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Upregulation and the clinical significance of KCNQ1OT1 and HAGLROS lncRNAs in papillary thyroid cancer: An observational study

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dc.contributor.authorMutlu Icduygu, Fadime
dc.contributor.authorAkgun, Egemen
dc.contributor.authorOzgoz, Asuman
dc.contributor.authorHekimler Ozturk, Kuyas
dc.contributor.authorSengul, Demet
dc.contributor.authorAlp, Ebru
dc.date.accessioned2026-01-04T19:02:01Z
dc.date.issued2023-07-21
dc.description.abstractLong noncoding RNAs (lncRNAs) play an important role in regulating gene expression. Changes in their expression have been associated with many types of cancer, including thyroid cancer. This study aimed to investigate how changes in the expression of potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) and HAGLR opposite strand lncRNA (HAGLROS) lncRNAs correlate with the development and clinicopathological characteristics of papillary thyroid cancer (PTC). Reverse transcription-quantitative polymerase chain reaction was used to investigate the expression of lncRNAs in both tumor and adjacent normal thyroid tissue samples of the patients. Expressions of KCNQ1OT1 and HAGLROS were upregulated in the patients tumor samples compared to the adjacent normal thyroid samples. KCNQ1OT1 expression was linked to microcarcinoma and gender, while HAGLROS expression was linked to microcarcinoma and tumor size. When only microcarcinoma samples were evaluated, KCNQ1OT1 expression was higher in tumor tissues compared to normal tissues; however, no significant difference was observed in HAGLROS expression. Our data suggests that high expressions of KCNQ1OT1 and HAGLROS might contribute to the development of PTC and disease progression, and both lncRNAs may be potential therapeutic targets in PTC patients.
dc.description.urihttps://doi.org/10.1097/md.0000000000034379
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/37478216
dc.description.urihttp://dx.doi.org/10.1097/MD.0000000000034379
dc.identifier.doi10.1097/md.0000000000034379
dc.identifier.issn0025-7974
dc.identifier.openairedoi_dedup___::e78f3ace02a25ae3bd502f8244408923
dc.identifier.orcid0000-0002-4913-9420
dc.identifier.pubmed37478216
dc.identifier.scopus2-s2.0-85165482129
dc.identifier.startpagee34379
dc.identifier.urihttps://hdl.handle.net/20.500.12597/40923
dc.identifier.volume102
dc.identifier.wos001034383100012
dc.language.isoeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofMedicine
dc.rightsOPEN
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectClinical Relevance
dc.subjectMicroRNAs
dc.subjectThyroid Cancer, Papillary
dc.subjectHumans
dc.subjectRNA, Long Noncoding
dc.subjectThyroid Neoplasms
dc.subjectUp-Regulation
dc.subjectCell Proliferation
dc.subject.sdg3. Good health
dc.titleUpregulation and the clinical significance of KCNQ1OT1 and HAGLROS lncRNAs in papillary thyroid cancer: An observational study
dc.typeArticle
dspace.entity.typePublication
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Reverse transcription-quantitative polymerase chain reaction was used to investigate the expression of lncRNAs in both tumor and adjacent normal thyroid tissue samples of the patients. Expressions of <jats:italic toggle=\"yes\">KCNQ1OT1</jats:italic> and <jats:italic toggle=\"yes\">HAGLROS</jats:italic> were upregulated in the patients tumor samples compared to the adjacent normal thyroid samples. <jats:italic toggle=\"yes\">KCNQ1OT1</jats:italic> expression was linked to microcarcinoma and gender, while <jats:italic toggle=\"yes\">HAGLROS</jats:italic> expression was linked to microcarcinoma and tumor size. When only microcarcinoma samples were evaluated, <jats:italic toggle=\"yes\">KCNQ1OT1</jats:italic> expression was higher in tumor tissues compared to normal tissues; however, no significant difference was observed in <jats:italic toggle=\"yes\">HAGLROS</jats:italic> expression. 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