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Evaluation of subclinical retinopathy and angiopathy with OCT and OCTA in patients with systemic lupus erythematosus

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dc.contributor.authorIşık, Mehmed Uğur
dc.contributor.authorAkmaz, Berkay
dc.contributor.authorAkay, Fahrettin
dc.contributor.authorGüven, Yusuf Ziya
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorGercik, Önay
dc.contributor.authorKabadayı, Gökhan
dc.contributor.authorKurut, İdil
dc.contributor.authorAkar, Servet
dc.date.accessioned2026-01-05T22:45:34Z
dc.date.issued2020-08-26
dc.description.abstractTo evaluate the choroidal and retinal layers with optical coherence tomography (OCT) and retinal microvascular structures with optical coherence tomography angiography (OCTA) in systemic lupus erythematosus (SLE) patients.In this prospective, cross-sectional and comparative study, a total of 35 SLE patients and 35 healthy control participants were included. SLE patients who were using hydroxychloroquine (HCQ) and/or immunosuppressive agents are evaluated with OCT and OCTA. SLE patients who have no HCQ maculopathy observed in OCT were included in the patient group.Mean macular thickness and ganglion cell inner plexiform layer (GC-IPL) thicknesses were thinner in the patient group. When the parameters obtained with OCTA were evaluated, vessel (VD) and perfusion density (PD) were significantly lower in the patient group. Central foveal thickness and foveal avascular zone parameters were negatively correlated. In addition, VD and PD, and GC-IPL thicknesses were positively correlated.Application of OCTA for the evaluation of microvasculature in SLE patients may be useful in subclinical changes.
dc.description.urihttps://doi.org/10.1007/s10792-020-01561-8
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/32851556
dc.description.urihttps://dx.doi.org/10.1007/s10792-020-01561-8
dc.identifier.doi10.1007/s10792-020-01561-8
dc.identifier.eissn1573-2630
dc.identifier.endpage150
dc.identifier.issn0165-5701
dc.identifier.openairedoi_dedup___::081e2b281e7b3f9b99aafd0f7184246a
dc.identifier.orcid0000-0001-7337-5469
dc.identifier.pubmed32851556
dc.identifier.scopus2-s2.0-85089863869
dc.identifier.startpage143
dc.identifier.urihttps://hdl.handle.net/20.500.12597/43345
dc.identifier.volume41
dc.identifier.wos000563156300002
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofInternational Ophthalmology
dc.rightsCLOSED
dc.subjectCross-Sectional Studies
dc.subjectRetinal Diseases
dc.subjectHumans
dc.subjectLupus Erythematosus, Systemic
dc.subjectRetinal Vessels
dc.subjectProspective Studies
dc.subjectFluorescein Angiography
dc.subjectTomography, Optical Coherence
dc.subject.sdg3. Good health
dc.titleEvaluation of subclinical retinopathy and angiopathy with OCT and OCTA in patients with systemic lupus erythematosus
dc.typeArticle
dspace.entity.typePublication
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