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Toxic element (As, Cd, Pb and Hg) biodistribution and blood biomarkers in Barbaresca sheep raised in Sicily: One Health preliminary study

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dc.contributor.authorElif Doğan
dc.contributor.authorFrancesco Fazio
dc.contributor.authorFrancesca Aragona
dc.contributor.authorVincenzo Nava
dc.contributor.authorSalvatore De Caro
dc.contributor.authorAlessandro Zumbo
dc.date.accessioned2026-01-04T20:32:06Z
dc.date.issued2024-06-24
dc.description.abstractThe health of humans, animals and the environment is interconnected. Adopting a One Health approach means intervening promptly to prevent the main diseases that affect animal health to guarantee the safety of livestock production. Exposure to toxic trace elements in sheep can lead to increased accumulation in different biological substrate, developing both acute and chronic diseases in humans and livestock. The aim of this study was to evaluate the bioaccumulation of arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in Sicilian Barbaresca sheep using the following biological substrates: milk, blood and fleece. An inductively coupled plasma mass spectrometer (ICP-MS) was used for As, Cd and Pb, and a direct mercury analyser (DMA-80) was used for Hg determination. In addition, the role of the haematological parameters as possible indicators of different biodistribution was evaluated. A statistically significant value was observed from our analysed metals in the substrates: arsenic (p < 0.001), cadmium (p < 0.01), lead (p < 0.001) and mercury (p < 0.0001). The correlation analysis showed a relationship between milk and blood for arsenic (p < 0.0001) and lead (p < 0.0001), and no correlation for the metals was observed between milk/blood and the haematological parameters analysed for the low concentration observed in the present study comforting the final consumer.
dc.description.urihttps://doi.org/10.1007/s11356-024-34060-9
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/38913265
dc.description.urihttps://hdl.handle.net/11570/3315990
dc.description.urihttps://link.springer.com/article/10.1007/s11356-024-34060-9
dc.identifier.doi10.1007/s11356-024-34060-9
dc.identifier.eissn1614-7499
dc.identifier.endpage43912
dc.identifier.openairedoi_dedup___::3a9f9d17277868e12a5ac3f8fd18510e
dc.identifier.orcid0000-0003-3198-2580
dc.identifier.orcid0000-0003-2097-0808
dc.identifier.orcid0000-0001-5966-4467
dc.identifier.orcid0000-0002-8952-6601
dc.identifier.orcid0000-0002-5174-8583
dc.identifier.pubmed38913265
dc.identifier.scopus2-s2.0-85196748230
dc.identifier.startpage43903
dc.identifier.urihttps://hdl.handle.net/20.500.12597/41868
dc.identifier.volume31
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofEnvironmental Science and Pollution Research
dc.rightsRESTRICTED
dc.subjectSheep
dc.subjectLead
dc.subjectAnimals
dc.subjectMercury
dc.subjectSicily
dc.subjectBarbaresca sheep, Blood biomarkers, Livestock, One Health, Toxic metals, Bioaccumulation
dc.subjectBiomarkers
dc.subjectCadmium
dc.subjectArsenic
dc.titleToxic element (As, Cd, Pb and Hg) biodistribution and blood biomarkers in Barbaresca sheep raised in Sicily: One Health preliminary study
dc.typeArticle
dspace.entity.typePublication
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