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Changes in novel gastrointestinal and renal injury markers in the blood plasma of sheep following increasing intravenous doses of tolfenamic acid

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dc.contributor.authorYildiz, Ramazan
dc.contributor.authorCorum, Orhan
dc.contributor.authorAtik, Orkun
dc.contributor.authorDurna Corum, Duygu
dc.contributor.authorAltan, Feray
dc.contributor.authorOk, Mahmut
dc.contributor.authorUney, Kamil
dc.date.accessioned2026-01-04T12:43:26Z
dc.date.issued2019-03-01
dc.description.abstractThe administration of high doses of non-steroidal anti-inflammatory drugs (NSAID), such as tolfenamic acid (TA), has undesirable effects on different organs. Some novel biomarkers have been reported that can determine the gastrointestinal and renal injury caused by a high dose of NSAIDs or other toxic substances. This study was aimed at determining the changes in gastrointestinal (TFF2 and HYP), renal (NGAL and KIM-1) and cardiac (cTn-I, CK-MB) injury markers after the use of increasing intravenous doses of TA in sheep. TA was administered intravenously to groups of six sheep each, at the dose levels of 0 (Group 0, i.e., G0), 2 (G2), 4 (G4), 8 (G8) and 16 (G16) mg/kg. The concentrations of the studied biomarkers were measured at 3, 9, 18 and 36 h after administration of TA. The TFF2 and NGAL concentrations in G16 were found to be significantly higher (P < 0.05) than in the other groups except for G8 at different sampling times. HYP concentration in G16 was observed to be significantly (P < 0.05) lower than that in all other groups at 36 h. KIM-1 level in G16 was significantly (P < 0.05) higher than in all other groups at different sampling times. An increase in the renal markers, KIM-1 and NGAL, in G8 was observed before any change in plasma creatinine and urea. The cardiac marker cTn-I in G16 was significantly (P < 0.05) higher than in other groups at different sampling times. The results showed that the novel biomarkers (HYP, TFF2, NGAL, and KIM-1) can be used to determine gastric and renal injury in sheep.
dc.description.urihttps://doi.org/10.1556/004.2019.010
dc.description.urihttp://real.mtak.hu/95580/1/004.2019.010.pdf
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/30922094
dc.description.urihttps://dx.doi.org/10.1556/004.2019.010
dc.description.urihttps://avesis.deu.edu.tr/publication/details/710b0210-c882-44a1-836c-d187e498458c/oai
dc.description.urihttps://hdl.handle.net/11468/18585
dc.description.urihttps://doi.org/https://doi.org/10.1556/004.2019.010
dc.identifier.doi10.1556/004.2019.010
dc.identifier.eissn1588-2705
dc.identifier.endpage97
dc.identifier.issn0236-6290
dc.identifier.openairedoi_dedup___::f5a107b71e312c49f979608072a2de5a
dc.identifier.orcid0000-0003-3168-2510
dc.identifier.orcid0000-0003-2411-7492
dc.identifier.orcid0000-0002-9017-763x
dc.identifier.orcid0000-0002-8674-4873
dc.identifier.pubmed30922094
dc.identifier.scopus2-s2.0-105001939187
dc.identifier.startpage87
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37243
dc.identifier.volume67
dc.identifier.wos000462990700009
dc.publisherAkademiai Kiado Zrt.
dc.relation.ispartofActa Veterinaria Hungarica
dc.rightsOPEN
dc.subjectGastrointestinal
dc.subjectSheep
dc.subjectDose-Response Relationship, Drug
dc.subjectGastrointestinal Diseases
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectSheep Diseases
dc.subjectInjury
dc.subjectSV Veterinary science / állatorvostudomány
dc.subjectTolfenamic Acid
dc.subjectAnimals
dc.subjectAdministration, Intravenous
dc.subjectFemale
dc.subjectKidney Diseases
dc.subjectortho-Aminobenzoates
dc.subjectRenal
dc.subjectCardiac
dc.subjectBiomarkers
dc.subject.sdg2. Zero hunger
dc.titleChanges in novel gastrointestinal and renal injury markers in the blood plasma of sheep following increasing intravenous doses of tolfenamic acid
dc.typeArticle
dspace.entity.typePublication
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KIM-1 level in G16 was significantly (P &lt; 0.05) higher than in all other groups at different sampling times. An increase in the renal markers, KIM-1 and NGAL, in G8 was observed before any change in plasma creatinine and urea. The cardiac marker cTn-I in G16 was significantly (P &lt; 0.05) higher than in other groups at different sampling times. 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