Publication: Lack of association between serum prolactin and lead exposure among battery workers
dc.contributor.author | Abusoglu S., Tutkun E., Yilmaz O.H., Gunduzoz M., Bacaksiz A., Giynas N., Aydin E.G., Park E.K., Unlu A. | |
dc.contributor.author | Abusoglu, S, Tutkun, E, Yilmaz, OH, Gunduzoz, M, Bacaksiz, A, Giynas, N, Aydin, EG, Park, EK, Unlu, A | |
dc.date.accessioned | 2023-05-09T20:41:08Z | |
dc.date.available | 2023-05-09T20:41:08Z | |
dc.date.issued | 2015-01-01 | |
dc.date.issued | 2015.01.01 | |
dc.description.abstract | Objective: Serum prolactin (S-PRL) has been reported as a biomarker of early neurotoxic effect related to lead exposure. Raised S-PRL levels are generally considered to provide indirect evidence of reduced dopaminergic tuberoinfundibular (TIDA) activity. Elevated serum prolactin levels were reported due to lead-exposure. Our aim was to determine the relation between serum prolactin levels and lead-exposure. Material: Serum and whole blood samples were collected from 72 non-exposed and 35 lead-exposed male workers. Method: Blood lead was analyzed by Inductively Coupled Plasma - Mass Spectrometer. Serum prolactin levels were analyzed by immunological method. Serum alkaline phosphatase (ALP) and whole blood count were analyzed by using commercial kits. Results: Although serum prolactin levels were higher in control group compared to lead-exposed group (12.7 ± 7.5 vs. 11.8 ± 77), this difference was not statistically significant (p = 0.432). Mean corpuscular hemoglobin concentration (MCHC) was significantly higher in control group than lead-exposed group (p < 0.001) and reticulocyte distribution width (RDW) was significantly lower in control group than lead-exposed group (p = 0.031). Serum ALP levels were significantly higher in lead-exposed group than control group (197 ± 51 vs. 133 ± 65) (p = 0.000). According to Spearman correlation analysis, there was a significantly negative correlation between blood lead levels and MCHC (r = -0.373, p ≤ 0.001). Also, serum ALP levels were positively correlated with blood lead levels (r = 0.436, p ≤ 0.001). The correlation between blood lead levels and RDW was statistically weak (r = 0.225, p = 0.030). Conclusions: Serum prolactin level is not a diagnostic marker for determining the effect of lead-exposure. | |
dc.identifier.doi | 10.5414/TEX01367 | |
dc.identifier.endpage | 85 | |
dc.identifier.issn | 0946-2104 | |
dc.identifier.scopus | 2-s2.0-84925294787 | |
dc.identifier.startpage | 81 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12597/15329 | |
dc.identifier.volume | 32 | |
dc.identifier.wos | WOS:000352123900006 | |
dc.relation.ispartof | Trace Elements and Electrolytes | |
dc.relation.ispartof | TRACE ELEMENTS AND ELECTROLYTES | |
dc.rights | false | |
dc.subject | Biomarker | Health | Hormone | Industry | Toxicity | |
dc.title | Lack of association between serum prolactin and lead exposure among battery workers | |
dc.title | Lack of association between serum prolactin and lead exposure among battery workers | |
dc.type | Article | |
dspace.entity.type | Publication | |
oaire.citation.issue | 2 | |
oaire.citation.volume | 32 | |
relation.isScopusOfPublication | 91b73238-fa60-4169-84bb-4f26c0861709 | |
relation.isScopusOfPublication.latestForDiscovery | 91b73238-fa60-4169-84bb-4f26c0861709 | |
relation.isWosOfPublication | 37945cf4-88f4-49c3-a0d9-511ca433d02b | |
relation.isWosOfPublication.latestForDiscovery | 37945cf4-88f4-49c3-a0d9-511ca433d02b |