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The role of ion channels on the physiology of the neurovascular unit and the regulation of cerebral blood flow

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dc.contributor.authorMontiel-herrera, Marcelıno
dc.contributor.authorGarcía-villa, Denisse
dc.contributor.authorLópez-cervantes, Guillermo
dc.contributor.authorReyes-haro, Daniel
dc.contributor.authorDomínguez-avila, J. Abraham
dc.contributor.authorGonzález-aguilar, Gustavo A.
dc.date.accessioned2026-01-04T16:30:21Z
dc.date.issued2022-02-11
dc.description.abstractThe neurovascular unit, composed of neurons, brain endothelial cells, pericytes, microglia, and astrocytes, regulates cerebral blood flow. The physical and chemical signals govern the physiology of the neurovascular unit within the network composed of its cellular components. Astrocytes have an essential role in this network since they have a privileged anatomical relationship with the rest of the cells. They are capable of sensing signals released by their neighboring cells, releasing chemical transmitters, and controlling the extracellular K+ concentration. Moreover, astrocytes play a crucial role in providing oxygen and nutrients to neurons during high neuronal firing activity. This manuscript will briefly discuss the recent evidence of astrocytes' contribution and their plethora of ion channels to the leading cellular mechanisms involved in the physiology of the neurovascular unit.
dc.description.urihttps://doi.org/10.37212/jcnos.1054986
dc.description.urihttps://dergipark.org.tr/en/download/article-file/2181067
dc.description.urihttps://dergipark.org.tr/tr/pub/jcnos/issue/68509/1054986
dc.identifier.doi10.37212/jcnos.1054986
dc.identifier.eissn2149-7222
dc.identifier.endpage1013
dc.identifier.openairedoi_dedup___::62176163d3510c3cb16a0f1948b3e3d5
dc.identifier.orcid0000-0002-8239-2356
dc.identifier.orcid0000-0001-6220-1623
dc.identifier.scopus2-s2.0-85130751780
dc.identifier.startpage1004
dc.identifier.urihttps://hdl.handle.net/20.500.12597/39500
dc.identifier.volume13
dc.publisherJournal of Cellular Neuroscience and Oxidative Stress
dc.relation.ispartofJournal of Cellular Neuroscience and Oxidative Stress
dc.rightsOPEN
dc.subjectNeurosciences
dc.subjection channels
dc.subjectastrocyte end-feet
dc.subjectneurovascular
dc.subjectendothelial cell
dc.subjectvascular smooth muscle cell
dc.subjectcapillaries.
dc.subjectSinirbilim
dc.titleThe role of ion channels on the physiology of the neurovascular unit and the regulation of cerebral blood flow
dc.typeArticle
dspace.entity.typePublication
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