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New 1,3,4-thiadiazoles based on thiophene-2-carboxylic acid: Synthesis, characterization, and antimicrobial activities

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dc.contributor.authorMuğlu, Halit
dc.contributor.authorYakan, Hasan
dc.contributor.authorShouaib, Hanan Almabrok
dc.date.accessioned2026-01-04T13:58:27Z
dc.date.issued2020-03-01
dc.description.abstractAbstract Novel 1,3,4-thiadiazole derivatives were prepared by cyclization reaction of thiophene-2-carboxylic acid with N-arylthiosemicarbazides and POCl3. The antibacterial activities of the synthesized compounds were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli), Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans), and the fungus Candida albicans using the disk diffusion method. Selected 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, C. albicans, S. typhimurium, E. aerogenes, and S. kentucky. Therefore, 1,3,4-thiadiazole derivatives can be considered as bioactive agents for pharmacological and medicinal applications. The synthesized compounds were characterized by using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis.
dc.description.urihttps://doi.org/10.1016/j.molstruc.2019.127470
dc.description.urihttps://dx.doi.org/10.1016/j.molstruc.2019.127470
dc.description.urihttps://hdl.handle.net/20.500.12712/10138
dc.identifier.doi10.1016/j.molstruc.2019.127470
dc.identifier.issn0022-2860
dc.identifier.openairedoi_dedup___::4ed603ad356871fe7be54225300e1607
dc.identifier.orcid0000-0001-8306-2378
dc.identifier.orcid0000-0002-4428-4696
dc.identifier.scopus2-s2.0-85076534627
dc.identifier.startpage127470
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37856
dc.identifier.volume1203
dc.identifier.wos000504448700087
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofJournal of Molecular Structure
dc.rightsCLOSED
dc.subjectThiophene-2-carboxylic acid
dc.subject,3,4-Thiadiazoles
dc.subjectN-arylthiosemicarbazides
dc.subjectSpectroscopic methods
dc.subjectAntimicrobial activity
dc.subject.sdg3. Good health
dc.titleNew 1,3,4-thiadiazoles based on thiophene-2-carboxylic acid: Synthesis, characterization, and antimicrobial activities
dc.typeArticle
dspace.entity.typePublication
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