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Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway

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dc.contributor.authorKoc, Kubra
dc.contributor.authorOzek, Nihal Simsek
dc.contributor.authorAysin, Ferhunde
dc.contributor.authorDemir, Ozlem
dc.contributor.authorYilmaz, Asli
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorGeyikoglu, Fatime
dc.contributor.authorErol, Huseyin Serkan
dc.date.accessioned2026-01-04T18:20:15Z
dc.date.issued2023-01-09
dc.description.abstractThis study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis factor-alpha (TNF-α) expression was described by RT-qPCR. Caspase-3 immunostaining was performed to evaluate apoptosis. Compared with the model group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO levels, and TNF-α expression in the ARDS+ Hispidulin group. Moreover, reduced caspase-3 immunoreactivity and activity of ACE were detected in the Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act through inhibition of the ACE activity and then regulation of inflammatory cytokine level and alteration of apoptosis.
dc.description.urihttps://doi.org/10.1080/09603123.2023.2166023
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/36624973
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/03fc0585-a03b-46a7-acbd-18528968625c/oai
dc.identifier.doi10.1080/09603123.2023.2166023
dc.identifier.eissn1369-1619
dc.identifier.endpage766
dc.identifier.issn0960-3123
dc.identifier.openairedoi_dedup___::593e12274a51a46ffeebe4e07d5a1d2f
dc.identifier.orcid0000-0001-6208-165x
dc.identifier.orcid0000-0002-7326-5670
dc.identifier.orcid0000-0003-1971-8031
dc.identifier.orcid0000-0001-9852-8839
dc.identifier.orcid0000-0001-7874-5641
dc.identifier.orcid0000-0003-2687-9167
dc.identifier.orcid0000-0003-2488-1757
dc.identifier.orcid0000-0002-9121-536x
dc.identifier.pubmed36624973
dc.identifier.scopus2-s2.0-85146245117
dc.identifier.startpage755
dc.identifier.urihttps://hdl.handle.net/20.500.12597/40464
dc.identifier.volume34
dc.identifier.wos000909864500001
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofInternational Journal of Environmental Health Research
dc.rightsOPEN
dc.subjectRespiratory Distress Syndrome
dc.subjectCaspase 3
dc.subjectTumor Necrosis Factor-alpha
dc.subjectInterleukin-8
dc.subjectFlavones
dc.subjectRats
dc.subjectAnimals
dc.subjectMitogen-Activated Protein Kinases
dc.subjectLung
dc.subjectOleic Acid
dc.subject.sdg3. Good health
dc.titleHispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway
dc.typeArticle
dspace.entity.typePublication
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