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Synthesis, spectroscopic studies, and antioxidant activities of novel thio/carbohydrazones and bis-isatin derivatives from terephthalaldehyde

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dc.contributor.authorMUĞLU, Halit
dc.contributor.authorYAKAN, Hasan
dc.contributor.authorBAKIR, Temel Kan
dc.date.accessioned2026-01-04T13:56:57Z
dc.date.issued2020-02-11
dc.description.abstractNew bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bis(thio/carbohydrazone) was synthesized by the reaction of (thio)/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH.) free radical scavenging method. Compound 2 showed the best antioxidant activity.
dc.description.urihttps://doi.org/10.3906/kim-1910-13
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/33488154
dc.description.urihttp://dx.doi.org/10.3906/kim-1910-13
dc.description.urihttps://dx.doi.org/10.3906/kim-1910-13
dc.description.urihttps://hdl.handle.net/20.500.12712/10336
dc.identifier.doi10.3906/kim-1910-13
dc.identifier.eissn1303-6130
dc.identifier.endpage248
dc.identifier.openairedoi_dedup___::fb2a12ba8549bf4a5a614b4535a0ef5c
dc.identifier.orcid0000-0001-8306-2378
dc.identifier.orcid0000-0002-4428-4696
dc.identifier.orcid0000-0002-7447-1468
dc.identifier.pubmed33488154
dc.identifier.scopus2-s2.0-85081959349
dc.identifier.startpage237
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37838
dc.identifier.volume44
dc.identifier.wos000513771000018
dc.publisherThe Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
dc.relation.ispartofTURKISH JOURNAL OF CHEMISTRY
dc.rightsOPEN
dc.subjectIsatin
dc.subjectspectroscopic techniques
dc.subjectcarbohydrazone
dc.subjectSchiff bases
dc.subjectArticle
dc.subjectDPPH
dc.titleSynthesis, spectroscopic studies, and antioxidant activities of novel thio/carbohydrazones and bis-isatin derivatives from terephthalaldehyde
dc.typeArticle
dspace.entity.typePublication
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