Immature ganulocytes are a potential biomarker in the early diagnosis of lower extremity subacute arterial thrombosis

Abstract

Aims: Acute arterial embolism in peripheral arteries is generally diagnosed quickly. In contrast, subacute arterial thrombosis (SAT), which arises as an acute exacerbation of chronic peripheral artery disease (PAD), is often more challenging to diagnose rapidly, primarily due to the development of collateral circulation. This study aims to investigate the role of immature granulocytes (IG) in the early diagnosis of SAT in patients with chronic PAD. Methods: This retrospective study was conducted at a single center between 2019 and 2021. A total of 99 patients with chronic lower extremity PAD were included in the study. Of these, 27 patients (27.2%) who developed exacerbations in the form of SAT were assigned to the SAT group. The remaining 72 patients (72.8%) with chronic PAD were included in the control group. Blood samples from patients in both groups were collected at their first admission before receiving any treatment. Complete blood count parameters were analyzed using an automatic hematological analyzer and compared between the two groups. Results: Comparison between the control and SAT groups revealed significant differences in hemogram parameters. These parameters included white blood cell count (WBC, p