Publication: Evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives
dc.contributor.author | Ramadan M.A.G., Baloglu M.C., Altunoglu Y.C., Kandemirli F., Burhan H., Aygün A., Sayiner H.S., Ozyigit F., Şen F. | |
dc.contributor.author | Ganim, MA, Baloglu, MC, Altunoglu, YC, Kandemirli, F, Burhan, H, Aygun, A, Sayiner, HS, Ozyigit, F, Sen, F | |
dc.date.accessioned | 2023-05-09T19:43:00Z | |
dc.date.available | 2023-05-09T19:43:00Z | |
dc.date.issued | 2020-06-01 | |
dc.date.issued | 2020.01.01 | |
dc.description.abstract | Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gramnegative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity. | |
dc.identifier.doi | 10.22052/JNS.2020.03.007 | |
dc.identifier.eissn | 2251-788X | |
dc.identifier.endpage | 517 | |
dc.identifier.issn | 2251-7871 | |
dc.identifier.scopus | 2-s2.0-85091853796 | |
dc.identifier.startpage | 509 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/14301 | |
dc.identifier.volume | 10 | |
dc.identifier.wos | WOS:000577165100007 | |
dc.relation.ispartof | Journal of Nanostructures | |
dc.relation.ispartof | JOURNAL OF NANOSTRUCTURES | |
dc.rights | false | |
dc.subject | 5-Fluoro-Isatin | Antimicrobial activity | DNA protection | Thiosemicarbazone | |
dc.title | Evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives | |
dc.title | Evaluation of Biological Activity of 5-Fluoro-Isatin Thiosemicarbazone Derivatives | |
dc.type | Article | |
dspace.entity.type | Publication | |
oaire.citation.issue | 3 | |
oaire.citation.volume | 10 | |
relation.isScopusOfPublication | 36858c9c-a945-47bc-b88b-99fec6037267 | |
relation.isScopusOfPublication.latestForDiscovery | 36858c9c-a945-47bc-b88b-99fec6037267 | |
relation.isWosOfPublication | 2c5fbfc3-41d7-45b6-a70b-1091ef8d607e | |
relation.isWosOfPublication.latestForDiscovery | 2c5fbfc3-41d7-45b6-a70b-1091ef8d607e |