Publication: Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats
dc.contributor.author | Tekeli I.O., Turk E., Durna Corum D., Corum O., Kirgiz F.C., Sakin F., Uney K. | |
dc.contributor.author | Tekeli, IO, Turk, E, Corum, DD, Corum, O, Kirgiz, FC, Sakin, F, Uney, K | |
dc.date.accessioned | 2023-05-09T18:34:19Z | |
dc.date.available | 2023-05-09T18:34:19Z | |
dc.date.issued | 2020-09-01 | |
dc.date.issued | 2020.01.01 | |
dc.description.abstract | The pharmacokinetics of cefquinome (2 mg/kg every 24 hr for 5 days) was determined following intramuscular administration alone and co-administration with ketoprofen (3 mg/kg every 24 hr for 5 days) in goats. Six goats were used for the study. In the study, the crossover pharmacokinetics design with 20-day washout period was performed in two periods. Plasma concentrations of cefquinome were assayed using high-performance liquid chromatography by ultraviolet detection. The mean terminal elimination half-life (t1/2ʎz), area under the concentration–time curve (AUC0–24), peak concentration (Cmax), apparent volume of distribution (Vdarea/F), and total body clearance (CL/F) of cefquinome after the administration alone were 4.85 hr, 11.06 hr*µg/ml, 2.37 µg/mL, 1.23 L/kg, and 0.17 L/h/kg after the first dose, and 5.88 hr, 17.01 hr*µg/mL, 3.04 µg/mL, 0.95 L/kg, and 0.11 L/h/kg after the last dose. Ketoprofen significantly prolonged t1/2ʎz of cefquinome, increased AUC0–24 and Cmax, and decreased Vdarea/F and CL/F. Cefquinome exhibited low accumulation after the administration alone and in combination with ketoprofen. These results indicated that ketoprofen prolonged the elimination of cefquinome in goats. The 24-hr dosing intervals at 2 mg/kg dose of cefquinome, which co-administered with ketoprofen, may maintain T> minimum inhibitory concentration (MIC) values above 40% in the treatment of infections caused by susceptible pathogens with the MIC value of ≤0.75 μg/ml in goats with an inflammatory condition. | |
dc.identifier.doi | 10.1111/jvp.12904 | |
dc.identifier.eissn | 1365-2885 | |
dc.identifier.endpage | 447 | |
dc.identifier.issn | 0140-7783 | |
dc.identifier.scopus | 2-s2.0-85089693109 | |
dc.identifier.startpage | 440 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/13435 | |
dc.identifier.volume | 43 | |
dc.identifier.wos | WOS:000560601300001 | |
dc.relation.ispartof | Journal of Veterinary Pharmacology and Therapeutics | |
dc.relation.ispartof | JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | |
dc.rights | false | |
dc.subject | Cefquinome | goat | ketoprofen | pharmacokinetics | repeated dose | |
dc.title | Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats | |
dc.title | Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats | |
dc.type | Article | |
dspace.entity.type | Publication | |
oaire.citation.issue | 5 | |
oaire.citation.volume | 43 | |
relation.isScopusOfPublication | 3a5136fc-09e2-4ef7-b8fa-e790e9ac3854 | |
relation.isScopusOfPublication.latestForDiscovery | 3a5136fc-09e2-4ef7-b8fa-e790e9ac3854 | |
relation.isWosOfPublication | 0191cdb8-379f-4b53-893e-c0e91283d539 | |
relation.isWosOfPublication.latestForDiscovery | 0191cdb8-379f-4b53-893e-c0e91283d539 |