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The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus

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dc.contributor.authorAtila, Nihal Efe
dc.contributor.authorAtila, Alptug
dc.contributor.authorKaya, Zülküf
dc.contributor.authorBulut, Yunus E.
dc.contributor.authorOner, Fatih
dc.contributor.authorTopal, Kübra
dc.contributor.authorBayraktutan, Zafer
dc.contributor.authorBakan, Ebubekir
dc.date.accessioned2026-01-06T06:07:32Z
dc.date.issued2020-10-09
dc.description.abstractElevated levels of heavy metals like cadmium (Cd) and manganese (Mn) are known to lead to oxidative damage-related oto-toxicity and decreased levels of chromium (Cr) and selenium (Se) are known to lead to oto-toxicity due to reduced anti-oxidant activity. The aim of the present study was to evaluate serum levels of Cd, Mn, Cr, and Se and their relationship with tinnitus. A total of 48 patients with tinnitus (Group 1) and 40 healthy controls (Group 2) were included in the study. All participants were applied audiology tests. Severity of tinnitus was measured with Tinnitus Severity Index Questionnaire (TSIQ) in group 1. Serum Mn, Cd, Cr, and Se measurements were done by using The Agilent ICP-MS system consisted of a 7700 coupled plasma mass spectrometry (ICP-MS). Serum Cd, Mn, and Cr levels were higher in group 1 and Se level was lower in group 1 than that of group 2. We may conclude that Cd, Mn, Cr, and Se levels could play an important role in etio-pathogenesis of tinnitus, and thereby supplementation or reduction of these elements could be considered as novel therapeutic goals.
dc.description.urihttps://doi.org/10.1007/s12011-020-02420-4
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/33037493
dc.description.urihttps://dx.doi.org/10.1007/s12011-020-02420-4
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/40b31391-721c-4db5-b60b-02e7ebe83a64/oai
dc.identifier.doi10.1007/s12011-020-02420-4
dc.identifier.eissn1559-0720
dc.identifier.endpage2850
dc.identifier.issn0163-4984
dc.identifier.openairedoi_dedup___::f3ebd201294fd9e025b1a6ca4c005753
dc.identifier.orcid0000-0002-3239-4142
dc.identifier.orcid0000-0003-1501-2525
dc.identifier.orcid0000-0001-6195-3110
dc.identifier.pubmed33037493
dc.identifier.scopus2-s2.0-85092395086
dc.identifier.startpage2844
dc.identifier.urihttps://hdl.handle.net/20.500.12597/43916
dc.identifier.volume199
dc.identifier.wos000578436200004
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofBiological Trace Element Research
dc.rightsCLOSED
dc.subjectChromium
dc.subjectManganese
dc.subjectSelenium
dc.subjectTinnitus
dc.subjectHumans
dc.subjectCadmium
dc.subjectTrace Elements
dc.subject.sdg3. Good health
dc.titleThe Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus
dc.typeArticle
dspace.entity.typePublication
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