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Modulating Effects of Pycnogenol® on Oxidative Stress and DNA Damage Induced by Sepsis in Rats

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dc.contributor.authorTaner, Gokce
dc.contributor.authorBasaran, A. Ahmet
dc.contributor.authorBasaran, Nursen
dc.contributor.authorSarigol, Zehra
dc.contributor.authorBacanli, Merve
dc.contributor.authorAydin Di̇lsi̇z, Sevtap
dc.contributor.authorSahin, Tolga
dc.date.accessioned2026-01-02T23:10:46Z
dc.date.issued2014-06-11
dc.description.abstractThe aim of this study was to evaluate the protective effects of Pycnogenol® (Pyc), a complex plant extract from the bark of French maritime pine, on oxidative stress parameters (superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and total glutathione (GSH) and malondialdehyde (MDA) levels), an inflammatory cytokine (tumor necrosis factor alpha (TNF‐α) level) and also DNA damage in Wistar albino rats. Rats were treated with 100 mg/kg intraperitonally Pyc following the induction of sepsis by cecal ligation and puncture. The decreases in MDA levels and increases in GSH levels, and SOD and GPx activities were observed in the livers and kidneys of Pyc‐treated septic rats. Plasma TNF‐α level was found to be decreased in the Pyc‐treated septic rats. In the lymphocytes, kidney, and liver tissue cells of the sepsis‐induced rats, Pyc treatment significantly decreased the DNA damage and oxidative base damage using standard alkaline assay and formamidopyrimidine DNA glycosylase‐modified comet assay, respectively. In conclusion, Pyc treatment might have a role in the prevention of sepsis‐induced oxidative damage not only by decreasing DNA damage but also increasing the antioxidant status and DNA repair capacity in rats. Copyright © 2014 John Wiley & Sons, Ltd.
dc.description.urihttps://doi.org/10.1002/ptr.5184
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/24919414
dc.description.urihttps://dx.doi.org/10.1002/ptr.5184
dc.description.urihttps://avesis.gazi.edu.tr/publication/details/2aced194-ca1f-49d4-87a8-258562ac34ed/oai
dc.identifier.doi10.1002/ptr.5184
dc.identifier.eissn1099-1573
dc.identifier.endpage1700
dc.identifier.issn0951-418X
dc.identifier.openairedoi_dedup___::ee66dc8de703ff8ee851a5f75ee68a94
dc.identifier.orcid0000-0002-0290-1166
dc.identifier.orcid0000-0002-6368-2745
dc.identifier.orcid0000-0002-9132-6115
dc.identifier.pubmed24919414
dc.identifier.scopus2-s2.0-84915829390
dc.identifier.startpage1692
dc.identifier.urihttps://hdl.handle.net/20.500.12597/35839
dc.identifier.volume28
dc.identifier.wos000344324100017
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofPhytotherapy Research
dc.rightsCLOSED
dc.subjectFlavonoids
dc.subjectGlutathione Peroxidase
dc.subjectPlant Extracts
dc.subjectSuperoxide Dismutase
dc.subjectTumor Necrosis Factor-alpha
dc.subjectKidney
dc.subjectPinus
dc.subjectGlutathione
dc.subjectOxidative Stress
dc.subjectLiver
dc.subjectMalondialdehyde
dc.subjectSepsis
dc.subjectAnimals
dc.subjectRats, Wistar
dc.subjectDNA Damage
dc.subject.sdg3. Good health
dc.titleModulating Effects of Pycnogenol® on Oxidative Stress and DNA Damage Induced by Sepsis in Rats
dc.typeArticle
dspace.entity.typePublication
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