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Evaluation of DNA Damage Using 3 Comet Assay Parameters in Workers Occupationally Exposed to Lead

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dc.contributor.authorKayaaltı, Zelıha
dc.contributor.authorYavuz, İlknur
dc.contributor.authorSöylemez, Esma
dc.contributor.authorBacaksız, Ayşegül
dc.contributor.authorTutkun, Engın
dc.contributor.authorSayal, Ahmet
dc.contributor.authorSöylemezoğlu, Tülın
dc.date.accessioned2026-01-02T22:58:44Z
dc.date.issued2013-05-29
dc.description.abstractThe aim of this study was to investigate the association between DNA damage and blood lead levels in individuals occupationally exposed to lead. To evaluate this association, 61 workers exposed to lead were monitored in terms of DNA damage in blood lymphocytes. The levels of DNA damage were measured according to 3 comet assay parameters, including tail intensity (TI), tail moment (TM), and DNA tail (DNAt). A statistically significant positive correlation was found between the lead levels and TI, TM, and DNAt (p < .01). Smoking had independent effects on DNA damage. A statistically significant difference was observed between smokers and nonsmokers in regards to DNA damage parameters (p < .05). In addition, the lead and DNA damage levels in smokers were found to be significantly higher than the levels observed in nonsmoking workers (p < . 05). Our results show that exposure to lead induces genotoxic effects in peripheral lymphocytes, as measured by comet assays.
dc.description.urihttps://doi.org/10.1080/19338244.2013.787964
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/24965324
dc.description.urihttps://dx.doi.org/10.1080/19338244.2013.787964
dc.identifier.doi10.1080/19338244.2013.787964
dc.identifier.eissn2154-4700
dc.identifier.endpage125
dc.identifier.issn1933-8244
dc.identifier.openairedoi_dedup___::60a6d8e51e0a99365a12777f2f6fe0b5
dc.identifier.orcid0000-0002-6309-7546
dc.identifier.pubmed24965324
dc.identifier.scopus2-s2.0-84929748872
dc.identifier.startpage120
dc.identifier.urihttps://hdl.handle.net/20.500.12597/35703
dc.identifier.volume70
dc.identifier.wos000354875400002
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofArchives of Environmental &amp; Occupational Health
dc.subjectAdult
dc.subjectMale
dc.subjectTurkey
dc.subjectSpectrophotometry, Atomic
dc.subjectMiddle Aged
dc.subjectYoung Adult
dc.subjectLead
dc.subjectOccupational Exposure
dc.subjectMetallurgy
dc.subjectHumans
dc.subjectComet Assay
dc.subjectLymphocytes
dc.subjectDNA Damage
dc.titleEvaluation of DNA Damage Using 3 Comet Assay Parameters in Workers Occupationally Exposed to Lead
dc.typeArticle
dspace.entity.typePublication
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