Effect of White Mulberry Extract on Performance, Anti-inflammatory and Serum Antioxidant Parameters in Diabetes-induced Rats with Streptozotocin

Abstract

This study was conducted to investigate the effect of the white mulberry extract on histopathology, anti-inflammatoryproperties of liver tissue, blood serum antioxidant parameters and performance parameters of diabetes-induced rats withstreptozotocin. Experimental groups consist of 24 animals which were divided into four groups; control group (C, n: 5),streptozotocin applied group 1 (DG 1, n: 6), mulberry extract applied group 2 (DG 2, n: 7), streptozotocin and mulberryextract experimental group 3 (DG 3, n:6), totally 24 animals were used. Although vascular congestion in the liver tissue wasdetected 2 animals in C and DG 2 groups and 1 animal in DG 3 group, vascular congestion was detected in all animals inDG 1 group. (P <0.05). Inflammatory findings of liver tissue were not seen in C, whereas it was mild in 2 animals in DG 2and it was seen in all animals in the group of DG 1. Degeneration findings in liver tissue were not seen in C, but it wasdetected in 1 animal of DG 2 and all animals in DG 1 (P <0.01). There was no statistical difference between theceruloplasmin levels of the groups (P> 0.05). Live weight gain in control group 150,03 g., DG 2 114.43 g. (P <0,01). 1.33 g.live weight gain and weight loss in DG 3 (P> 0.05). In conclusion, mulberry extract applied to rats significantly reducedvascular congestion, inflammation and degeneration findings in liver tissue and it can be said that mulberry extract hasantiinflammatory effect.