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The protective effect of vitamin D against carbon tetrachloride damage to the rat liver

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dc.contributor.authorOzerkan, D.
dc.contributor.authorGuney, Şevin
dc.contributor.authorOzturk, G.
dc.contributor.authorOzsoy, N.
dc.contributor.authorAkbulut, Kazime Gonca
dc.date.accessioned2026-01-03T10:09:57Z
dc.date.issued2017-09-14
dc.description.abstractWe investigated the protective effect of vitamin D against liver damage caused by carbon tetrachloride (CCl4). Twenty-four male rats were divided into four equal groups: G1, untreated controls; G2, administered CCl4; G3, administered both CCl4 and vitamin D for 10 weeks; G4, administered CCl4 for 10 weeks and vitamin D for 12 weeks. At the end of experiment, intracardiac blood samples were taken and liver samples were removed. Hepatic damage due to CCl4 was assessed using biochemistry and histopathology. Glutathione (GSH) levels decreased, while malondialdehyde (MDA) levels increased in liver tissues of G2. Alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl-transaminase (GGT) levels increased, while albumin (ALB) levels decreased. Hepatocyte degeneration, lobular disorder, sinusoid dilation, focal necrotic areas, hyperemia, and glycogen loss were observed. Hepatic fibrosis was observed around portal areas and central veins. Bridging fibrous septa were formed between portal veins. By immunohistochemistry, both matrix metalloproteinase-9 (MMP-9) and desmin reactivity were increased. All aspects of liver damage were at least partially prevented in rats treated with vitamin D. Vitamin D appears to act as an antioxidant and anti-fibrotic to protect the rat liver against damage.
dc.description.urihttps://doi.org/10.1080/10520295.2017.1361549
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/28910170
dc.description.urihttps://dx.doi.org/10.1080/10520295.2017.1361549
dc.description.urihttps://avesis.gazi.edu.tr/publication/details/268f5130-6726-448f-90e8-ebd625688f81/oai
dc.identifier.doi10.1080/10520295.2017.1361549
dc.identifier.eissn1473-7760
dc.identifier.endpage523
dc.identifier.issn1052-0295
dc.identifier.openairedoi_dedup___::c3ec075021c9c6db78225877fa23feb8
dc.identifier.orcid0000-0002-0556-3879
dc.identifier.orcid0000-0001-6968-5472
dc.identifier.orcid0000-0002-0470-3745
dc.identifier.pubmed28910170
dc.identifier.scopus2-s2.0-85029512286
dc.identifier.startpage513
dc.identifier.urihttps://hdl.handle.net/20.500.12597/36528
dc.identifier.volume92
dc.identifier.wos000424145900007
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofBiotechnic & Histochemistry
dc.rightsOPEN
dc.subjectMale
dc.subjectReverse Transcription
dc.subjectReference Standards
dc.subjectImmunohistochemistry
dc.subjectPolymerase Chain Reaction
dc.subjectRats
dc.subjectLiver
dc.subjectAnimals
dc.subjectRats, Wistar
dc.subjectVitamin D
dc.subjectCarbon Tetrachloride
dc.subject.sdg3. Good health
dc.subject.sdg10. No inequality
dc.titleThe protective effect of vitamin D against carbon tetrachloride damage to the rat liver
dc.typeArticle
dspace.entity.typePublication
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