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Anticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench

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dc.contributor.authorMohamed Sharif, Khawla Omran
dc.contributor.authorTufekci, Enis Fuat
dc.contributor.authorUstaoglu, Buket
dc.contributor.authorAltunoglu, Yasemin Celik
dc.contributor.authorZengin, Gokhan
dc.contributor.authorLlorent-Martínez, E.J.
dc.contributor.authorGuney, Kerim
dc.contributor.authorBaloglu, Mehmet Cengiz
dc.date.accessioned2026-01-04T15:24:49Z
dc.date.issued2021-06-01
dc.description.abstractAbstract Echinacea purpurea (L.) Moench is an important medicinal herb; its roots, leaves and, flowers have been used by the food and pharmaceutical industries. In this study, DNA protection, antimicrobial, antioxidant-enzyme inhibition, and antiproliferative activities of water, methanol (MeOH), and ethyl acetate (EA) extracts of leaves and flowers of E. purpurea were evaluated. In addition, total phenolics and flavonoids, as well as individual compounds, were identified using colorimetric assays and HPLC-ion trap mass spectrometry, respectively. Chicoric acid and its isomer were the most abundant natural compounds, with concentrations similar to previous studies of E. purpurea. All extracts had antimicrobial activity against a broad range of bacteria, particularly Enterococcus faecalis. The antiproliferative activity of the extracts on the HeLa cells was shown. The lowest value of IC50 (73 μg/ml) came from the 24 h MeOH extract of flowers. The water extract of leaves showed strong antioxidant activity with the DPPH, ABTS, CUPRAC, and FRAP assays. EA and MeOH extracts of leaves showed a significant inhibition ability of cholinesterase and tyrosinase, respectively. The presented study suggested that E. purpurea extracts had promising therapeutic properties. Further investigation at the cellular level could be done to highlight the mechanism behind these biological activities.
dc.description.urihttps://doi.org/10.1016/j.fbio.2021.101005
dc.description.urihttps://dx.doi.org/10.1016/j.fbio.2021.101005
dc.identifier.doi10.1016/j.fbio.2021.101005
dc.identifier.issn2212-4292
dc.identifier.openairedoi_dedup___::844c81ef34ce559b4c05ace2ca55d0f1
dc.identifier.orcid0000-0001-5051-2694
dc.identifier.orcid0000-0001-6548-7823
dc.identifier.orcid0000-0002-0180-5172
dc.identifier.orcid0000-0003-2305-790x
dc.identifier.scopus2-s2.0-85103405854
dc.identifier.startpage101005
dc.identifier.urihttps://hdl.handle.net/20.500.12597/38807
dc.identifier.volume41
dc.identifier.wos000663350800009
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofFood Bioscience
dc.rightsCLOSED
dc.subject.sdg3. Good health
dc.titleAnticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench
dc.typeArticle
dspace.entity.typePublication
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