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The effect of CTLA-4 and CD28 gene variants and circulating protein levels in patients with gastric cancer

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dc.contributor.authorArikan, Soykan
dc.contributor.authorGümüş, Alper
dc.contributor.authorKüçükhüseyin, Özlem
dc.contributor.authorCoşkun, Cihan
dc.contributor.authorTuran, Saime
dc.contributor.authorCacina, Canan
dc.contributor.authorKelten Talu, Canan
dc.contributor.authorAkyüz, Filiz
dc.contributor.authorFarooqi, Ammad Ahmad
dc.contributor.authorKıran, Bayram
dc.contributor.authorYaylım, İlhan
dc.date.accessioned2026-01-03T10:04:02Z
dc.date.issued2017-06-01
dc.description.abstractAbstract Objective Gastric cancer is one of the most common malignancies worldwide. The risk factors for gastric cancer include environmental and genetic factors. Inflammation and the immune system are known to contribute to the development of the gastric cancer. We examined the influence of critical polymorphisms of CTLA-4 and CD28 genes and circulating protein levels on the etiology of gastric cancer. Methods Genotyping of SNPs was performed in 55 gastric cancer patients and 105 healthy individuals using the PCR-RFLP method, and circulating levels of sCTLA-4 and sCD28 were measured. Results There were no significant differences in the genotype and allele distributions of the evaluated SNPs [CTLA-4-318 C>T (rs5742909), CTLA-4+49 A>G (rs231775), CD28 C>T (rs3116496)] between gastric cancer patients and controls (p=0.36, p=0.78, and p=0.80, respectively). The circulating levels of sCTLA-4 and sCD28 were significantly different between the gastric cancer group and the control group (p<0.001 and p<0.001, respectively). Conclusion The present results suggest that the CTLA-4 and CD28 gene polymorphisms that were evaluated do not play an important role in Turkish patients with gastric cancer. However, sCTLA4 and sCD28 levels were higher in cancer patients and may be useful as an auxiliary parameter in the diagnosis and monitoring of gastric cancer.
dc.description.urihttps://doi.org/10.1515/tjb-2017-0024
dc.description.urihttps://dx.doi.org/10.1515/tjb-2017-0024
dc.identifier.doi10.1515/tjb-2017-0024
dc.identifier.eissn1303-829X
dc.identifier.endpage558
dc.identifier.issn0250-4685
dc.identifier.openairedoi_dedup___::71aca177af5925f0bec488d501593de3
dc.identifier.orcid0000-0001-6298-5026
dc.identifier.orcid0000-0003-2899-5014
dc.identifier.scopus2-s2.0-85037600785
dc.identifier.startpage551
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36460
dc.identifier.volume42
dc.identifier.wos000414635400005
dc.language.isoeng
dc.publisherWalter de Gruyter GmbH
dc.relation.ispartofTurkish Journal of Biochemistry
dc.rightsOPEN
dc.subject.sdg3. Good health
dc.titleThe effect of CTLA-4 and CD28 gene variants and circulating protein levels in patients with gastric cancer
dc.typeArticle
dspace.entity.typePublication
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Good health"},"provenance":null}],"mainTitle":"The effect of CTLA-4 and CD28 gene variants and circulating protein levels in patients with gastric cancer","subTitle":null,"descriptions":["<jats:title>Abstract</jats:title> <jats:sec id=\"j_tjb-2017-0024_s_999_w2aab3b7b3b1b6b1aab1c15b1Aa\"> <jats:title>Objective</jats:title> <jats:p>Gastric cancer is one of the most common malignancies worldwide. The risk factors for gastric cancer include environmental and genetic factors. Inflammation and the immune system are known to contribute to the development of the gastric cancer. We examined the influence of critical polymorphisms of CTLA-4 and CD28 genes and circulating protein levels on the etiology of gastric cancer.</jats:p> </jats:sec> <jats:sec id=\"j_tjb-2017-0024_s_998_w2aab3b7b3b1b6b1aab1c15b2Aa\"> <jats:title>Methods</jats:title> <jats:p>Genotyping of SNPs was performed in 55 gastric cancer patients and 105 healthy individuals using the PCR-RFLP method, and circulating levels of sCTLA-4 and sCD28 were measured.</jats:p> </jats:sec> <jats:sec id=\"j_tjb-2017-0024_s_997_w2aab3b7b3b1b6b1aab1c15b3Aa\"> <jats:title>Results</jats:title> <jats:p>There were no significant differences in the genotype and allele distributions of the evaluated SNPs [CTLA-4-318 C&gt;T (rs5742909), CTLA-4+49 A&gt;G (rs231775), CD28 C&gt;T (rs3116496)] between gastric cancer patients and controls (p=0.36, p=0.78, and p=0.80, respectively). The circulating levels of sCTLA-4 and sCD28 were significantly different between the gastric cancer group and the control group (p&lt;0.001 and p&lt;0.001, respectively).</jats:p> </jats:sec> <jats:sec id=\"j_tjb-2017-0024_s_996_w2aab3b7b3b1b6b1aab1c15b4Aa\"> <jats:title>Conclusion</jats:title> <jats:p>The present results suggest that the CTLA-4 and CD28 gene polymorphisms that were evaluated do not play an important role in Turkish patients with gastric cancer. 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