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Synthesis, characterization, and antioxidant activity of some new N4-arylsubstituted-5-methoxyisatin-β-thiosemicarbazone derivatives

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dc.contributor.authorMuğlu, Halit
dc.date.accessioned2026-01-04T13:50:50Z
dc.date.issued2020-01-08
dc.description.abstractFirstly, thiosemicarbazides were prepared by the reaction of hydrazine monohydrate with isothiocyanates in cold dry ethanol at 0 °C for 1 h. After that, new isatin-β-thiosemicarbazones were synthesized by treatment of 5-methoxyisatin with thiosemicarbazides in aqueous ethanol containing one drop of hydrochloric acid at reflux for 3 h. The chemical structures of products were confirmed by means of IR, 1H NMR, and 13C NMR data and by elemental analysis. All the synthesized compounds were evaluated for their antioxidant activity by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging method. The synthesized molecules showed lower antioxidant activity than the standard Trolox (8.757 μM). IC50 values of the newly synthesized isatin-β-thiosemicarbazone derivatives ranged from 12.455 to 73.471 μM.
dc.description.urihttps://doi.org/10.1007/s11164-020-04079-x
dc.description.urihttps://dx.doi.org/10.1007/s11164-020-04079-x
dc.identifier.doi10.1007/s11164-020-04079-x
dc.identifier.eissn1568-5675
dc.identifier.endpage2098
dc.identifier.issn0922-6168
dc.identifier.openairedoi_dedup___::ca818dcdc1378a8ddd7d155cd22ea280
dc.identifier.orcid0000-0001-8306-2378
dc.identifier.scopus2-s2.0-85077577510
dc.identifier.startpage2083
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37770
dc.identifier.volume46
dc.identifier.wos000519964600006
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofResearch on Chemical Intermediates
dc.rightsCLOSED
dc.subject.sdg3. Good health
dc.titleSynthesis, characterization, and antioxidant activity of some new N4-arylsubstituted-5-methoxyisatin-β-thiosemicarbazone derivatives
dc.typeArticle
dspace.entity.typePublication
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