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The effect of N-acetylcysteine use against ER stress in kidney tissue of obese rats

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dc.contributor.authorTATAR, Musa
dc.date.accessioned2026-01-04T19:08:00Z
dc.date.issued2023-08-30
dc.description.abstractEndoplasmic reticulum (ER) stress has recently gained increasing importance in the pathogenesis of obesity-associated kidney disease. N-acetylcysteine (NAC) is an antioxidant that acts directly and indirectly through upregulating cellular antioxidants. This study's obesity model was created using a high-fat (60% k/cal) diet. NAC (150 mg/kg) was administered by intragastric gavage for eight weeks in both the NAC and obesity + NAC (ObNAC) groups. GRP78 and PERK expressions were determined immunohistochemically in sections taken from kidney tissues obtained at the end of the experiment. The H score of GRP78 was significantly higher in the Ob group than in the Cont, NAC, and ObNAC groups (p 0.05). The PERK H score of the Ob group was also significantly higher than the Cont, NAC, and ObNAC groups (p
dc.description.urihttps://doi.org/10.30607/kvj.1312847
dc.identifier.doi10.30607/kvj.1312847
dc.identifier.issn1308-1594
dc.identifier.openairedoi_________::dbeaf15205602edda0e66ce11afcb198
dc.identifier.orcid0000-0002-5707-8832
dc.identifier.urihttps://hdl.handle.net/20.500.12597/40990
dc.language.isoeng
dc.publisherKocatepe Veteriner Dergisi
dc.relation.ispartofKocatepe Veterinary Journal
dc.rightsOPEN
dc.subject.sdg2. Zero hunger
dc.titleThe effect of N-acetylcysteine use against ER stress in kidney tissue of obese rats
dc.typeArticle
dspace.entity.typePublication
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