Publication: Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent.
dc.contributor.author | Aygun, Aysenur, Gülbagca, Fulya, Ozer, Lutfiye Yildiz, Ustaoglu, Buket, Altunoglu, Yasemin Celik, Baloglu, Mehmet Cengiz, Atalar, Mehmet Nuri, Alma, Mehmet Hakkı, Sen, Fatih | |
dc.contributor.author | Aygun, A, Gulbagca, F, Ozer, LY, Ustaoglu, B, Altunoglu, YC, Baloglu, MC, Atalar, MN, Alma, MH, Sen, F | |
dc.date.accessioned | 2023-05-09T16:06:55Z | |
dc.date.available | 2023-05-09T16:06:55Z | |
dc.date.issued | 2020-02-05T00:00:00Z | |
dc.date.issued | 2020.01.01 | |
dc.description.abstract | Herein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Transmission Electron Microscopy (TEM), UV-vis spectrophotometer, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). According to TEM analysis, Pt nanoparticles have spherical shapes and sizes between 1-6 nm. Moreover, the biogenic Pt NPs was assessed for its cytotoxicity effect on MDA-MB-231 breast and HeLa cervical cancer lines and their antibacterial effect against selected strains of gram-positive and negative bacteria. The cytotoxicity and bacterial tests showed the effectiveness of biogenic Pt nanoparticles. Dose-dependent toxicity effects were shown in the MDA-MB-231 breast and HeLa cervical cancer lines (IC50: 36.86 μg/mL and 19.83 μg/mL, respectively). In addition, Pt NPs showed high zone diameters against gram-positive and gram-negative bacteria at concentrations of 100 and 500 μg/ml. These results contribute to the development of the pharmaceutical industry as a potential antibacterial and anticancer agent. | |
dc.identifier.doi | 10.1016/j.jpba.2019.112961 | |
dc.identifier.eissn | 1873-264X | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.pubmed | 31732404 | |
dc.identifier.scopus | 2-s2.0-85075540380 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/12939 | |
dc.identifier.volume | 179 | |
dc.identifier.wos | WOS:000508752400022 | |
dc.relation.ispartof | Journal of Pharmaceutical and Biomedical Analysis | |
dc.relation.ispartof | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | |
dc.rights | false | |
dc.subject | Antibacterial | |
dc.title | Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent. | |
dc.title | Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
oaire.citation.volume | 179 | |
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