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The role of BRD7 in embryo development and glucose metabolism

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dc.contributor.authorKim, Yoo
dc.contributor.authorAndrés Salazar Hernández, Mario
dc.contributor.authorHerrema, Hilde
dc.contributor.authorDelibasi, Tuncay
dc.contributor.authorPark, Sang Won
dc.date.accessioned2026-01-02T23:43:47Z
dc.date.issued2016-07-22
dc.description.abstractAbstractBromodomain‐containing protein 7 (BRD7) is a member of bromodomain‐containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid‐gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.
dc.description.urihttps://doi.org/10.1111/jcmm.12907
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/27444544
dc.description.urihttp://dx.doi.org/10.1111/jcmm.12907
dc.description.urihttps://dx.doi.org/10.1111/jcmm.12907
dc.description.urihttp://hdl.handle.net/11655/15412
dc.description.urihttps://doi.org/https://doi.org/10.1111/jcmm.12907
dc.identifier.doi10.1111/jcmm.12907
dc.identifier.eissn1582-4934
dc.identifier.endpage1570
dc.identifier.issn1582-1838
dc.identifier.openairedoi_dedup___::79ef1397b42bec8e2af6532d902c38d3
dc.identifier.orcid0000-0002-0112-6348
dc.identifier.orcid0000-0002-5780-8209
dc.identifier.pubmed27444544
dc.identifier.scopus2-s2.0-85019254223
dc.identifier.startpage1561
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36222
dc.identifier.volume20
dc.identifier.wos000383588900015
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.rightsOPEN
dc.subjectMale
dc.subjectHeterozygote
dc.subjectChromosomal Proteins, Non-Histone
dc.subjectglucose metabolism
dc.subjectEmbryonic Development
dc.subjectResearch & Experimental Medicine
dc.subjectDiet, High-Fat
dc.subjectAdenoviridae
dc.subjectbromodomain‐containing protein 7
dc.subjectPregnancy
dc.subjectAnimals
dc.subjectHomeostasis
dc.subjectInsulin
dc.subjectRNA, Messenger
dc.subjectCrosses, Genetic
dc.subjectMice, Knockout
dc.subjectGene Expression Regulation, Developmental
dc.subjectCell Biology
dc.subjectOriginal Articles
dc.subjectGlucose
dc.subjectLiver
dc.subjectGene Knockdown Techniques
dc.subjectEmbryo Loss
dc.subjectOriginal Article
dc.subjectembryogenesis
dc.subjectFemale
dc.subjectGene Deletion
dc.subject.sdg3. Good health
dc.titleThe role of BRD7 in embryo development and glucose metabolism
dc.typeArticle
dspace.entity.typePublication
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