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Chemical fingerprints, antioxidant, enzyme inhibitory, and cell assays of three extracts obtained from Sideritis ozturkii Aytaç & Aksoy: An endemic plant from Turkey

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dc.contributor.authorZengin, Gokhan
dc.contributor.authorUğurlu, Asli
dc.contributor.authorBaloglu, Mehmet Cengiz
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJekő, József
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorAktumsek, Abdurrahman
dc.contributor.authorPicot-Allain, Carene Marie Nancy
dc.contributor.authorFawzi Mahomoodally, M
dc.date.accessioned2026-01-04T12:57:12Z
dc.date.issued2019-07-01
dc.description.abstractThis study was geared towards assessing the possible antioxidant, enzyme inhibitory, and cytotoxic activities of ethyl acetate, methanol, and water extracts of Sideritis ozturkii Aytaç & Aksoy. The phytochemical profiles of the studied extracts were characterised by HPLC-MS/MS. The methanol extract, rich in phenolics (78.04 mg gallic acid equivalent/g), exhibited the strongest antioxidant activities. However, the ethyl acetate extract was the most active extract in the enzyme inhibitory assays. The water extract of S. ozturkii (1 mg/ml, 48 h incubation) slightly inhibited (22%) growth of human breast cancer cell line (MDA-MB-231 cells). On the other hand, the ethyl acetate and methanol extracts showed strong inhibition (98% and 97%, respectively) of MDA-MB-231 cells and caused apoptotic cell death. Scientific data generated from this study further appraises the multiple biological activities of plants belonging to the Sideritis genus. In addition, preliminary evidence gathered from the current investigation advocates for further studies geared towards the preparation of therapeutic formulations from S. ozturkii.
dc.description.urihttps://doi.org/10.1016/j.jpba.2019.04.011
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/30986761
dc.description.urihttps://dx.doi.org/10.1016/j.jpba.2019.04.011
dc.identifier.doi10.1016/j.jpba.2019.04.011
dc.identifier.endpage125
dc.identifier.issn0731-7085
dc.identifier.openairedoi_dedup___::9d6d530c3d38bce31baa77cc8458fd20
dc.identifier.orcid0000-0001-6548-7823
dc.identifier.orcid0000-0003-2131-2823
dc.identifier.orcid0000-0002-7795-8482
dc.identifier.pubmed30986761
dc.identifier.scopus2-s2.0-85064181472
dc.identifier.startpage118
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37402
dc.identifier.volume171
dc.identifier.wos000468555900015
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.rightsCLOSED
dc.subjectTurkey
dc.subjectCell Survival
dc.subjectPlant Extracts
dc.subjectMethanol
dc.subjectWater
dc.subjectAcetates
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectAntioxidants
dc.subjectCell Line, Tumor
dc.subjectSolvents
dc.subjectHumans
dc.subjectSideritis
dc.subjectEnzyme Inhibitors
dc.titleChemical fingerprints, antioxidant, enzyme inhibitory, and cell assays of three extracts obtained from Sideritis ozturkii Aytaç & Aksoy: An endemic plant from Turkey
dc.typeArticle
dspace.entity.typePublication
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