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Protective effect of luteolin on acute lung injury in a rat model of sepsis

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dc.contributor.authorHalıcı, Zekai
dc.contributor.authorBayraktutan, Zafer
dc.contributor.authorÇelebi, Demet
dc.contributor.authorCalik, Ilknur
dc.contributor.authorAydin, Pelin
dc.contributor.authorCinar, Irfan
dc.contributor.authorKutlu, Zerrin
dc.contributor.authorBilici, Dilek
dc.date.accessioned2026-01-04T14:41:00Z
dc.date.issued2020-11-12
dc.description.abstractWe investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). LUT was administered 1 h after CLP surgery. Administration of LUT reduced the glutathione level and superoxide dismutase activity in rat lung tissues. We also found significant reduction of malondialdehyde following LUT treatment. LUT administration also reduced TNF-α and IL-10 mRNA expression in lung tissue. Histopathologic investigation of lung tissue supported our biochemical and molecular findings. Administration of LUT ameliorated lung injury in CLP induced septic rats owing to its antioxidant and anti-inflammatory properties.
dc.description.urihttps://doi.org/10.1080/10520295.2020.1846787
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/33176504
dc.description.urihttps://dx.doi.org/10.1080/10520295.2020.1846787
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/6646820d-d9e8-4366-a4d8-74fe2856b85c/oai
dc.identifier.doi10.1080/10520295.2020.1846787
dc.identifier.eissn1473-7760
dc.identifier.endpage585
dc.identifier.issn1052-0295
dc.identifier.openairedoi_dedup___::532c437fe57cea42083cfb690155b1dd
dc.identifier.pubmed33176504
dc.identifier.scopus2-s2.0-85096133064
dc.identifier.startpage579
dc.identifier.urihttps://hdl.handle.net/20.500.12597/38343
dc.identifier.volume96
dc.identifier.wos000588516300001
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofBiotechnic & Histochemistry
dc.rightsCLOSED
dc.subjectTumor Necrosis Factor-alpha
dc.subjectAcute Lung Injury
dc.subjectAntioxidants
dc.subjectRats
dc.subjectDisease Models, Animal
dc.subjectOxidative Stress
dc.subjectSepsis
dc.subjectAnimals
dc.subjectLuteolin
dc.subjectLung
dc.subject.sdg3. Good health
dc.titleProtective effect of luteolin on acute lung injury in a rat model of sepsis
dc.typeArticle
dspace.entity.typePublication
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