Publication: Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
dc.contributor.author | Corum D.D., Corum O., Altan F., Eser Faki H., Bahcivan E., Er A., Uney K. | |
dc.contributor.author | Corum, DD, Corum, O, Altan, F, Faki, HE, Bahcivan, E, Er, A, Uney, K | |
dc.date.accessioned | 2023-05-09T16:15:08Z | |
dc.date.available | 2023-05-09T16:15:08Z | |
dc.date.issued | 2018-12-01 | |
dc.date.issued | 2018.01.01 | |
dc.description.abstract | The objective of this study was to evaluate the pharmacokinetics of CTX following intravenous administration of ascending doses in sheep. In this study, six clinically healthy Akkaraman sheep (2.4 ± 0.4 years and 50 ± 3 kg of body weight) were used. CTX was administered intravenously to each sheep at 20, 40, and 80 mg/kg doses in a crossover design with a 15-day washout period. Plasma concentrations of CTX were measured using the high-performance liquid chromatography-UV method. Pharmacokinetic parameters were calculated by non-compartmental analysis. CTX was well tolerated following administration at 20, 40, and 80 mg/kg doses. The elimination half-life following administration of 40 and 80 mg/kg doses were significantly longer than that of 20 mg/kg dose (P < 0.05). The volume of distribution at steady state was similar among the groups (P > 0.05). When compared to 20 mg/kg, dose-normalized AUC0–∞ at the 80 mg/kg dose significantly increased (P < 0.05). The relation between dose and AUC0–∞ was linear. Our study showed that CTX can be used at 12-h intervals for 20, 40, and 80 mg/kg doses to maintain T > minimum inhibitory concentration (MIC) of >40% for the treatment of infections caused by bacteria with MIC values ≤2, ≤4, and ≤16 μg/mL, respectively. This information may be helpful in adjusting the dosage regimen, but there is a need for future work. | |
dc.identifier.doi | 10.1016/j.smallrumres.2018.07.019 | |
dc.identifier.eissn | 1879-0941 | |
dc.identifier.endpage | 112 | |
dc.identifier.issn | 0921-4488 | |
dc.identifier.scopus | 2-s2.0-85050946317 | |
dc.identifier.startpage | 108 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/13079 | |
dc.identifier.volume | 169 | |
dc.identifier.wos | WOS:000454968700018 | |
dc.relation.ispartof | Small Ruminant Research | |
dc.relation.ispartof | SMALL RUMINANT RESEARCH | |
dc.rights | false | |
dc.subject | Ascending dose | Ceftriaxone | Pharmacokinetics | Sheep | |
dc.title | Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep | |
dc.title | Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep | |
dc.type | Article | |
dspace.entity.type | Publication | |
oaire.citation.volume | 169 | |
relation.isScopusOfPublication | 11c0fedd-2e9e-4b76-8693-ad44f08c61c8 | |
relation.isScopusOfPublication.latestForDiscovery | 11c0fedd-2e9e-4b76-8693-ad44f08c61c8 | |
relation.isWosOfPublication | ae81e0c4-d643-47c0-b859-ac1f3099be84 | |
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