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Trimetazidine has protective effects on spermatogenesis in a streptozotocin-induced diabetic rat model

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dc.contributor.authorOzcan, M. F.
dc.contributor.authorHekimoglu, Emine Rümeysa
dc.contributor.authorEner, K.
dc.contributor.authorNamuslu, M.
dc.contributor.authorAltintas, R.
dc.contributor.authorCelik, H. T.
dc.contributor.authorAkbulut, Z.
dc.contributor.authorAltinova, S.
dc.date.accessioned2026-01-03T09:59:58Z
dc.date.issued2017-03-06
dc.description.abstractThe aim of this study was to investigate the protective effects of trimetazidine (TMZ), as an antioxidant agent, on streptozotocin (STZ)-induced diabetic rats. A total of 50 male Sprague Dawley rats were randomly classified into five groups as follows: Group 1 (control), Group 2 (STZ-induced diabetic rats), Group 3 (STZ-induced diabetic rats treated orally with 1 cc/day isotonic saline), Group 4 (diabetic rats treated orally with 10 mg/kg/day TMZ) and Group 5 (diabetic rats treated orally with 20 mg/kg/day TMZ). After 8 weeks, orchiectomy was carried out. Histopathological and electron microscopic examinations were performed in all groups. In groups 1 and 5, the structural and ultra-structural findings of the testicular tissue and spermatogenesis were found normal. In groups 2, 3 and 4, similar results were obtained in terms of the impaired testicular architecture and degeneration of spermatogenesis. The administration of an optimal dose of TMZ protects against the harmful effects of diabetes mellitus on spermatogenesis in rats. TMZ therapy can be used to maintain normal spermatogenesis in diabetic rats.
dc.description.urihttps://doi.org/10.1111/and.12780
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/28261829
dc.description.urihttps://dx.doi.org/10.1111/and.12780
dc.description.urihttps://hdl.handle.net/20.500.12899/3605
dc.description.urihttps://hdl.handle.net/20.500.12645/11132
dc.identifier.doi10.1111/and.12780
dc.identifier.issn0303-4569
dc.identifier.openairedoi_dedup___::401f09afb74361f0096573a6f9008e00
dc.identifier.orcid0000-0002-9809-7204
dc.identifier.orcid0000-0003-3145-3005
dc.identifier.orcid0000-0001-7146-4767
dc.identifier.pubmed28261829
dc.identifier.scopus2-s2.0-85014453739
dc.identifier.startpagee12780
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36417
dc.identifier.volume49
dc.identifier.wos000414965200023
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.rightsOPEN
dc.subjectMale
dc.subjectTrimetazidine
dc.subjectProtective Agents
dc.subjectAntioxidants
dc.subjectDiabetes Mellitus, Experimental
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectTestis
dc.subjectdiabetes
dc.subjectrats
dc.subjectspermatogenesis
dc.subjectstreptozotocin
dc.subjecttrimetazidine
dc.subjectAnimals
dc.subjectSpermatogenesis
dc.subject.sdg3. Good health
dc.titleTrimetazidine has protective effects on spermatogenesis in a streptozotocin-induced diabetic rat model
dc.typeArticle
dspace.entity.typePublication
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