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Expression pattern of galectin-1 and galectin-3 in rat testes and epididymis during postnatal development

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dc.contributor.authorÖzbek, Mehmet
dc.contributor.authorHitit, Mustafa
dc.contributor.authorYıldırım, Nuh
dc.contributor.authorÖzgenç, Özge
dc.contributor.authorErgün, Emel
dc.contributor.authorErgün, Levent
dc.contributor.authorBeyaz, Feyzullah
dc.contributor.authorKurtdede, Nevin
dc.contributor.authorAltunay, Hikmet
dc.date.accessioned2026-01-04T12:23:50Z
dc.date.issued2018-11-01
dc.description.abstractGalectins are a family of lectins-binding beta-galactosides involved in a variety of extracellular and intracellular processes, thereby contributing to homeostasis, cell adhesion, cellular turnover, and immunity. This study aimed to determine the localization and expression of galectin-1 (Gal-1) and galectin-3 (Gal-3) in the testis and epididymis of rats at postnatal [(prepubertal (day 5), pubertal (day 20), postpubertal (day 50) and mature (day 70)] periods by using immunohistochemistry and Western blotting. Gal-1 and Gal-3 were differentially expressed in different types of cells in the testis and epididymis during postnatal development. While we detected Gal-1 expression in some spermatogenic cells and Leydig cells in the testis, not in the epididymal epithelium, Gal-3 was expressed in Sertoli cells, peritubular myoid cells, Leydig cells, smooth muscles and interstitial CD68-positive macrophages. Epithelial cells of the corpus and cauda epididymis showed an intense Gal-3 expression. Gal-1 expression was higher in the testis than in the epididymis on days 50 and 70. The expression of Gal-3 in the testis increased from the prepubertal to mature period. While the expression difference of Gal-3 was not statistically significant in the testis and epididymis until puberty, Gal-3 expression in the postpubertal and mature periods was higher in the epididymis. The expression of Gal-3 in the corpus and cauda epididymis was higher than that in the caput epididymis. In conclusion, our findings suggest that puberty has potential regulatory effect on the expression of galectins in testis and epididymis of rats. Gal-1 and 3 may play a role in the development of the reproductive system and the preservation of the immune-privileged environment in the testis, due to their pro-apoptotic and anti-apoptotic functions. The presence of intense expression of Gal-3 in the corpus and cauda epididymis may contribute to the maturation and storage of spermatozoa.
dc.description.urihttps://doi.org/10.1016/j.acthis.2018.09.006
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/30241677
dc.description.urihttps://dx.doi.org/10.1016/j.acthis.2018.09.006
dc.description.urihttps://avesis.erciyes.edu.tr/publication/details/93ad50f8-0921-4604-84f4-6294a06e7471/oai
dc.identifier.doi10.1016/j.acthis.2018.09.006
dc.identifier.endpage827
dc.identifier.issn0065-1281
dc.identifier.openairedoi_dedup___::140136b02a3a3abc3ff567fb5386dfbe
dc.identifier.orcid0000-0002-2274-5359
dc.identifier.orcid0000-0001-5636-061x
dc.identifier.orcid0000-0002-9365-4104
dc.identifier.orcid0000-0002-2983-8582
dc.identifier.pubmed30241677
dc.identifier.scopus2-s2.0-85053723728
dc.identifier.startpage814
dc.identifier.urihttps://hdl.handle.net/20.500.12597/37019
dc.identifier.volume120
dc.identifier.wos000457068700014
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofActa Histochemica
dc.rightsCLOSED
dc.subjectEpididymis
dc.subjectMale
dc.subjectGalectin 1
dc.subjectGalectin 3
dc.subjectGalectins
dc.subjectBlotting, Western
dc.subjectBlood Proteins
dc.subjectImmunohistochemistry
dc.subjectRats
dc.subjectTestis
dc.subjectAnimals
dc.subject.sdg3. Good health
dc.titleExpression pattern of galectin-1 and galectin-3 in rat testes and epididymis during postnatal development
dc.typeArticle
dspace.entity.typePublication
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