Synthesis, Spectroscopic Studies and Antioxidant Activities of New 2-Benzylidene-N-Phenylhydrazine-1-Carbothioamide Derivatives

Abstract

Nowadays, thiosemicarbazone based schiff bases, which are the focus of attention due to their differential properties, are being synthesized in many studies and new aromatic structure added compounds are of significant interest in drug design and biochemistry. In this study, new thiosemicarbazide schiff bases containing different substituted groups were synthesized. The structure of new compound derivatives was characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), fourier transform infrared spectroscopy (FTIR) and elemental analyses. In addition, radical quenching capacities of newly synthesized compounds were investigated using 1,1-diphenyl-2-picryl hydrazyl (DPPH) method. IC50 values were calculated for the compounds and it was found that the antioxidant activities of the compounds changed in the order of 2>5>1>4>3. These results indicated that the presence of methoxy substituted groups that provide electrons to the aromatic ring structures of schiff bases would have positive effects on the antioxidant activities of the compounds.