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Lymphocyte DNA damage in Turkish asphalt workers detected by the comet assay

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dc.contributor.authorBacaksiz, Aysegul
dc.contributor.authorKayaalti, Zeliha
dc.contributor.authorSoylemez, Esma
dc.contributor.authorTutkun, Engin
dc.contributor.authorSoylemezoglu, Tulin
dc.date.accessioned2026-01-02T20:07:43Z
dc.date.issued2012-06-01
dc.description.abstractAsphalt has a highly complex structure and it contains several organic compounds including polycyclic aromatic hydrocarbons and heterocyclic compounds. In this study, comet assay was used to detect the DNA damage in blood lymphocytes of 30 workers exposed to asphalt fumes and 30 nonexposed controls. This is the first report on Turkish asphalt workers' investigated DNA damage using the alkaline single cell gel electrophoresis (SCGE). The DNA damage was evaluated by the percentage of DNA in the comet tail (% tail DNA) for each cell. According to our results, workers exposed to asphalt fumes had higher DNA damage than the control group (p < 0.01). The present study showed that asphalt fumes caused a significant increase in DNA damage and the comet assay is a suitable method for determining DNA damage in asphalt workers.
dc.description.urihttps://doi.org/10.1080/09603123.2013.773586
dc.description.urihttps://doi.org/10.1016/j.toxlet.2012.03.702
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/23638654
dc.description.urihttps://dx.doi.org/10.1016/j.toxlet.2012.03.702
dc.description.urihttps://dx.doi.org/10.1080/09603123.2013.773586
dc.identifier.doi10.1080/09603123.2013.773586
dc.identifier.eissn1369-1619
dc.identifier.endpage17
dc.identifier.issn0960-3123
dc.identifier.openairedoi_dedup___::8a7857e791ff6e92001738d0fa13880c
dc.identifier.orcid0000-0002-7259-6216
dc.identifier.orcid0000-0002-6309-7546
dc.identifier.pubmed23638654
dc.identifier.scopus2-s2.0-84891288651
dc.identifier.startpage11
dc.identifier.urihttps://hdl.handle.net/20.500.12597/35596
dc.identifier.volume24
dc.identifier.wos000328727700002
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofInternational Journal of Environmental Health Research
dc.rightsCLOSED
dc.subjectAdult
dc.subjectMale
dc.subjectTurkey
dc.subjectConstruction Industry
dc.subjectAir Pollutants, Occupational
dc.subjectMiddle Aged
dc.subjectHydrocarbons
dc.subjectOccupational Exposure
dc.subjectHumans
dc.subjectComet Assay
dc.subjectLymphocytes
dc.subjectDNA Damage
dc.subject.sdg3. Good health
dc.titleLymphocyte DNA damage in Turkish asphalt workers detected by the comet assay
dc.typeArticle
dspace.entity.typePublication
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