreased feed conversion ratio (FCR) with increasing WSRP supplementation. Additionally, hematological and biochemical profiles exhibited improvements in groups receiving WSRP-enriched diets. Fish serum antioxidant status showed a significant ( < 0.05) increase, as indicated by increased activities of total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in WSRP4. WSRP-supplemented diets led to remarkable enhancements in lysozyme activity ( = 0.001), phagocytic activity ( = 0.002), and RPS ( = 0.003), peaking in WSRP4 at day 60. Furthermore, WSRP2.5 and WSRP4 demonstrated a substantial decrease ( > 0.05) in serum glucose and cortisol levels compared to other groups. In conclusion, WSRP proves valuable for enhancing growth, blood parameters, antioxidant balance, immune response, and infection resistance in common carp, especially at 2.5%-4% dietary supplementation levels. In the future, it will be crucial to study the long-term effects of WSRP supplementation on fish health, as well as its potential for large-scale aquaculture and economic viability in the aquafeed industry.
Nettle (Urtica dioica) supplementation: impact on growth, hematology, immune response, and resilience to Aeromonas hydrophila in Labeo rohita fingerlings
(2024) Ujan, J. A.; Raza, A.; Habib, S. S.; Athar, R.; Kesbiç, O. S.; Batool, A. I.; Habib, S. F.; Mohany, M.; Fazio, F.
The significance of plant-derived products in aquaculture lies in their potential to offer sustainable alternatives, promoting eco-friendly practices. This study investigated the impact of nettle (Urtica dioica) leaves powder on the growth efficiency, hemato-biochemical variables and non-specific immune system of rohu, Labeo rohita fingerlings. To achieve this objective, sample average weight (5.23 ± 0.34 g) were categorized into four groups, namely control, T1, T2 and T3 in triplicate and administered diets fortified with nettle in amounts of 0, 1, 3 and 5% respectively for a duration of 60 days. After 60 days of fortified diet, the fish underwent intraperitoneal injection with bacteria (Aeromonas hydrophila), and subsequent relative percentage survival (RPS) was observed. The growth performance, including "weight gain (WG), specific growth rate (SGR), feed conversion ratio (FCR) and feed efficiency ratio (FER)", were notably higher in the T3 group (5%) than in others. The hematological values of White blood cell, hematocrit, and hemoglobin revealed higher levels with a fortified diet. The dietary supplementation of nettle reduced serum cholesterol and glucose concentration, whereas it increased albumin, globulin, and total protein in the fish blood. Enhancements in lysozyme and myeloperoxidase activity were observed in the intervention groups with feed containing nettle supplementation. The nettle diet at a 5% concentration demonstrated a higher RPS than the others following injection with A. hydrophila. The findings indicate the potential of nettle as a valuable nutritional supplement for increasing fish immunological reaction and bolstering pathogen resistance.
Efficacy of intravitreal faricimab therapy for polypoidal choroidal vasculopathy: A systematic review and meta-analysis
(2024) Arnold-Vangsted, A.; Schou, M. G; Balaratnasingam, C.; Cehofski, L.J; Chhablani, J.; van Dijk, E. H C; Eriksen, N. S; Grauslund, J.; Hajari, J.N; Sabaner, M C.; Schneider, M.; Subhi, Y.
Polypoidal choroidal vasculopathy (PCV) is an aneurismal type of macular neovascularization that show similarities with age-related macular degeneration and diseases that are part of the pachychoroid disease spectrum. Exudative changes in PCV can be treated with intravitreal anti-vascular endothelial growth factor monotherapy; however, a combination therapy with photodynamic therapy may be required. In this systematic review and meta-analysis, we evaluated the efficacy of faricimab for PCV. We searched 12 literature databases for eligible studies. All study evaluation and data extraction were made by two authors in duplicate. Studies eligible for analysis were included for a qualitative and quantitative review. We identified seven studies with data from 150 eyes with PCV, five studies were of treatment-naïve eyes who were commenced in faricimab monotherapy, and two studies were of switch-over to faricimab from other anti-VEGF drugs. After faricimab loading dose in treatment-naïve eyes, the best-corrected visual acuity (BCVA) remained stable at -0.09 (95% CI: -0.20-0.03) logMAR, central retinal thickness (CRT) decreased -169 (95% CI: -311--27) μm, and 48.7 (95% CI: 32.5-65.0) % of eyes obtained polyp closure. In switch-over eyes, 57%-67% experienced fluid reduction and 21% were able to extend their treatment interval. In conclusion, faricimab monotherapy for PCV leads to acceptable clinical outcomes in terms of stable BCVA, reduction of CRT, and high incidence of polyp closure. Some cases may benefit from a switch to faricimab. However, long-term efficacy studies and controlled comparative studies are warranted.
Environmental effects of acid mine drainage and rehabilitation options at closed mine site: a case study
(2024) Konanç, M.U.; Değermenci, G.D.
Irregular waste storage at closed mine sites poses severe environmental problems. This study evaluates the concentrations and effects of trace elements released into the environment by mining activity by analyzing soil, water, and sediment samples taken from a copper mining site. According to the data, acidic mine drainage was the main cause of the high concentrations of trace elements in the soil and sediments, including arsenic (As), cadmium (Cd), lead (Pb), and copper (Cu). The concentrations of As, Cd, Pb, and Cu in soil and sediments were 2734-times, 1189-times, 157-times and 32 times higher, respectively, in comparison to the background values of averaged concentrations of these elements in the upper crust. Geological and statistical studies indicate that the primary constituents of these pollutants are chalcopyrite and pyrite derivatives present in the primary rock structure. Using water analysis data from 2011 to 2020, the release of essential trace element into water was investigated to monitor the environmental effects of acidic mine drainage (AMD) from the closed Kuvarshan copper mine in the Artvin region of Turkey. This study demonstrates that trace elements concentrations may change according to local and seasonal factors and highlights the importance of conducting routine environmental monitoring studies.
Preliminary Study on the Impact of 900MHz Radiation on Human Sperm: An In Vitro Molecular Approach
(2024) Keskin, I.; Karabulut, S.; Kaplan, A.A.; Alagöz, M.; Akdeniz, M.; Tüfekci, K.K.; Davis, D.L.; Kaplan, S.
The use of technologies that produce and emit electromagnetic fields (EMF) is growing exponentially worldwide. The biological effects of EMF-emitting equipment, such as mobile phones and other wireless devices, have been studied in the last decade using in vitro and in vivo methods. Infertility is a growing health problem, and nearly half of cases are because of male-factor. This study investigated the direct in vitro effects of 900MHz radiation exposure on sperm parameters, genetic status, apoptotic markers, and the PI3K/AKT signaling pathway in healthy normozoospermic men. Semen samples were divided into four groups, two control (30min and 1h) and two EMF exposure (30min and 1h). Sperm parameters (motility, progressive motility, acrosomal index, morphology), genetic status (DNA fragmentation and chromatin integrity), apoptotic markers (cytokine-c and caspase-3 expression) and the PI3K/AKT signaling pathway (phosphoinoitide 3-kinase-PI3K- and phosphorylated AKT- p-AKT-) were analysed. Sperm motility were significantly reduced in 30min EMF exposure while a significant increase in the expression of p-AKT were observed in 1h EMF exposure group. An increased vacuolisation, acrosomal defect, extension of subacrosomal space, uncondensed chromatin structure, apoptotic signs and disrupted axoneme were observed in both EMF groups which were not observed in the control group. Other sperm parameters (morphology and acrosomal index), genetic status, apoptotic markers and the PI3K expression rates had no significant change.

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