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Synthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4‐Thiadiazole Moiety and Their Antimicrobial Activities

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dc.contributor.authorGür, Mahmut
dc.contributor.authorŞener, Nesrin
dc.contributor.authorKaştaş, Çiğdem A.
dc.contributor.authorÖzkan, Osman Emre
dc.contributor.authorMuğlu, Halit
dc.contributor.authorElmaswari, Magboule A. M.
dc.date.accessioned2026-01-03T10:10:03Z
dc.date.issued2017-09-14
dc.description.abstractThrough a cyclization reaction of 2‐phenylbutyric acid with N‐phenylthiosemicarbazide and POCl3, novel 1,3,4‐thiadiazole derivatives were synthesized. Their structures were confirmed using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis. The antibacterial activities of the obtained 1,3,4‐thiadiazole derivatives were tested against Gram‐negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli) and Gram‐positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans) using a disk diffusion method. Moreover, an antifungal activity experiment was performed against Candida albicans using the disk diffusion method. It was observed that the synthesized 1,3,4‐thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, E. coli, and C. albicans. Based on these results, the 1,3,4‐thiadiazole derivatives can be considered as a source of bioactive agents for pharmacological and medicinal applications.
dc.description.urihttps://doi.org/10.1002/jhet.2984
dc.description.urihttps://dx.doi.org/10.1002/jhet.2984
dc.description.urihttps://hdl.handle.net/20.500.12712/12140
dc.identifier.doi10.1002/jhet.2984
dc.identifier.eissn1943-5193
dc.identifier.endpage3590
dc.identifier.issn0022-152X
dc.identifier.openairedoi_dedup___::7ed47b4a01ab8387b5dae35e8754d234
dc.identifier.orcid0000-0001-9942-6324
dc.identifier.orcid0000-0001-5370-6048
dc.identifier.orcid0000-0003-0235-7460
dc.identifier.orcid0000-0003-4011-8815
dc.identifier.scopus2-s2.0-85034059840
dc.identifier.startpage3578
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36529
dc.identifier.volume54
dc.identifier.wos000422654000071
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.rightsCLOSED
dc.titleSynthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4‐Thiadiazole Moiety and Their Antimicrobial Activities
dc.typeArticle
dspace.entity.typePublication
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The antibacterial activities of the obtained 1,3,4‐thiadiazole derivatives were tested against Gram‐negative bacteria (<jats:italic>Salmonella enteritidis</jats:italic>, <jats:italic>Salmonella typhimurium</jats:italic>, <jats:styled-content style=\"fixed-case\"><jats:italic>Enterobacter aerogenes</jats:italic></jats:styled-content>, <jats:italic>Salmonella infantis</jats:italic>, <jats:italic>Salmonella kentucky</jats:italic>, and <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli</jats:italic></jats:styled-content>) and Gram‐positive bacteria (<jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus</jats:italic></jats:styled-content>, <jats:italic>Bacillus subtilis</jats:italic>, and <jats:italic>Enterococcus durans</jats:italic>) using a disk diffusion method. 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