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The Role of Activated Cytotoxic T Cells in Etiopathogenesis of Periodontal Disease: Does It Harm or Does It Heal?

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dc.contributor.authorCifcibasi, Emine
dc.contributor.authorCiblak, Meral
dc.contributor.authorKiran, Bayram
dc.contributor.authorBadur, Selim
dc.contributor.authorFiratli, Erhan
dc.contributor.authorIssever, Halim
dc.contributor.authorCintan, Serdar
dc.date.accessioned2026-01-02T23:21:49Z
dc.date.issued2015-03-19
dc.description.abstractAbstractThe objective of this study was to determine the phenotypic profile of blood mononuclear cells, specifically CD8+/CD28+ cells, in patients with generalized aggressive periodontitis (GAgP) and chronic periodontitis (CP) in peripheral blood and in blood obtained from periodontal defect site which might contribute to tissue damage. 13 GAgP, 11 chronic periodontitis (CP) and 5 healthy controls (H) were included in the study. Plaque index (PI), bleeding on probing (BoP), periodontal probing depth (PPD) and clinical attachment level (CAL) were recorded. Blood from the base of periodontal defect site and peripheral blood from the antecubital vein were obtained. Relative counts of CD45+, CD3+, CD4+, CD8+/CD28+, CD8+/CD28−, CD19+, CD16+/CD56+/CD3, CD3+/CD16+/CD56+ receptors were determined with two color flow cytometry using monoclonal antibodies. BoP, PPD and CAL were significantly higher in both periodontitis groups than healthy controls (p <0.05). Activated cytotoxic T cells, CD8+/CD28+ cells, were significantly elevated in GAgP and CP groups compared to HC both in blood obtained from defect site and blood obtained from systemic circulation (p <0.05). GAgP and CP patients have an increased levels of activated cytotoxic T cells as a result of inflammation which may cause severe tissue damage that lead to severe and rapid loss of periodontal tissues.
dc.description.urihttps://doi.org/10.1038/srep09262
dc.description.urihttps://www.nature.com/articles/srep09262.pdf
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/25788457
dc.description.urihttp://dx.doi.org/10.1038/srep09262
dc.description.urihttps://dx.doi.org/10.1038/srep09262
dc.identifier.doi10.1038/srep09262
dc.identifier.eissn2045-2322
dc.identifier.openairedoi_dedup___::74b44047e83ff8fc33efd9819de261d0
dc.identifier.pubmed25788457
dc.identifier.scopus2-s2.0-84925427680
dc.identifier.urihttps://hdl.handle.net/20.500.12597/35966
dc.identifier.volume5
dc.identifier.wos000351274600001
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofScientific Reports
dc.rightsOPEN
dc.subjectAdult
dc.subjectMale
dc.subjectLymphocyte Activation
dc.subjectArticle
dc.subjectImmunophenotyping
dc.subjectYoung Adult
dc.subjectPhenotype
dc.subjectT-Lymphocyte Subsets
dc.subjectCase-Control Studies
dc.subjectAntigens, Surface
dc.subjectHumans
dc.subjectFemale
dc.subjectPeriodontal Diseases
dc.subjectT-Lymphocytes, Cytotoxic
dc.subject.sdg2. Zero hunger
dc.subject.sdg3. Good health
dc.titleThe Role of Activated Cytotoxic T Cells in Etiopathogenesis of Periodontal Disease: Does It Harm or Does It Heal?
dc.typeArticle
dspace.entity.typePublication
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Plaque index (PI), bleeding on probing (BoP), periodontal probing depth (PPD) and clinical attachment level (CAL) were recorded. Blood from the base of periodontal defect site and peripheral blood from the antecubital vein were obtained. Relative counts of CD45<jats:sup>+</jats:sup>, CD3<jats:sup>+</jats:sup>, CD4<jats:sup>+</jats:sup>, CD8<jats:sup>+</jats:sup>/CD28<jats:sup>+</jats:sup>, CD8<jats:sup>+</jats:sup>/CD28<jats:sup>−</jats:sup>, CD19<jats:sup>+</jats:sup>, CD16<jats:sup>+</jats:sup>/CD56<jats:sup>+</jats:sup>/CD3, CD3<jats:sup>+</jats:sup>/CD16<jats:sup>+</jats:sup>/CD56<jats:sup>+</jats:sup> receptors were determined with two color flow cytometry using monoclonal antibodies. BoP, PPD and CAL were significantly higher in both periodontitis groups than healthy controls (p &lt;0.05). 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