ASSOCIATION BETWEEN MDR 1 (ABCB1) GENEC3435T, C1236T, G2677T/A, A2956GPOLYMORPHISMS AND THE RISK OF BREAST CANCERAMONG TURKISH WOMEN

Abstract

Objective The most common malignancy in women is breastcancer worldwide. Previous studies performed in dif ferent populations have suggested an associationbetween Multi-Drug Resistance (MDR1) gene pol ymorphisms and breast cancer risk in women. Thepurpose of the current study is to examine relationshipbetween MDR1 polymorphisms (C3435T, G2677T/A,C1236T, A2956G) and the risk of breast cancer in Tur kish women. Material and Methods In this study 35 breast cancer cases and 20 healt hy controls were enrolled. Identification of MDR1genotypes was performed with the polymerase cha in reaction/restriction fragment length polymorphism(PCR-RFLP) technique. Results We observed significant difference in distribution ofC3435T genotypes between the cases and the cont rols (cases, CC 37.1%, CT 28.6%, and TT 34.3%;controls, CC 25%, CT 65%, and TT 10%, p: 0.023).On the other hand, no significant differences in geno type and allele frequencies of C1236T and G2677T/Apolymorphisms were observed between groups. Wealso found that all subjects carry AA genotype forA2956G polymorphism. Conclusion Although our study group is small, the results suggestthat the MDR1 C3435T polymorphism may increasethe breast cancer risk in Turkish women.