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Preparation, characterization, antioxidant properties of novel Schiff bases including 5-chloroisatin-thiocarbohydrazone

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dc.contributor.authorBakır, Temel Kan
dc.contributor.authorLawag, Jamal Basir
dc.date.accessioned2026-01-04T13:57:31Z
dc.date.issued2020-02-28
dc.description.abstractThanks to its pharmaceutical properties, the Schiff group of isatin has recently had a wide range of uses. In this study, seven new Schiff bases of isatin and its derivatives were prepared from thiocarbohydrazide, isatin and substituted aldehydes in the presence of ethanol under reflux. The chemical structures of the products were confirmed by 1H NMR, 13C NMR, IR and elemental analysis. The in vitro antioxidant features of all the compounds were evaluated by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging method. The antioxidant effect was evaluated separately in two different stages: monosubstituted products synthesized with aldehyde groups and disubstituted products bound with isatin group. Accordingly, the compounds 3 and 4 showed the highest antioxidant activity and the isatin group suppressed the antioxidant effect of the disubstituted Schiff bases products.
dc.description.urihttps://doi.org/10.1007/s11164-020-04105-y
dc.description.urihttps://dx.doi.org/10.1007/s11164-020-04105-y
dc.identifier.doi10.1007/s11164-020-04105-y
dc.identifier.eissn1568-5675
dc.identifier.endpage2557
dc.identifier.issn0922-6168
dc.identifier.openairedoi_dedup___::433d983df7008f344cbb4a5dd31b09c5
dc.identifier.orcid0000-0002-7447-1468
dc.identifier.scopus2-s2.0-85083026061
dc.identifier.startpage2541
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37845
dc.identifier.volume46
dc.identifier.wos000517024400001
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofResearch on Chemical Intermediates
dc.rightsCLOSED
dc.subject.sdg3. Good health
dc.titlePreparation, characterization, antioxidant properties of novel Schiff bases including 5-chloroisatin-thiocarbohydrazone
dc.typeArticle
dspace.entity.typePublication
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