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Evaluation of the Roflumilast Effect Supplemented with Linezolid in Pleural Empyema in Rats Caused by Intrapleural <i>Staphylococcus aureus</i> Inoculation

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dc.contributor.authorKerget, F.
dc.contributor.authorAraz, Ömer
dc.contributor.authorErol, Hs
dc.contributor.authorKerget, Buğra
dc.contributor.authorAkgün, Metin
dc.contributor.authorÖzmen, Sevilay
dc.contributor.authorHalıcı, Zekai
dc.date.accessioned2026-01-04T13:43:52Z
dc.date.issued2020-01-01
dc.description.abstractIn addition to tube drains, pleural empyema is treated with antibiotics and anti-inflammatory drugs. We aimed to evaluate the anti-inflammatory activity of roflumilast combined with linezolid in a rat model of pleural empyema induced by Staphylococcus aureus. A total of 40 rats were divided into 7 groups: sham (n = 4), S. aureus inoculation (n = 6), S. aureus + 10 mg/kg linezolid (n = 6), S. aureus + 5 mg/kg roflumilast (n = 6), S. aureus + 10 mg/kg linezolid + 5 mg/kg roflumilast (n = 6), S. aureus + 10 mg/kg roflumilast (n = 6), and S. aureus + 10 mg/kg linezolid + 10 mg/kg roflumilast (n = 6). Animals were administered linezolid 1 h before and 12 h after inoculation with S. aureus. Roflumilast was administered orally as a single dose 30 min before inoculation with S. aureus. Compared to linezolid treatment alone, linezolid combined with 5 mg/kg roflumilast significantly improved TNF-α, IL-1β, vasodilation/congestion, and tissue/pleural polynuclear leukocyte (PNL) infiltration (p < 0.05). Linezolid combined with 10 mg/kg roflumilast also provided a significant improvement in TNF-α, IL-1β, IL-6, endothelin-1, vasodilation/congestion, mesothelial cell damage, lung tissue PNL, and pleural PNL compared to linezolid alone (p < 0.05). Due to its anti-inflammatory effects and significant impact on recovery, roflumilast can be used in conjunction with antibiotherapy for the treatment of pleural empyema.
dc.description.urihttps://doi.org/10.7883/yoken.jjid.2019.164
dc.description.urihttps://www.jstage.jst.go.jp/article/yoken/73/1/73_JJID.2019.164/_pdf
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/31474702
dc.description.urihttps://dx.doi.org/10.7883/yoken.jjid.2019.164
dc.description.urihttps://avesis.atauni.edu.tr/publication/details/cbc9eee2-7b23-4491-88e7-69987dfa2f49/oai
dc.identifier.doi10.7883/yoken.jjid.2019.164
dc.identifier.eissn1884-2836
dc.identifier.endpage7
dc.identifier.issn1344-6304
dc.identifier.openairedoi_dedup___::6ca522b799a165c0202f8f80441ac269
dc.identifier.orcid0000-0002-5160-4854
dc.identifier.orcid0000-0003-3404-4274
dc.identifier.pubmed31474702
dc.identifier.scopus2-s2.0-85078551156
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37692
dc.identifier.volume73
dc.identifier.wos000514021800001
dc.language.isoeng
dc.publisherEditorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis
dc.relation.ispartofJapanese Journal of Infectious Diseases
dc.rightsOPEN
dc.subjectCyclopropanes
dc.subjectMale
dc.subjectStaphylococcus aureus
dc.subjectAnti-Inflammatory Agents
dc.subjectLinezolid
dc.subjectAminopyridines
dc.subjectStaphylococcal Infections
dc.subjectAnti-Bacterial Agents
dc.subjectRats
dc.subjectBenzamides
dc.subjectAnimals
dc.subjectDrug Therapy, Combination
dc.subjectRats, Wistar
dc.subjectLung
dc.subjectEmpyema, Pleural
dc.subject.sdg3. Good health
dc.titleEvaluation of the Roflumilast Effect Supplemented with Linezolid in Pleural Empyema in Rats Caused by Intrapleural &lt;i&gt;Staphylococcus aureus&lt;/i&gt; Inoculation
dc.typeArticle
dspace.entity.typePublication
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